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Homatropine Hydrobromide

Product Name
Homatropine Hydrobromide
CAS No.
51-56-9
Chemical Name
Homatropine Hydrobromide
Synonyms
DL-Hydrobromide;r,hbr,endo-(+-);Homatropine HBr;HoMatropineHBrUSP;Isopto Homatropine;Homatropinhydrobromid;endo-(+/-)-hydrobromid;(+-)-homatropinebromide;HOMATROPINE HYDROBROMIDE;HomatropineHydrobromideGr
CBNumber
CB1185212
Molecular Formula
C16H22BrNO3
Formula Weight
356.25
MOL File
51-56-9.mol
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Homatropine Hydrobromide Property

Melting point:
214-217 °C
storage temp. 
2-8°C
solubility 
Freely soluble in water, sparingly soluble in alcohol.
form 
Solid
color 
White to Off-White
Water Solubility 
soluble
Merck 
14,4730
CAS DataBase Reference
51-56-9(CAS DataBase Reference)
EPA Substance Registry System
Homatropine hydrobromide (51-56-9)
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Safety

Hazard Codes 
T
Risk Statements 
23/24/25
Safety Statements 
45-24/25-22
RIDADR 
1544
WGK Germany 
3
RTECS 
YM5602000
HazardClass 
6.1
PackingGroup 
III
HS Code 
29399900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR3182
Product name
Homatropine Hydrobromide
Purity
pharmaceutical secondary standard, certified reference material
Packaging
500MG
Price
$216
Updated
2025/07/31
Sigma-Aldrich
Product number
PHL84120
Product name
Homatropin hydrobromide
Purity
phyproof? Reference Substance
Packaging
50MG
Price
$231
Updated
2025/07/31
Sigma-Aldrich
Product number
H0800000
Product name
Homatropine hydrobromide
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
100 mg
Price
$118
Updated
2025/07/31
Sigma-Aldrich
Product number
BP185
Product name
Homatropine hydrobromide
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$226
Updated
2025/07/31
Sigma-Aldrich
Product number
1310008
Product name
Homatropine hydrobromide
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$389
Updated
2025/07/31
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Homatropine Hydrobromide Chemical Properties,Usage,Production

Description

Homatropine is an anticholinergic agent. It reduces acetylcholine-induced contractions of isolated goat detrusor muscle strips when used at a concentration of 5 μM. Homatropine (1 μM) inhibits acetylcholine- or methacholine-induced contraction of isolated rat anococcygeus muscle. It inhibits serotonin- or thrombin-induced platelet aggregation in isolated sheep platelet-rich plasma (IC50s = 4.3 and 100 μM, respectively). Topical ophthalmic administration of homatropine induces partial mydriasis in Angora goats.

Chemical Properties

white crystals or crystalline powder

Uses

Homatropine is an anticholinergic agent. Homatropine acts as an inhibitor of the muscarinic acetylcholine receptors. Homatropine is used in eye drops as a cycloplegic and as a mydriatic, to dilate the pupil.

Uses

anticholinergic (opthalmic)

brand name

Isopto Homatropine (Alcon) .

General Description

Homatropine hydrobromide,1 H,5 H-tropan-3 -ol mandelate (ester) hydrobromide(Homatrocel), occurs as white crystals or as awhite, crystalline powder that is affected by light. It is solublein water (1:6) and alcohol (1:40), less soluble in chloroform(1:420), and insoluble in ether.
Solutions are incompatible with alkaline substances,which precipitate the free base, and with the commonreagents that precipitate alkaloids. As with atropine, solutionsare sterilized best by filtration through a bacteriologicalfilter.

Clinical Use

Homatropine hydrobromide is used topically to paralyzethe ciliary structure of the eye (cycloplegia) and to effectmydriasis. It behaves very much like atropine but is weakerand less toxic. In the eye, it acts more rapidly but less persistentlythan atropine. Dilation of the pupil takes place inabout 15 to 20 minutes, and the action subsides in about24 hours. By using a miotic, such as physostigmine, it ispossible to restore the pupil to normality in a few hours.

References

[1] N. GEORGE. Inhibitory effect of anticholinergics on the contraction of isolated caprine urinary bladder detrusor muscle[J]. Autonomic and Autacoid Pharmacology, 2010, 30 3: 173-177. DOI: 10.1111/j.1474-8673.2009.00447.x
[2] DOGGRELL S A. Effect of antimuscarinic agents on the contractile responses to cholinomimetics in the rat anococcygeus muscle.[J]. British Journal of Pharmacology, 1981, 73 4: 829-835. DOI: 10.1111/j.1476-5381.1981.tb08735.x
[3] F MICHAL  F P. Inhibition of serotonin-induced platelet aggregation in relation to thrombus production.[J]. Journal of Pharmacology and Experimental Therapeutics, 1969, 166 2: 276-284.
[4] N C WHELAN  I L  F Castillo Alcala. Efficacy of tropicamide, homatropine, cyclopentolate, atropine and hyoscine as mydriatics in Angora goats.[J]. New Zealand veterinary journal, 2011, 59 6: 328-331. DOI: 10.1080/00480169.2011.609476

Homatropine Hydrobromide Preparation Products And Raw materials

Raw materials

Preparation Products

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Homatropine Hydrobromide Suppliers

Americas 1 Belgium 2 Brazil 1 Canada 2 China 120 Europe 3 France 3 Germany 8 India 28 Ireland 2 Japan 3 Russia 1 South Korea 1 Spain 1 Switzerland 3 United Kingdom 15 United States 46 USA 1 Global 241
Matrix Fine Chemicals GmbH
Tel
--
Fax
--
Email
nfo@matrix-fine-chemicals.com
Country
Switzerland
ProdList
6968
Advantage
58
Vio Chemicals AG
Tel
--
Fax
--
Email
info@viochem.com
Country
Switzerland
ProdList
20
Advantage
58
SIGMA-RBI
Tel
--
Fax
--
Country
Switzerland
ProdList
6896
Advantage
91
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View Lastest Price from Homatropine Hydrobromide manufacturers

Shanghai Biolang Biotechnology Co., Ltd.
Product
Homatropine Hydrobromide 51-56-9
Price
US $9.90-8.80/g
Min. Order
10g
Purity
99.99%HPLC.USP42——Powder、Oil、Pills、Capsules、Tablets，Customiz
Supply Ability
1000kgs
Release date
2022-02-10
Dideu Industries Group Limited
Product
Homatropine Hydrobromide 51-56-9
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-27
Career Henan Chemical Co
Product
alpha-Hydroxybenzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester hydrobromide 51-56-9
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-24

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  • DL-Hydrobromide
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  • alpha-hydroxy-benzeneaceticaci8-methyl-8-azabicyclo(3.2.1)oct-3-yleste
  • benzeneaceticacid,alpha-hydroxy-,8-methyl-8-azabicyclo[3.2.1]oct-3-ylester,
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  • Homatropine HydrobromideQ: What is Homatropine Hydrobromide Q: What is the CAS Number of Homatropine Hydrobromide Q: What is the storage condition of Homatropine Hydrobromide Q: What are the applications of Homatropine Hydrobromide
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  • 51-56-9
  • C16H21NO3HBr
  • C16H20NO3
  • C16H22NO3Br
  • Alkaloids
  • Tropane Alkaloids
  • Aromatics