QX 314 chloride

Product Name: QX 314 chloride
CAS No.: 5369-03-9
Chemical Name: QX 314 chloride
Synonyms: QX314.Cl;QX 314 CHLORIDE;N-Ethyllidocaine chloride;Lidocaine N-ethyl chloride;QX-314;QX314;N-ETHYLLIDOCAINE CHLORIDE;[2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium chloride;N-(2,6-DIMETHYLPHENYLCARBAMOYLMETHYL)TRIETHYLAMMONIUM CHLORIDE;[2-(2,6-dimethylanilino)-2-keto-ethyl]-triethyl-ammonium chloride;[2-[(2,6-dimethylphenyl)amino]-2-oxo-ethyl]-triethyl-azanium chloride;2-(2,6-Dimethylphenylamino)-N,N,N-triethyl-2-oxoethanaminium chloride
CBNumber: CB1191994
Molecular Formula: C16H27ClN2O
Formula Weight: 298.85
MOL File: 5369-03-9.mol

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QX 314 chloride Property

Melting point:: 209-211 °C
storage temp.: Room temp
solubility: insoluble in EtOH; ≥14.95 mg/mL in DMSO with gentle warming; ≥22.3 mg/mL in H2O
form: solid
color: White
Water Solubility: Soluble in water (100mM)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: L1663
Product name: Lidocaine N-ethyl chloride
Packaging: 500MG
Price: $315
Updated: 2023/06/20

Sigma-Aldrich

Product number: L1663
Product name: Lidocaine N-ethyl chloride
Packaging: 1G
Price: $579
Updated: 2023/06/20

Cayman Chemical

Product number: 18454
Product name: QX-314 (chloride)
Purity: ≥98%
Packaging: 50mg
Price: $121
Updated: 2024/03/01

Tocris

Product number: 2313
Product name: QX314chloride
Purity: ≥99%(HPLC)
Packaging: 50
Price: $139
Updated: 2021/12/16

TRC

Product number: Q950010
Product name: QX314Chloride
Packaging: 50mg
Price: $130
Updated: 2021/12/16

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QX 314 chloride Chemical Properties,Usage,Production

Uses

QX 314 Chloride has been shown to have antitussive properties in mammalian animal models.

Uses

QX 314 chloride is a membrane-impermeant lidocaine derivative that selectively blocks sodium channels on nociceptive neurons when delivered intracellularly via the TRPV1 channel, but is reportedly ineffective with extracellular application. When supplied in combination with 1 μM capsaicin , a TRPV1 receptor agonist, 5 mM QX-314 blocks 98% of sodium current in voltage-clamped nociceptive DRG neurons. QX 314 chloride elicits a long-lasting decrease in the response to painful mechanical and thermal stimuli without imparting the motor deficits (e.g., numbness, paralysis) associated with many conventional local anesthetics. At concentrations ranging from 10-70 mM, peripheral application of QX 314 chloride dose-dependently produces robust local anesthesia with slow onset in the guinea pig intradermal wheal assay, the mouse tail-flick test, and the mouse sciatic nerve blockade model.

Biological Activity

Membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na + channels.

Biochem/physiol Actions

Lidocaine N-ethyl chloride is an intracellular voltage-gated sodium channel blocker.

storage

Room temperature

QX 314 chloride Preparation Products And Raw materials

Raw materials

Preparation Products

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QX 314 chloride Suppliers

China 36 Japan 1 Switzerland 1 United Kingdom 3 United States 10 USA 1 Global 52

TargetMol Chemicals Inc.

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Aladdin Scientific

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Aladdin Scientific

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ApexBio Technology

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Cayman Chemical Company

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United States Biological

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3B Scientific Corporation

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5369-03-9, QX 314 chlorideRelated Search:

Sulfanilamide QX-314 Linocaine hydrochloride QX 314 chloride 2-[(2,6-DIMETHYLPHENYL)AMINO]-N,N,N-TRIMETHYL-2-OXOETHANAMINIUM CL

QX 314 CHLORIDE

N-(2,6-DIMETHYLPHENYLCARBAMOYLMETHYL)TRIETHYLAMMONIUM CHLORIDE

QX314.Cl

2-(2,6-Dimethylphenylamino)-N,N,N-triethyl-2-oxoethanaminium chloride

[2-(2,6-dimethylanilino)-2-keto-ethyl]-triethyl-ammonium chloride

[2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium chloride

[2-[(2,6-dimethylphenyl)amino]-2-oxo-ethyl]-triethyl-azanium chloride

Lidocaine N-ethyl chloride

N-Ethyllidocaine chloride

QX-314;QX314;N-ETHYLLIDOCAINE CHLORIDE

Inhibitor,calcium,Sodium Channel,QX314 chloride,channel,Na channels,QX314,sodium,Na+ channels,QX-314,inhibit,QX 314 chloride,QX 314

5369-03-9

5369-3-9

C16H27N2OCl

Cell Signaling and Neuroscience

Cell Biology

BioChemical

Other Sodium Channel Modulators

Monovalent Ion Channels

Ion Channels

Voltage-gated Ion Channels

Sodium Channel Modulators

Ion Channels