Buflomedil

Product Name: Buflomedil
CAS No.: 55837-25-7
Chemical Name: Buflomedil
Synonyms: BUFLOMEDIL;Buflomedilum;AURORA KA-850;BufluomedilHcl;Buflomedil Hcl 35543-24-9 / Base;Buflomedil (base and/or unspecified salts);2',4',6'-Trimethoxy-4-(1-pyrrolidinyl)butyrophenone;4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanon;4-pyrrolidin-1-yl-1-(2,4,6-trimethoxyphenyl)butan-1-one;4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone
CBNumber: CB8675435
Molecular Formula: C17H25NO4
Formula Weight: 307.38
MOL File: 55837-25-7.mol

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Buflomedil Property

Boiling point:: 454.5±45.0 °C(Predicted)
Density: 1.090±0.06 g/cm3(Predicted)
pka: 10.15±0.20(Predicted)
LogP: 3.131 (est)
CAS DataBase Reference: 55837-25-7(CAS DataBase Reference)
NIST Chemistry Reference: Buflomedil(55837-25-7)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: EL9885000
HS Code: 29339990

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0006341
Product name: BUFLOMEDIL
Purity: 95.00%
Packaging: 5G
Price: $878.71
Updated: 2021/12/16

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Buflomedil Chemical Properties,Usage,Production

Originator

Fonzylane,Lafon,France,1976

Uses

BAN; DCF; MI.

Definition

ChEBI: 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone is an aromatic ketone.

Manufacturing Process

Introduce 33.6 g (0.2 mol) of 1,3,5-trimethoxybenzene and 100 ml of chlorobenzene into a 500 ml three-neck flask with stirrer, hydrochloric acid bubbler and condenser. Stir to dissolve and add 27.7 g of 4- pyrrolidinobutyronitrile (from 4-chlorobutyronitrile and pyrrolidine). Cool to about 15°-20°C and bubble hydrochloric acid gas in for 4 hours. Cool to about 5°C and add 200 cm3 of water. Stir. Decant the aqueous layer, wash again with 150 cm3 of water. Combine the aqueous layers, drive off the traces of chlorobenzene by distilling 150 cm3 of water, and heat under reflux for one hour. Cool and render alkaline by means of 60 ml of sodium hydroxide solution of 36° Baume. Extract twice with 100 ml of ether. Wash the ether with 100 ml of water. Dry the ether over sodium sulfate and slowly run in 50 ml of 5N hydrogen chloride solution in ether, at the boil. Cool in ice. Filter, wash with ether and dry in a vacuum oven. 33.6 g of crude product are obtained. Recrystallize from 200 ml of isopropanol in the presence of 3 SA carbon black. Filter. Wash and dry in a vacuum oven.
26.9 g of a white, crystalline water-soluble powder are obtained. Yield: 39.2%. Instantaneous melting point: 192°-193°C.

Therapeutic Function

Vasodilator

Buflomedil Preparation Products And Raw materials

Raw materials

Preparation Products

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Buflomedil Suppliers

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55837-25-7, BuflomedilRelated Search:

Anisole 3-Methoxybenzaldehyde (Trifluoromethoxy)benzene Prostaglandin E1 p-Anisaldehyde Diltiazem Diltiazem hydrochloride 4-Methoxyphenylacetic acid p-Anisidine 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil 4-Methoxyphenylacetone 4-Methoxybenzylchloride BufloMedil iMpurity (o-desMethyl) BufloMedil Related IMpurity BUFLOMEDIL IMPURITY B Buflomedil pyridoxal phosphate 1-PYRROLIDINOBUTYRONITRILE(BUFLOMEDIL INTERMEDIATE) 2-Butanone

1-Butanone, 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-

2',4',6'-Trimethoxy-4-(1-pyrrolidinyl)butyrophenone

4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanon

AURORA KA-850

BUFLOMEDIL

BufluomedilHcl

Buflomedil Hcl 35543-24-9 / Base

Buflomedil (base and/or unspecified salts)

4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone

4-pyrrolidin-1-yl-1-(2,4,6-trimethoxyphenyl)butan-1-one

Buflomedilum

55837-25-7

C17H25NO4xHCl

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