ChemicalBook > CAS DataBase List > 1,2,3,4,8,9,10,11-OCTAHYDRO[1,4]DIAZEPINO[6,7,1-JK]CARBAZOLE HYDROCHLORIDE

1,2,3,4,8,9,10,11-OCTAHYDRO[1,4]DIAZEPINO[6,7,1-JK]CARBAZOLE HYDROCHLORIDE

Product Name
1,2,3,4,8,9,10,11-OCTAHYDRO[1,4]DIAZEPINO[6,7,1-JK]CARBAZOLE HYDROCHLORIDE
CAS No.
57756-45-3
Chemical Name
1,2,3,4,8,9,10,11-OCTAHYDRO[1,4]DIAZEPINO[6,7,1-JK]CARBAZOLE HYDROCHLORIDE
Synonyms
WAY 629 hydrochlorid;WAY 629 HYDROCHLORIDE;4,5,6,7,9,10,11,12-Octahydro[1,4]diazepino[6,7,1-jk]carbazole;[1,4]Diazepino[6,7,1-jk]carbazole, 4,5,6,7,9,10,11,12-octahydro-;1,2,3,4,8,9,10,11-OCTAHYDRO[1,4]DIAZEPINO[6,7,1-JK]CARBAZOLE HYDROCHLORIDE
CBNumber
CB1212002
Molecular Formula
C15H18N2
Formula Weight
226.32
MOL File
57756-45-3.mol
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1,2,3,4,8,9,10,11-OCTAHYDRO[1,4]DIAZEPINO[6,7,1-JK]CARBAZOLE HYDROCHLORIDE Property

Melting point:
114-115℃
storage temp. 
Desiccate at +4°C
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
W498708
Product name
WAY629
Packaging
25mg
Price
$220
Updated
2021/12/16
Usbiological
Product number
257097
Product name
WAY 629 hydrochloride
Packaging
10mg
Price
$403
Updated
2021/12/16
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1,2,3,4,8,9,10,11-OCTAHYDRO[1,4]DIAZEPINO[6,7,1-JK]CARBAZOLE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

WAY 629 is a selective SR-2C agonist. Potent and efficacious 5-HT2C receptor agonists.

Definition

ChEBI: LSM-3233 is a member of carbazoles.

Biological Activity

Selective 5-HT 2C agonist. K i values are 56, 2350, 1575 and 815 nM for human recombinant 5-HT 2C , 5-HT 2A , 5-HT 6 and 5-HT 7 receptors respectively. Stimulates intracellular Ca 2+ mobilization in CHO cells expressing human 5-HT 2C receptors (EC 50 = 72 nM). Reduces food intake in rats.

in vivo

WAY 629 (30 mg/kg; i.p.) decreases feeding behavior in rats[1].
WAY 629 (21 mg/kg; i.p.) decreases the expression of NPY mRNA in mice brains[2].

Animal Model:WT mice[2]
Dosage:21 mg/kg
Administration:I.p.
Result:Decreased the expression of NPY mRNA.

IC 50

5-HT2C Receptor: 426 nM (EC50); 5-HT2A Receptor: 260000 nM (EC50)

1,2,3,4,8,9,10,11-OCTAHYDRO[1,4]DIAZEPINO[6,7,1-JK]CARBAZOLE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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1,2,3,4,8,9,10,11-OCTAHYDRO[1,4]DIAZEPINO[6,7,1-JK]CARBAZOLE HYDROCHLORIDE Suppliers

China 11 Germany 2 Switzerland 1 United Kingdom 1 United States 4 Global 19
3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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57756-45-3, 1,2,3,4,8,9,10,11-OCTAHYDRO[1,4]DIAZEPINO[6,7,1-JK]CARBAZOLE HYDROCHLORIDERelated Search:

WASP (B-9) WAPL (A-7) Wash Buffer (20x), 100 mL WATER, ELECTROPHORESIS GRADE N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARAGINE 8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE WAP (E-8) Pyridine hydrochloride Dimethylamine hydrochloride Methylamine hydrochloride Cysteamine hydrochloride 1,2,3,4,8,9,10,11-OCTAHYDRO[1,4]DIAZEPINO[6,7,1-JK]CARBAZOLE HYDROCHLORIDE

  • WAY 629 HYDROCHLORIDE
  • 1,2,3,4,8,9,10,11-OCTAHYDRO[1,4]DIAZEPINO[6,7,1-JK]CARBAZOLE HYDROCHLORIDE
  • 4,5,6,7,9,10,11,12-Octahydro[1,4]diazepino[6,7,1-jk]carbazole
  • [1,4]Diazepino[6,7,1-jk]carbazole, 4,5,6,7,9,10,11,12-octahydro-
  • WAY 629 hydrochlorid
  • 57756-45-3
  • C15H18N2HCl
  • Serotonin receptor