Buflomedil

Product Name: Buflomedil
CAS No.: 55837-25-7
Chemical Name: Buflomedil
Synonyms: BUFLOMEDIL;Buflomedilum;AURORA KA-850;BufluomedilHcl;Buflomedil Hcl 35543-24-9 / Base;Buflomedil (base and/or unspecified salts);2',4',6'-Trimethoxy-4-(1-pyrrolidinyl)butyrophenone;4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanon;4-pyrrolidin-1-yl-1-(2,4,6-trimethoxyphenyl)butan-1-one;4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone
CBNumber: CB8675435
Molecular Formula: C17H25NO4
Formula Weight: 307.38
MOL File: 55837-25-7.mol

More

Less

Buflomedil Property

Boiling point:: 454.5±45.0 °C(Predicted)
Density: 1.090±0.06 g/cm3(Predicted)
pka: 10.15±0.20(Predicted)
LogP: 3.131 (est)
CAS DataBase Reference: 55837-25-7(CAS DataBase Reference)
NIST Chemistry Reference: Buflomedil(55837-25-7)

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: EL9885000
HS Code: 29339990

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0006341
Product name: BUFLOMEDIL
Purity: 95.00%
Packaging: 5G
Price: $878.71
Updated: 2021/12/16

More

Less

Buflomedil Chemical Properties,Usage,Production

Originator

Fonzylane,Lafon,France,1976

Uses

BAN; DCF; MI.

Definition

ChEBI: 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone is an aromatic ketone.

Manufacturing Process

Introduce 33.6 g (0.2 mol) of 1,3,5-trimethoxybenzene and 100 ml of chlorobenzene into a 500 ml three-neck flask with stirrer, hydrochloric acid bubbler and condenser. Stir to dissolve and add 27.7 g of 4- pyrrolidinobutyronitrile (from 4-chlorobutyronitrile and pyrrolidine). Cool to about 15°-20°C and bubble hydrochloric acid gas in for 4 hours. Cool to about 5°C and add 200 cm3 of water. Stir. Decant the aqueous layer, wash again with 150 cm3 of water. Combine the aqueous layers, drive off the traces of chlorobenzene by distilling 150 cm3 of water, and heat under reflux for one hour. Cool and render alkaline by means of 60 ml of sodium hydroxide solution of 36° Baume. Extract twice with 100 ml of ether. Wash the ether with 100 ml of water. Dry the ether over sodium sulfate and slowly run in 50 ml of 5N hydrogen chloride solution in ether, at the boil. Cool in ice. Filter, wash with ether and dry in a vacuum oven. 33.6 g of crude product are obtained. Recrystallize from 200 ml of isopropanol in the presence of 3 SA carbon black. Filter. Wash and dry in a vacuum oven.
26.9 g of a white, crystalline water-soluble powder are obtained. Yield: 39.2%. Instantaneous melting point: 192°-193°C.

Therapeutic Function

Vasodilator

Buflomedil Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Buflomedil Suppliers

Austria 1 China 40 Europe 4 France 2 Germany 2 India 1 Switzerland 1 United Kingdom 6 United States 15 Global 72

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2127
Advantage: 70

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7815
Advantage: 57

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9901
Advantage: 58

Eastbang Pharmaceuticals Technology Co., Ltd.

Tel: +86 (20) 28996708,29078958,28139708,29076128,28133708,28139728,28139738,28133718,021-31663278,021-31663578,021-60538387
Fax: +86 (20) 39218032
Country: China
ProdList: 454
Advantage: 58

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9533
Advantage: 58

Hangzhou J&H Chemical Co., Ltd.

Tel: +86-571-87396432 0571-87396433
Fax: 0571-87396431
Email: sales@jhechem.com
Country: China
ProdList: 10015
Advantage: 53

Guangzhou Ciming Biological Technology Co., Ltd.

Tel: 020-38082199,29065168,38082986,29878298,29866629,4000192398
Fax: +86 (20)38082986
Country: China
ProdList: 831
Advantage: 60

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9926
Advantage: 65

Chengdu Saint - Kay Biotechnology Co., Ltd.

Tel: 028-85157043 15882256948
Email: 676046971@qq.com
Country: China
ProdList: 4392
Advantage: 58

Finetech Industry Limited

Tel: +86-27-87465837 +8618971612321
Fax: 86 27 87772287
Email: info@finetechnology-ind.com
Country: China
ProdList: 9571
Advantage: 58

55837-25-7, BuflomedilRelated Search:

Anisole 3-Methoxybenzaldehyde (Trifluoromethoxy)benzene Prostaglandin E1 p-Anisaldehyde Diltiazem Diltiazem hydrochloride 4-Methoxyphenylacetic acid p-Anisidine 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil 4-Methoxyphenylacetone 4-Methoxybenzylchloride BufloMedil iMpurity (o-desMethyl) BufloMedil Related IMpurity BUFLOMEDIL IMPURITY B Buflomedil pyridoxal phosphate 1-PYRROLIDINOBUTYRONITRILE(BUFLOMEDIL INTERMEDIATE) 2-Butanone

1-Butanone, 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-

2',4',6'-Trimethoxy-4-(1-pyrrolidinyl)butyrophenone

4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanon

AURORA KA-850

BUFLOMEDIL

BufluomedilHcl

Buflomedil Hcl 35543-24-9 / Base

Buflomedil (base and/or unspecified salts)

4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone

4-pyrrolidin-1-yl-1-(2,4,6-trimethoxyphenyl)butan-1-one

Buflomedilum

55837-25-7

C17H25NO4xHCl

Analytical Standards

Analytical Chromatography Product Catalog

Alphabetic

BI - BZ

API

Adrenoceptor

Pharmaceutical

Active Pharmaceutical Ingredients