ChemicalBook > CAS DataBase List > L-Glutathione

L-Glutathione

Product Name
L-Glutathione
CAS No.
27025-41-8
Chemical Name
L-Glutathione
Synonyms
GSSG;L-GLUTATHIONE OXIDIZED;GLUTATHIONE DISULFIDE;Oxiglutatione;oxidizedglutathione;L-GLUTATHIONE OXIDISED;GSSC;NOV-002;Glutathiol;oxigluthione
CBNumber
CB1200803
Molecular Formula
C20H32N6O12S2
Formula Weight
612.63
MOL File
27025-41-8.mol
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L-Glutathione Property

Melting point:
178 °C (dec.)(lit.)
alpha 
-99 º (c=4, water)
Density 
1.3688 (rough estimate)
refractive index 
-105 ° (C=2, H2O)
storage temp. 
2-8°C
solubility 
H2O: soluble
form 
powder
pka
2.12, 3.59, 8.75, 9.65(at 25℃)
color 
White to off-white
biological source
synthetic
optical activity
-111.016 (H2O)
Water Solubility 
soluble
Merck 
13,4488
BRN 
1718700
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
YPZRWBKMTBYPTK-USZNOCQGSA-N
CAS DataBase Reference
27025-41-8(CAS DataBase Reference)
EPA Substance Registry System
Oxiglutatione (27025-41-8)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25-36/37/39-27-37/39
WGK Germany 
2
RTECS 
MC0556500
HS Code 
29309090
Toxicity
mouse,LD50,intravenous,> 2gm/kg (2000mg/kg),Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 6793, 1989.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
G2299
Product name
L-Glutathione oxidized
Purity
PharmaGrade, Manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production.
Packaging
100g
Price
$1586
Updated
2024/03/01
Sigma-Aldrich
Product number
G2299
Product name
L-Glutathione oxidized
Purity
PharmaGrade, Manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production.
Packaging
1kg
Price
$10456
Updated
2024/03/01
Sigma-Aldrich
Product number
3542
Product name
Glutathione, Oxidized, Free Acid - CAS 27025-41-8 - Calbiochem
Purity
Glutathione,Oxidized,FreeAcid,CAS27025-41-8,formsa"redoxbuffer"inphys
Packaging
1g
Price
$96.7
Updated
2024/03/01
Sigma-Aldrich
Product number
3542
Product name
Glutathione, Oxidized, Free Acid - CAS 27025-41-8 - Calbiochem
Purity
Glutathione,Oxidized,FreeAcid,CAS27025-41-8,formsa"redoxbuffer"inphys
Packaging
5G
Price
$265
Updated
2024/03/01
TCI Chemical
Product number
G0073
Product name
Glutathione oxidized form
Purity
>98.0%(HPLC)
Packaging
1g
Price
$64
Updated
2024/03/01
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L-Glutathione Chemical Properties,Usage,Production

Description

L-Glutathione oxidized(GSSG) is produced by the oxidation of glutathione. Detoxification of reactive oxygen species is accompanied by production of it. It can be used for the research of sickle cells and erythrocytes. The ratio of glutathione (GSH) to oxidised glutathione (GSSG) is a key indicator of cellular oxidative stress. It can be used in the clinical diagnosis and treatment of leukaemia by detecting the level of cellular GSH/GSSG in acute myeloid leukaemia (AML), which is characterised by oxidative stress leading to abnormally low levels of oxidised glutathione, with real-time, dynamic and highly sensitive characteristics[1].

Uses

L-Glutathione is used as a Acts as hydrogen acceptor in enzymatic determination of NADP and NADPH, it is used to reduced back to glutathione (GSH) via the NADPH-dependent enzyme glutathione reductase. The ratio of GSH to GSSG is often used to gauge the level of oxidative stress in cells, with higher concentrations of GSSG implying more oxidative stress, L-Glutathione formation is used to study the polymorphism in glutathione conjugation ac tivity of human erythrocytes towards ethylene dibromide.

Application

L-Glutathione (GSH) has been used in the elution buffer to elute GST (glutathione S-transferase)-fused proteins using glutathione-agarose beads. It has been used to prepare a standard curve for GSH analyses. May be used at 5-10 mM to elute glutathione S-transferase (GST) from glutathione agarose.

Definition

ChEBI: Glutathione disulfide is an organic disulfide and a glutathione derivative. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a glutathione disulfide(2-).

Biochem/physiol Actions

L-Glutathione, oxidized is frequently measure in vivo as an indicator of oxidative stress. Oxidized L-Glutathione may be converted to L-glutathione by various reducing systems.

Side effects

There have been few studies on the side effects of glutathione use, and as a supplement, no associated side effects have been reported from consuming high glutathione only from diet. However, long-term use of glutathione supplements may reduce zinc levels, and inhaling glutathione can cause breathing problems in some people with mild asthma. In addition, there are concerns that the use of glutathione supplements may cause cramps and bloating or allergic reactions, accompanied by symptoms such as rashes. If you experience any of these side effects, stop taking the supplement and contact your doctor.

Purification Methods

Purify it by recrystallisation from 50% aqueous EtOH. Its solubility in H2O is 5%. Store it at 4o. [Li et al. J Am Chem Soc 76 225 1954, Berse et al. Can J Chem 37 1733 1959, Beilstein 4 IV 3168.]

References

[1] ABBASGHULAM. Construction of Genetically Encoded Biosensors to Monitor Subcellular Compartment-Specific Glutathione Response to Chemotherapeutic Drugs in Acute Myeloid Leukemia Cells.[J]. Analytical Chemistry, 2023, 95 5: 2838-2847. DOI:10.1021/acs.analchem.2c04255.

L-Glutathione Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from L-Glutathione manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
L-Glutathione 27025-41-8
Price
US $35.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/Week
Release date
2024-05-07
Hebei Chuanghai Biotechnology Co., Ltd
Product
L-Glutathione 27025-41-8
Price
US $10.00/kg
Min. Order
1kg
Purity
99.5%
Supply Ability
100 TON
Release date
2024-10-30
Wuhan Haorong Biotechnology Co.,Ltd
Product
L-glutathione Oxidized 27025-41-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000
Release date
2024-07-03

27025-41-8, L-GlutathioneRelated Search:

REDUCED GLUTATHIONE,L-GLUTATHIONE REDUCED,L-GLUTATHIONE (REDUCED FORM) Thiamine disulfide GLUTATHIONE PEROXIDASE S-LACTOYL-GLUTATHIONE METHYLGLYOXAL-LYASE [ISOMERIZING] NAD[P]H: OXIDIZED-GLUTATHIONE OXIDOREDUCTASE TYPE II,NAD[P]H: OXIDIZED-GLUTATHIONE OXIDOREDUCTASE,NAD[P]H: OXIDIZED-GLUTATHIONE OXIDOREDUCTASE TYPE VI L-GLUTATHIONE OXIDIZED,L-GLUTATHIONE (OXIDIZED FORM),L-GLUTATHIONE OXIDISED,GSSG L-GLUTATHIONE OXIDIZED DISODIUM SALT,GSSG DISODIUM SALT,GSSG , OXIDIZED FORM DISODIUM SALT S-NITROSO-L-GLUTATHIONE RX: GLUTATHIONE R-TRANSFERASE S-(LACTOYL)GLUTATHIONE N,S-BIS-FMOC-GLUTATHIONE L-Glutathione L-CYSTEINE-GLUTATHIONE DISULFIDE,L-CYSTEINE-GLUTATHIONE DISULPHIDE GGKPDLRPCHPPCHYIPRPKPR ([15N]GLY)-GLUTATHIONE (REDUCED) S-(1-PENTYL-5-BIOTINYLAMIDO)GLUTATHIONE S-(N,N-DIETHYLCARBAMOYL)GLUTATHIONE S-LINKED GLUTATHIONE AGAROSE,GLUTATHIONE-UNIFLOW RESIN,GLUTATHIONE-SUPERFLOW RESIN

  • NOV-002
  • White lyophilizate
  • L-Glutathione oxidized Vetec(TM) reagent grade, >=98%
  • Glutathione(Oxidized Form), free acid
  • n-(n-gamma-glutamyl-cysteinyl)glycine-(2,2)-disulfide
  • N,N’-[dithiobis[1-[(carboxymethyl)carbamoyl]ethylene]]di-,L-Glutamine
  • n’-(dithiobis(1-((carboxymethyl)carbamoyl)ethylene))di-l-glutamin
  • oxidizedglutathione
  • oxigluthione
  • S,S’-Ethylenebis(glutathione)
  • L-.GLUTATHIONE (OXIDIZED) [N-(N-L-G-GLUTAMYL-L-CYSTEINYL)GLYCINE]
  • GLUTATHIONE OXIDISED extrapure
  • glutathione, oxidised
  • Glutathiol, GSSG
  • L-Glutathione oxidized, Glutathiol, GSSG
  • 3,3'-Dithiobis[N-(carboxymethyl)-N2-(γ-glutamyl)alaninamide]
  • N,N'-Bis(carboxymethyl)-Nα,Nα'-bis(γ-glutamyl)-L-cystinamide
  • Oxyglutatione
  • l-gamma-glutamyl-l-cysteinyl glycine
  • L(-)-Glutathione, oxidized, hydrate,98+%
  • L(-)-Glutathione, oxidized, hydrate,95%
  • L(-)-Glutathione, oxidized,98%
  • L-Glutathione oxidized,GSSG, Glutathiol
  • ()-Glutathione, oxidized,L-Glutathione oxidized, GSSG, Glutathiol
  • Glutathione Oxydized
  • L(-)-Glutathionehydrate
  • L(-)-Glutathione
  • L(-)-Glutathione, oxidized, 98% 500MG
  • N,N'-[Dithiobis[1-[(carboxyMethyl)carbaMoyl]ethylene]]diglutaMine
  • GLT1JP-IN (L-GLUTATHIONE RED
  • Glutathione IMpurity C (Disulfide IMpurity)
  • L-Glutathione (oxidized) L-Glutathione (oxidized)
  • glutathionedisulphide
  • glutathione-ssg
  • glutathonedisulfide
  • Glycine,L-.gamma.-glutamyl-L-cysteinyl-,2,2’-disulfide
  • glycine,l-gamma-glutamyl-l-cysteinyl-,(2,2’)-disulfide
  • l-oxidizedglutathione
  • N-(N-.gamma.-Glutamyl-cysteinyl)glycine-2,2-disulfide
  • Glutathiol
  • Oxiglutatione
  • L-GLUTATHIONE OXIDISED
  • L-GLUTATHIONE OXIDIZED
  • L-GLUTATHIONE (OXIDIZED FORM)
  • GSSC
  • GSSG
  • (GAMMA-GLU-CYS-GLY)2
  • [GAMMA-GLU-CYS-GLY] [GAMMA-GLU-CYS-GLY]
  • GAMMA-L-GLUTAMYL-L-CYSTEINYLGLYCINE OXIDIZED
  • (-)-GLUTATHIONE, OXIDIZED
  • GLUTATHIONE DISULFIDE
  • GLUTATHIONE, OXIDIZED FORM
  • CYCLIC(GAMMA-GLU-CYS-GLY)
  • CYCLIC(GAMMA-GLU-CYS-GLY)2
  • bi(glutathion-S-yl)
  • GLUTATHIONE OXIDIZED FORM FREE ACID*LYOP HILIZED POW
  • ** APPROVAL REQ **GLUTATHIONE OXIDIZED
  • GLUTATHIONE OXIDIZED FORM FREE ACID*GRAD E II