Description Uses Biological Activity Synthesis Overdosage
ChemicalBook > CAS DataBase List > Buflomedil hydrochloride

Buflomedil hydrochloride

Description Uses Biological Activity Synthesis Overdosage
Product Name
Buflomedil hydrochloride
CAS No.
35543-24-9
Chemical Name
Buflomedil hydrochloride
Synonyms
BUFLOMEDIL HCL;Buflan;ll1656;Lofton;Loftyl;Provas;rrodan;Irrodan;a-48257;bufedil
CBNumber
CB1203561
Molecular Formula
C17H26ClNO4
Formula Weight
343.85
MOL File
35543-24-9.mol
More
Less

Buflomedil hydrochloride Property

Melting point:
192-193°
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Freely soluble in water, soluble in ethanol (96 per cent), very slightly soluble in acetone.
color 
White to Off-White
InChIKey
ZDPACSAHMZADFZ-UHFFFAOYSA-N
CAS DataBase Reference
35543-24-9(CAS DataBase Reference)
More
Less

Safety

WGK Germany 
3
RTECS 
EL9885000
HS Code 
2933.99.8290
Toxicity
LD50 in mice (mg/kg): 80 ±4.6 i.v. (Lafon)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B1157400
Product name
Buflomedil hydrochloride
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
b1157400
Price
$150
Updated
2024/03/01
Sigma-Aldrich
Product number
B5899
Product name
Buflomedil hydrochloride
Purity
analytical standard
Packaging
1g
Price
$33
Updated
2022/05/15
TCI Chemical
Product number
B3647
Product name
Buflomedil Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$29
Updated
2024/03/01
TCI Chemical
Product number
B3647
Product name
Buflomedil Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$112
Updated
2024/03/01
Sigma-Aldrich
Product number
Y0001529
Product name
Buflomedil for peak identification
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0001529
Price
$223
Updated
2024/03/01
More
Less

Buflomedil hydrochloride Chemical Properties,Usage,Production

Description

Buflomedil hydrochloride is a vasoactive drug with a variety of actions. It is an alpha-adrenoceptor antagonist and a weak calcium channel blocker. It inhibits platelet aggregation and improves erythrocyte deformability. However, its mechanism of action in peripheral vascular disease is not known.
Buflomedil has generally been well tolerated by most patients in clinical trials. The most frequently reported adverse effects include flushing, headache, vertigo, gas-trointestinal discomfort, and dizziness. These rarely require drug withdrawal. In controlled trials, adverse effects have occurred in 20% of patients assigned to buflomedil and 18% of those assigned to placebo; only gastrointestinal discomfort occurred more frequently in buflomedil-treated patients (3.4 versus 2%)

Uses

Buflomedil hydrochloride is a vasoactive agent. Its mode of action involves increasing the peripheral and cerebral blood flow in ischaemic tissues of patients, who are mostly affected with vascular diseases.
Buflomedil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in peripheral and cerebral vascular diseases

Biological Activity

Buflomedil is a non-selective antagonist of α-adrenergic receptors (α-ARs) and vasoactive compound.It binds to rat α1A- and α1B-ARs (Kis = 4.06 and 6.84 µM, respectively) and human platelet α2-ARs (IC50 = 1 µM) in radioligand binding assays.Buflomedil (0.06-60 µM) inhibits contraction of isolated canine saphenous veins induced by phenylephrine, clonidine, sympathetic nerve stimulation, or norepinephrine.It inhibits ADP-, collagen-, or epinephrine-induced aggregation of isolated human platelets when used at a concentration of 100 µM.Buflomedil (10 mg/kg) reduces hippocampal neuronal cell death in a rat model of carotid clamping-induced ischemia-reperfusion injury.
https://www.caymanchem.com

Synthesis

The target compound of buflomedil hydrochloride was synthesized from methyl 4-chlorobutyrate by condensation with pyrrolidine,then by hydrolysis,acylation,Fridel-crafts alkylation and salt formation.The structure of the target compound was confirmed by IR,1H-NMR and MS.The synthetic procedure is suitable for industrial production for the advantage of avaible materials,shorter routes,convenient operation and lower cost,the overall yield is improved from the reported 70% to 75.7%.
https://www.semanticscholar.org

Overdosage

Buflomedil is generally considered to be innocuous at therapeutic dosages. Acute toxicity is due to accidental or intentional overdosage. Overdosage causes generalized seizures and cardiac conduction abnormalities, eventually leading to cardiac arrest (SEDA-21, 215).
Meyler's Side Effects of Cardiovascular Drugs

Chemical Properties

White Solid

Originator

Fonzylane,Lafon,France,1976

Uses

1-[3-(2,4,6-Trimethoxybenzoyl)propyl]pyrrolidinium chloride is used as an vasodilator (peripheral).

Manufacturing Process

Introduce 33.6 g (0.2 mol) of 1,3,5-trimethoxybenzene and 100 ml of chlorobenzene into a 500 ml three-neck flask with stirrer, hydrochloric acid bubbler and condenser. Stir to dissolve and add 27.7 g of 4- pyrrolidinobutyronitrile (from 4-chlorobutyronitrile and pyrrolidine). Cool to about 15°-20°C and bubble hydrochloric acid gas in for 4 hours. Cool to about 5°C and add 200 cm3 of water. Stir. Decant the aqueous layer, wash again with 150 cm3 of water. Combine the aqueous layers, drive off the traces of chlorobenzene by distilling 150 cm3 of water, and heat under reflux for one hour. Cool and render alkaline by means of 60 ml of sodium hydroxide solution of 36° Baume. Extract twice with 100 ml of ether. Wash the ether with 100 ml of water. Dry the ether over sodium sulfate and slowly run in 50 ml of 5N hydrogen chloride solution in ether, at the boil. Cool in ice. Filter, wash with ether and dry in a vacuum oven. 33.6 g of crude product are obtained. Recrystallize from 200 ml of isopropanol in the presence of 3 SA carbon black. Filter. Wash and dry in a vacuum oven.
26.9 g of a white, crystalline water-soluble powder are obtained. Yield: 39.2%. Instantaneous melting point: 192°-193°C.

Therapeutic Function

Vasodilator

Buflomedil hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Buflomedil hydrochloride Suppliers

Americas 1 Belgium 3 Canada 3 China 226 Europe 3 France 5 Germany 4 India 27 Ireland 1 Italy 2 Japan 1 Poland 1 South Korea 1 Sweden 1 Switzerland 1 United Kingdom 14 United States 29 Uruguay 1 Global 324
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6011
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9816
Advantage
59
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-0712-2580635 15527768850
Email
1791901229@qq.com
Country
China
ProdList
8849
Advantage
52
Shanghai Ennopharm Co., Ltd.
Tel
+86 (21) 6435-5022
Country
China
ProdList
4271
Advantage
65
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12990
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14443
Advantage
57
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12338
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7553
Advantage
61
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22519
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
18521735133 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25015
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9552
Advantage
55
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3750
Advantage
55
TargetMol Chemicals Inc.
Tel
021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7934
Advantage
58
Shanghai Huikai Chemical Technology Co., Ltd.
Tel
021-61995394 18916691159
Email
chemicalsea@163.com
Country
China
ProdList
1975
Advantage
58
Wuhan DKY Technology Co.,Ltd.
Tel
27-81302488 18007166089
Fax
027-81302088
Email
info@dkybpc.com
Country
China
ProdList
2024
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 15221909166
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41438
Advantage
60
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
17982
Advantage
56
Shouguang Jiasheng Chemical Co., Ltd.
Tel
0536-7971999 18232719690
Fax
0536-7971999
Email
sgjiasheng@hotmail.com
Country
China
ProdList
399
Advantage
58
Wuhan Dahua Pharmaceutical Co., Ltd.
Tel
027-59262863 13277907145 3091977954
Fax
027-59420980
Country
China
ProdList
4951
Advantage
58
Wuhan Dahua Weiye Pharmaceutical Chemical Co., Ltd.
Tel
027-59420981,18702770802
Fax
027-83322098
Country
China
ProdList
1975
Advantage
50
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2989
Advantage
60
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9767
Advantage
58
Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241 18871490274
Fax
027-59599241
Email
1400878000@qq.com
Country
China
ProdList
9972
Advantage
58
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9503
Advantage
50
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3868
Advantage
58
Raw material medicin reagent co.,Ltd
Tel
025-57798860
Email
sales@njromanme.com
Country
China
ProdList
4534
Advantage
58
Chengdu Dianchun Technology Co., Ltd
Tel
400-1166-196 18502815961
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14623
Advantage
60
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29797
Advantage
68
Shenzhen Simeiquan Biotechnology Co. Ltd
Tel
18126413629 0755-23311925 2355327053
Fax
0755-23311925
Email
abel@ycgmp.com
Country
China
ProdList
5115
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131981
Advantage
58
Shenzhen Sendi Biological Technology Co., Ltd.
Tel
18124570582 TEL：0755-23574479 2355327139
Fax
0755-23229476 QQ: 2355327139
Email
siliao02@yccreate.com
Country
China
ProdList
6120
Advantage
58
Hubei widely chemical technology Co., Ltd.
Tel
027-59402396 13419635609
Fax
027-83989310
Email
13419635609@163.com
Country
China
ProdList
1993
Advantage
55
Anhui kuer Bioengineering Co., Ltd
Tel
0551-65171243 13810511747
Email
kuer@kuerhuaxue.com
Country
China
ProdList
2997
Advantage
55
Wuhan Magic Biological Technology Co., Ltd.
Tel
18872289958、027-52304252、3400508168
Fax
027-52304252
Email
3400508168@qq.com
Country
China
ProdList
1910
Advantage
55
Chemleader Biomedical Co., Limited.
Tel
021-58180488
Fax
021-58180499
Email
sales@MedChemLeader.com
Country
China
ProdList
999
Advantage
58
Taian Jiaye Biotechnology Co.Ltd
Tel
13127280945
Email
285424065@qq.com
Country
China
ProdList
9980
Advantage
55
Guangzhou Jhd Chemical Reagent Co., Ltd.
Tel
020-84383047
Fax
020-84380294
Email
sales@jhd.com.cn
Country
China
ProdList
9190
Advantage
65
Shanghai Orgchem Co.,Ltd.
Tel
+86-21-5877 1921
Fax
+86-21-5877 1925
Email
info@chemofchina.com
Country
China
ProdList
9661
Advantage
55
Shanghai BaiShun Biological Technology Co., Ltd
Tel
021-37581181
Fax
021-57456066
Email
sales@chem-mall.com
Country
China
ProdList
10335
Advantage
58
Shenzhen Regent Biochemical Technology Co., Ltd.
Tel
0755-0755-85201366 18938635012
Fax
0755-85201366
Email
sales@regentsciences.com
Country
China
ProdList
9293
Advantage
58
Zhuhai JiaYi Biological Technology Co., Ltd.
Tel
18578209868 2355327026
Fax
18578209868 QQ：2355327026
Email
steroidbest@hotmail.com
Country
China
ProdList
6504
Advantage
58
Aikon International Limited
Tel
025-66028182 18112977050
Fax
(3)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
15820
Advantage
58
Wuhan FengyaoTonghui Chemical Products Co., Ltd.
Tel
027-87466105 15377573527
Email
2678564200@qq.com
Country
China
ProdList
17997
Advantage
58
Foshan DaoQi Biological Co., Ltd.
Tel
18062666947
Fax
18062666959
Email
2355880548@qq.com
Country
China
ProdList
4229
Advantage
58
Hefei Yaogu Biological Technology Co., Ltd.
Tel
0086-0551-62993905
Fax
0086-0551-62993905
Email
info@hxygmall.com
Country
China
ProdList
3374
Advantage
58
More
Less

View Lastest Price from Buflomedil hydrochloride manufacturers

Hebei Guanlang Biotechnology Co,.LTD
Product
Buflomedil Hydrochloride 35543-24-9
Price
US $8.70/Kg/Bag
Min. Order
10g
Purity
99%
Supply Ability
10000kg
Release date
2021-07-06
Shanghai Biolang Biotechnology Co., Ltd.
Product
Buflomedil hydrochloride 35543-24-9
Price
US $9.90-8.80/g
Min. Order
10g
Purity
99.99%HPLC.USP42
Supply Ability
1000kgs
Release date
2022-02-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
1-[3-(2,4,6-Trimethoxybenzoyl)propyl]pyrrolidinium chloride 35543-24-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11

35543-24-9, Buflomedil hydrochlorideRelated Search:

Duloxetine hydrochloride Difenoconazole Centella asiatica extract Bumetanide Entacapone Oxiracetam Betahistine dihydrochloride Nicotinamide Idarubicin hydrochloride Gemcitabine hydrochloride 5-Diethylamino-2-pentanone Pyrrole Buflomedil 2,4,6-Trimethoxybenzaldehyde Buflomedil hydrochloride 4-(4-AMINOBUTYL)PHENOL 4-(4-METHOXYPHENYL)BUTAN-1-AMINE P-DEMETHYLBUFLOMEDIL

  • BUFLOMEDIL HCL EP
  • BuflomedilHclC17H25No4.Hcl
  • BUFLOMEDIL HCL
  • BUFLOMEDIL HYDROCHLORIDE
  • ll1656
  • 2',4',6-Trimethoxy-4-[1-pyrrolidinyl] butyrophenone hydrochloride
  • Buflan
  • Durabuflo
  • Buflocit
  • Buflonat
  • Irrodan
  • Irrodan R
  • Lofton
  • Loftyl
  • Provas
  • 1-(4-oxo-4-(2,4,6-triMethoxyphenyl)butyl)pyrrolidin-1-iuM chloride
  • 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone,hydrochloride (1:1)
  • 4-(pyrrolidin-1-yl)-1-(2,4,6-trimethoxyphenyl)butan-1-one hydrochloride
  • Buflomedilhydrochloride(GMP)
  • rrodan
  • Bulflomedil HCL
  • Buflomedil for peak identification
  • 4-(2,3,4,5-tetrahydropyrrol-1-yl)-1-(2,4,6-trimethoxyphenyl)-1-butanone chloride
  • 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanonhydrochloride
  • 4-(1-pyrrolidyl)-1-(2,4,6-trimethoxyphenyl)-1-butanonehydrochloride
  • a-48257
  • bufedil
  • chlorhydratede(trimethoxy-2-4-6)phenyl-(pyrrolidine-3)propylacetone
  • fonzylane
  • 1-[3-(2,4,6-trimethoxybenzoyl)propyl]pyrrolidinium chloride
  • 4-(1-PYRROLIDINYL)-1-(2,4,6-TRIMETHOXYPHENYL)-1-BUTANONE HYDROCHLORIDE
  • 4-[1-PYRROLIDINYL]-[2,4,6-TRIMETHOXYPHENYL]-1-BUTANONE HYDROCHLORIDE
  • Buflomedil hydrochloride / Buflomedil HCl
  • Buflomedil hydrochloride CRS
  • Buflomedil for peak identification CRS
  • Buflomedil Hydrochloride &gt
  • 1-[3-(2,4,6-Trimethoxybenzoyl)propyl]pyrrolidinium chloride USP/EP/BP
  • bulflomedil hydrochloride
  • Buflomedil Hydrochloride, ≥ 98.0%
  • 35543-24-9
  • C18H27ClO4
  • C17H25NO4ClH
  • C17H26ClNO4
  • C17H25NO4HCl
  • BUFEDIL
  • APIs
  • API
  • Pharmaceutical intermediate