ChemicalBook > CAS DataBase List > Buflomedil

Buflomedil

Product Name
Buflomedil
CAS No.
55837-25-7
Chemical Name
Buflomedil
Synonyms
BUFLOMEDIL;Buflomedilum;AURORA KA-850;BufluomedilHcl;Buflomedil Hcl 35543-24-9 / Base;Buflomedil (base and/or unspecified salts);2',4',6'-Trimethoxy-4-(1-pyrrolidinyl)butyrophenone;4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanon;4-pyrrolidin-1-yl-1-(2,4,6-trimethoxyphenyl)butan-1-one;4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone
CBNumber
CB8675435
Molecular Formula
C17H25NO4
Formula Weight
307.38
MOL File
55837-25-7.mol
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Buflomedil Property

Boiling point:
454.5±45.0 °C(Predicted)
Density 
1.090±0.06 g/cm3(Predicted)
pka
10.15±0.20(Predicted)
LogP
3.131 (est)
CAS DataBase Reference
55837-25-7(CAS DataBase Reference)
NIST Chemistry Reference
Buflomedil(55837-25-7)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
EL9885000
HS Code 
29339990
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0006341
Product name
BUFLOMEDIL
Purity
95.00%
Packaging
5G
Price
$878.71
Updated
2021/12/16
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Buflomedil Chemical Properties,Usage,Production

Originator

Fonzylane,Lafon,France,1976

Uses

BAN; DCF; MI.

Definition

ChEBI: 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone is an aromatic ketone.

Manufacturing Process

Introduce 33.6 g (0.2 mol) of 1,3,5-trimethoxybenzene and 100 ml of chlorobenzene into a 500 ml three-neck flask with stirrer, hydrochloric acid bubbler and condenser. Stir to dissolve and add 27.7 g of 4- pyrrolidinobutyronitrile (from 4-chlorobutyronitrile and pyrrolidine). Cool to about 15°-20°C and bubble hydrochloric acid gas in for 4 hours. Cool to about 5°C and add 200 cm3 of water. Stir. Decant the aqueous layer, wash again with 150 cm3 of water. Combine the aqueous layers, drive off the traces of chlorobenzene by distilling 150 cm3 of water, and heat under reflux for one hour. Cool and render alkaline by means of 60 ml of sodium hydroxide solution of 36° Baume. Extract twice with 100 ml of ether. Wash the ether with 100 ml of water. Dry the ether over sodium sulfate and slowly run in 50 ml of 5N hydrogen chloride solution in ether, at the boil. Cool in ice. Filter, wash with ether and dry in a vacuum oven. 33.6 g of crude product are obtained. Recrystallize from 200 ml of isopropanol in the presence of 3 SA carbon black. Filter. Wash and dry in a vacuum oven.
26.9 g of a white, crystalline water-soluble powder are obtained. Yield: 39.2%. Instantaneous melting point: 192°-193°C.

Therapeutic Function

Vasodilator

Buflomedil Preparation Products And Raw materials

Raw materials

Preparation Products

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Buflomedil Suppliers

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55837-25-7, BuflomedilRelated Search:


  • 1-Butanone, 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-
  • 2',4',6'-Trimethoxy-4-(1-pyrrolidinyl)butyrophenone
  • 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanon
  • AURORA KA-850
  • BUFLOMEDIL
  • BufluomedilHcl
  • Buflomedil Hcl 35543-24-9 / Base
  • Buflomedil (base and/or unspecified salts)
  • 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone
  • 4-pyrrolidin-1-yl-1-(2,4,6-trimethoxyphenyl)butan-1-one
  • Buflomedilum
  • 55837-25-7
  • C17H25NO4xHCl
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