Buflomedil hydrochloride
Description Uses Biological Activity Synthesis Overdosage- Product Name
- Buflomedil hydrochloride
- CAS No.
- 35543-24-9
- Chemical Name
- Buflomedil hydrochloride
- Synonyms
- BUFLOMEDIL HCL;Buflan;ll1656;Lofton;Loftyl;Provas;rrodan;Irrodan;a-48257;bufedil
- CBNumber
- CB1203561
- Molecular Formula
- C17H26ClNO4
- Formula Weight
- 343.85
- MOL File
- 35543-24-9.mol
Buflomedil hydrochloride Property
- Melting point:
- 192-193°
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Freely soluble in water, soluble in ethanol (96 per cent), very slightly soluble in acetone.
- form
- Solid
- color
- White to Off-White
- InChIKey
- ZDPACSAHMZADFZ-UHFFFAOYSA-N
- CAS DataBase Reference
- 35543-24-9(CAS DataBase Reference)
Safety
- WGK Germany
- 3
- RTECS
- EL9885000
- HS Code
- 2933.99.8290
- Toxicity
- LD50 in mice (mg/kg): 80 ±4.6 i.v. (Lafon)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B1157400
- Product name
- Buflomedil hydrochloride
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- b1157400
- Price
- $150
- Updated
- 2024/03/01
- Product number
- B5899
- Product name
- Buflomedil hydrochloride
- Purity
- analytical standard
- Packaging
- 1g
- Price
- $33
- Updated
- 2022/05/15
- Product number
- B3647
- Product name
- Buflomedil Hydrochloride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $29
- Updated
- 2024/03/01
- Product number
- B3647
- Product name
- Buflomedil Hydrochloride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $112
- Updated
- 2024/03/01
- Product number
- Y0001529
- Product name
- Buflomedil for peak identification
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0001529
- Price
- $223
- Updated
- 2024/03/01
Buflomedil hydrochloride Chemical Properties,Usage,Production
Description
Buflomedil hydrochloride is a vasoactive drug with a variety of actions. It is an alpha-adrenoceptor antagonist and a weak calcium channel blocker. It inhibits platelet aggregation and improves erythrocyte deformability. However, its mechanism of action in peripheral vascular disease is not known.
Buflomedil has generally been well tolerated by most patients in clinical trials. The most frequently reported adverse effects include flushing, headache, vertigo, gas-trointestinal discomfort, and dizziness. These rarely require drug withdrawal. In controlled trials, adverse effects have occurred in 20% of patients assigned to buflomedil and 18% of those assigned to placebo; only gastrointestinal discomfort occurred more frequently in buflomedil-treated patients (3.4 versus 2%)
Uses
Buflomedil hydrochloride is a vasoactive agent. Its mode of action involves increasing the peripheral and cerebral blood flow in ischaemic tissues of patients, who are mostly affected with vascular diseases.
Buflomedil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in peripheral and cerebral vascular diseases
Biological Activity
Buflomedil is a non-selective antagonist of α-adrenergic receptors (α-ARs) and vasoactive compound.It binds to rat α1A- and α1B-ARs (Kis = 4.06 and 6.84 µM, respectively) and human platelet α2-ARs (IC50 = 1 µM) in radioligand binding assays.Buflomedil (0.06-60 µM) inhibits contraction of isolated canine saphenous veins induced by phenylephrine, clonidine, sympathetic nerve stimulation, or norepinephrine.It inhibits ADP-, collagen-, or epinephrine-induced aggregation of isolated human platelets when used at a concentration of 100 µM.Buflomedil (10 mg/kg) reduces hippocampal neuronal cell death in a rat model of carotid clamping-induced ischemia-reperfusion injury.
https://www.caymanchem.com
Synthesis
The target compound of buflomedil hydrochloride was synthesized from methyl 4-chlorobutyrate by condensation with pyrrolidine,then by hydrolysis,acylation,Fridel-crafts alkylation and salt formation.The structure of the target compound was confirmed by IR,1H-NMR and MS.The synthetic procedure is suitable for industrial production for the advantage of avaible materials,shorter routes,convenient operation and lower cost,the overall yield is improved from the reported 70% to 75.7%.
https://www.semanticscholar.org
Overdosage
Buflomedil is generally considered to be innocuous at therapeutic dosages. Acute toxicity is due to accidental or intentional overdosage. Overdosage causes generalized seizures and cardiac conduction abnormalities, eventually leading to cardiac arrest (SEDA-21, 215).
Meyler's Side Effects of Cardiovascular Drugs
Chemical Properties
White Solid
Originator
Fonzylane,Lafon,France,1976
Uses
1-[3-(2,4,6-Trimethoxybenzoyl)propyl]pyrrolidinium chloride is used as an vasodilator (peripheral).
Manufacturing Process
Introduce 33.6 g (0.2 mol) of 1,3,5-trimethoxybenzene and 100 ml of
chlorobenzene into a 500 ml three-neck flask with stirrer, hydrochloric acid
bubbler and condenser. Stir to dissolve and add 27.7 g of 4-
pyrrolidinobutyronitrile (from 4-chlorobutyronitrile and pyrrolidine). Cool to
about 15°-20°C and bubble hydrochloric acid gas in for 4 hours. Cool to about
5°C and add 200 cm3 of water. Stir. Decant the aqueous layer, wash again
with 150 cm3 of water. Combine the aqueous layers, drive off the traces of
chlorobenzene by distilling 150 cm3 of water, and heat under reflux for one
hour. Cool and render alkaline by means of 60 ml of sodium hydroxide
solution of 36° Baume. Extract twice with 100 ml of ether. Wash the ether
with 100 ml of water. Dry the ether over sodium sulfate and slowly run in 50
ml of 5N hydrogen chloride solution in ether, at the boil. Cool in ice. Filter,
wash with ether and dry in a vacuum oven. 33.6 g of crude product are
obtained. Recrystallize from 200 ml of isopropanol in the presence of 3 SA
carbon black. Filter. Wash and dry in a vacuum oven.
26.9 g of a white, crystalline water-soluble powder are obtained. Yield:
39.2%. Instantaneous melting point: 192°-193°C.
Therapeutic Function
Vasodilator
Buflomedil hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Buflomedil hydrochloride manufacturers
- Product
- Buflomedil Hydrochloride 35543-24-9
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- More Than 99%
- Supply Ability
- 100kg/Month
- Release date
- 2024-09-05
- Product
- Buflomedil Hydrochloride 35543-24-9
- Price
- US $8.70/kg
- Min. Order
- 10kg
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-21
- Product
- Buflomedil hydrochloride 35543-24-9
- Price
- US $9.90-8.80/g
- Min. Order
- 10g
- Purity
- 99.99%HPLC.USP42
- Supply Ability
- 1000kgs
- Release date
- 2022-02-10