ChemicalBook > CAS DataBase List > 1-Piperidinepropanol

1-Piperidinepropanol

Product Name
1-Piperidinepropanol
CAS No.
104-58-5
Chemical Name
1-Piperidinepropanol
Synonyms
AKOS BC-0904;BUTTPARK 75\06-09;Piperidinepropanol;1-PIPERIDINEPROPANOL;3-Piperidinopropanol;1-Piperidinopropanol;piperidine-1-propanol;3-PIPERIDINOPROPAN-1-OL;3-Piperidino-1-propanol;1-Piperidine-1-propanol
CBNumber
CB1212017
Molecular Formula
C8H17NO
Formula Weight
143.23
MOL File
104-58-5.mol
More
Less

1-Piperidinepropanol Property

Boiling point:
94-95 °C/0.5 mmHg (lit.)
Density 
0.944 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.4775(lit.)
Flash point:
208 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
15.12±0.10(Predicted)
form 
liquid
color 
Colourless to light yellow
InChI
InChI=1S/C8H17NO/c10-8-4-7-9-5-2-1-3-6-9/h10H,1-8H2
InChIKey
PLRXAFVBCHEMGD-UHFFFAOYSA-N
SMILES
N1(CCCO)CCCCC1
CAS DataBase Reference
104-58-5(CAS DataBase Reference)
NIST Chemistry Reference
1-Piperidinepropanol(104-58-5)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
TN2414500
HS Code 
2933399990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
152935
Product name
1-Piperidinepropanol
Purity
97%
Packaging
5g
Price
$150
Updated
2023/06/20
TCI Chemical
Product number
P2973
Product name
3-(Piperidin-1-yl)propan-1-ol
Purity
min. 98.0 %
Packaging
1G
Price
$36
Updated
2025/07/31
TCI Chemical
Product number
P2973
Product name
3-(Piperidin-1-yl)propan-1-ol
Purity
min. 98.0 %
Packaging
5G
Price
$108
Updated
2025/07/31
TRC
Product number
P482403
Product name
1-Piperidinepropanol
Packaging
5g
Price
$100
Updated
2021/12/16
Apolloscientific
Product number
OR24928
Product name
1-(3-Hydroxyprop-1-yl)piperidine
Purity
97%
Packaging
10g
Price
$103
Updated
2021/12/16
More
Less

1-Piperidinepropanol Chemical Properties,Usage,Production

Uses

Reactant in: Mitsunobu reaction of intramolecular nitrile oxide-alkene cycloadditions1 Suzuki-coupling2Reactant for synthesis of: Histamine H3 receptor antagonists3 Protein lysine methyltransferase G9a inhibitors4 Serotonin-4 receptors antagonists5 Checkpoint kinase Chk2 inhibitors6

Uses

1-Piperidinepropanol is used in preparation of Ionizable Amine lipids for lipid Nanoparticle compounds that deliver Nucleic Acids.

Synthesis

23573-93-5

104-58-5

Step 2: Synthesis of 3-(piperidin-1-yl)propanol Anhydrous tetrahydrofuran (80 mL) was added to a dry three-necked flask and the reaction system was cooled to 0 °C. Lithium aluminum hydride (3.5 g, 93.4 mmol) was added to the flask in batches followed by slow dropwise addition of a tetrahydrofuran solution of methyl 3-(piperidin-1-yl)propionate (8.0 g, 46.7 mmol). After the dropwise addition was completed, the reaction mixture was gradually warmed up to room temperature and the reaction was continued with stirring for 2 hours. Upon completion of the reaction, the mixture was re-cooled to 0°C. Purified water (10 mL), 15% aqueous NaOH solution (10 mL) and purified water (30 mL) were added sequentially to the cooled mixture to quench the reaction. The resulting white solid was removed by filtration and the filtrate was concentrated to afford a yellow oily product, 3-(piperidin-1-yl)propanol (4.0 g), which could be used in subsequent steps without further purification.

References

[1] Tetrahedron, 2007, vol. 63, # 52, p. 12903 - 12911
[2] Patent: EP3181554, 2017, A1. Location in patent: Paragraph 0253

1-Piperidinepropanol Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

1-Piperidinepropanol Suppliers

China 112 Germany 3 India 4 Italy 1 South Korea 1 Switzerland 1 United Kingdom 3 United States 22 Global 147
Hunan Caiya Biological Technology Co., Ltd
Tel
15580017485
Email
2036676503@qq.com
Country
China
ProdList
91
Advantage
58
Shanghai Aladdin Biochemical Technology Co.,Ltd.
Tel
400-6206333 13167063860
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
48457
Advantage
58
Shanghai Langruibang Pharmaceutical Technology Co., Ltd
Tel
010-88755821 18612220856
Email
marketing@langrb.com
Country
China
ProdList
413
Advantage
58
Huaian Jiamu Biotechnology Co., Ltd.
Tel
0517-83187139 18205232085
Email
cai@jiamu-bio.com
Country
China
ProdList
2996
Advantage
58
Suzhou Vosun Biotech Co.,Ltd
Tel
18934576691
Fax
0512-82177265
Email
yq@vosunbio.com
Country
China
ProdList
735
Advantage
58
PharmaBlock Sciences (Nanjing),Inc.
Tel
025-86918202 4000255188
Fax
86-025-86918232
Email
sales@pharmablock.com
Country
China
ProdList
5000
Advantage
55
Sichuan Tongsheng Amino acids Co.,Ltd.
Tel
0838-2274206 13908101207
Fax
+86-838-2274207
Email
sales@biots.cn
Country
China
ProdList
279
Advantage
66
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14101
Advantage
59
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
16077
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
ZhengZhou HuaWen Chemical Co.Ltd
Tel
0370-2785118 17550508557
Fax
QQ：3470079902
Email
675141927@qq.com
Country
China
ProdList
3199
Advantage
55
Nanjing JinruiJiuAn Biotechnology Co., Ltd.
Tel
025-58196018 800028039
Fax
025-83453306
Email
sales@fartop.net
Country
China
ProdList
2229
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Deyang Yuehe Bio-Pharmaceutical Co.,Ltd
Tel
028-82729560 18030702676
Fax
028-82729560
Email
sales@yuehepharm.com
Country
China
ProdList
179
Advantage
58
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883
Fax
0731-82251112
Email
sales@huatengsci.com
Country
China
ProdList
5872
Advantage
58
Suzhou yacoo science co.,Ltd
Tel
0512-87182056 18013166090
Fax
0512-87182056
Email
lingling.qi@yacoo.com.cn
Country
China
ProdList
6295
Advantage
60
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10263
Advantage
55
Shanghai Qinghang Chemical Co. Ltd.
Tel
021-50840321, 18601625411
Fax
021-50840321
Email
thomasleehz@hotmail.com
Country
China
ProdList
216
Advantage
50
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Infinity SCI
Tel
400-106-2016 17800804092
Email
admin@infsci.com
Country
China
ProdList
553
Advantage
55
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
Shanghai RenYue Chemical Technology Co., Ltd.
Tel
021-62219190; 18321139117
Email
316441092@qq.com
Country
China
ProdList
2912
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Changzhou Hopschain Chemical Co.,Ltd.
Tel
0519-85528066 13775048983
Fax
0519-85528066
Email
sales@hopschem.com
Country
China
ProdList
31553
Advantage
55
parabiochem
Tel
025-83453382-8005
Fax
025-83453382
Email
sale@parabiochem.com
Country
China
ProdList
9595
Advantage
55
Taian Jiaye Biotechnology Co.Ltd
Tel
13127280945
Email
285424065@qq.com
Country
China
ProdList
9976
Advantage
55
Shandong Ono Chemical Co., Ltd.
Tel
0539-6362799 20）
Fax
0539-6362799（To 20）
Country
China
ProdList
9998
Advantage
58
Jiaxing Deyi Chemical Co., Ltd.
Tel
86-0573-85866609 13325730825
Fax
0573-85866609
Email
945717149@qq.com
Country
China
ProdList
8595
Advantage
58
Aikon International Limited
Tel
025-58859352 18068836627
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
16027
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 400821072
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25000
Advantage
58
Jinan Kabotang Biological Technology Co.,Ltd.
Tel
0531-61320525 15866703830
Email
figo.gao@foxmail.com
Country
China
ProdList
5177
Advantage
58
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-037163312495,13303845143 13303845143
Fax
QQ3001379618
Email
3001379618@qq.com
Country
China
ProdList
10267
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Cool Pharm, Ltd
Tel
021-58581007 18019463053
Fax
021-50966098
Email
sales@coolpharm.com
Country
China
ProdList
12878
Advantage
58
Beijing Minruida Technology Co., Ltd.
Tel
010-82387566 18001021521;
Fax
82387566-801
Email
sales@mreda.com.cn
Country
China
ProdList
10083
Advantage
58
Hunan chemfish Scientific co.,ltd
Tel
19313119705 15707487186
Email
sales@chemfish.com
Country
China
ProdList
4961
Advantage
58
Zhengzhou Alfa Chemical Co.,Ltd
Tel
+8618530059196
Email
sale04@alfachem.cn
Country
China
ProdList
11784
Advantage
58
ANHUI WITOP BIOTECH CO., LTD
Tel
+8615255079626
Email
eric@witopchemical.com
Country
China
ProdList
23541
Advantage
58
Nanjing Hengbei Chemicals Co., Ltd.
Tel
+86-25-58393656
Fax
+86-25-58393656
Email
sales@hengbeichem.cn
Country
China
ProdList
6854
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418671 +8618949823763
Fax
0551-65418697
Email
sales@tnjchem.com
Country
China
ProdList
34563
Advantage
58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
+86-0571-88938639 +8617705817739
Fax
+86-571-88938652，+86-571- 88492614
Email
info@dycnchem.com
Country
China
ProdList
52846
Advantage
58
Changzhou Ditong Chemical Co.,Ltd
Tel
+86-0519-88299272
Email
info@edengenechem.com
Country
China
ProdList
2176
Advantage
58
Changzhou ruiqing medical technology co., LTD
Tel
0519-85859396 15380475813
Email
656870630@qq.com
Country
China
ProdList
485
Advantage
58
Chongqing Chemdad Co., Ltd
Tel
+86-023-6139-8061 +86-86-13650506873
Email
sales@chemdad.com
Country
China
ProdList
39927
Advantage
58
Nanjing chemical reagent co. LTD
Tel
025-58369808 17895012682
Fax
025-85312034
Email
3236925839@qq.com
Country
China
ProdList
3526
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49975
Advantage
58
More
Less

View Lastest Price from 1-Piperidinepropanol manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
1-Piperidinepropanol 104-58-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
1-Piperidinepropanol 97% 104-58-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
1-Piperidinepropanol 104-58-5
Price
US $1.00/g
Min. Order
1g
Purity
96%-98%
Supply Ability
1000KGS
Release date
2019-12-20

104-58-5, 1-PiperidinepropanolRelated Search:

Haloperidol 1-Propanol Triacetonediamine DROPERIDOL Diphenoxylate 3-PIPERIDINO-1,2-PROPANEDIOL VERATRIDINE Benzhexol hydrochloride SWAINSONINE 1-PIPERIDINEPROPIONIC ACID S(+)-NIGULDIPINE HYDROCHLORIDE SPIROXATRINE alpha-Cyclohexyl-alpha-phenyl-1-piperidinepropanol,1-Piperidinepropanol, alpha-cyclohexyl-alpha-phenyl- DL-TRIHEXYPHENIDYL HYDROCHLORIDE 4-Piperidinepropanol, 1-(2-hydroxyethyl)- 1-piperidinepropanol,2-methyl-,3,4-dichlorobenzoate(ester Cevadine B-PIPERIDINOPROPIONALDEHYDE DIMETHYL ACETAL

  • BUTTPARK 75\06-09
  • 1-PIPERIDINEPROPANOL
  • 3-PIPERIDINOPROPAN-1-OL
  • 3-N-PIPERIDINO-1-PROPANOL
  • AKOS BC-0904
  • 1-(3-Hydroxypropyl)piperidine
  • 1-Propanol, 3-piperidino-
  • 3-(1-Piperidino)propanol
  • 3-(1-Piperidinyl)propanol
  • 3-Piperidino-1-propanol
  • 3-Piperidinopropanol
  • gamma-Piperidinopropanol
  • piperidine-1-propanol
  • 1-PIPERIDINEPROPANOL 97%
  • 3-N-PIPERIDINO-1-PROPANOL 95%
  • 1-Piperidine-1-propanol
  • 3-piperidin-1-ylpropan-1-ol
  • 1-(3-Hydroxyprop-1-yl)piperidine
  • 3-(Piperidin-1-yl)propan-1-ol, 1-Hydroxy-3-(piperidin-1-yl)propane
  • 3-(1-piperidyl)propan-1-ol
  • gamma-Piperidinopropanol [German]
  • 1-(3-Hydroxyprop-1-yl)piperidine 97%
  • N-(3-Hydroxypropyl) piperidine
  • Piperidinepropanol
  • 1-Piperidinepropanol (6CI, 7CI, 8CI, 9CI, ACI)
  • 1-Piperidinopropanol
  • 104-58-5
  • Heterocyclic Building Blocks
  • Piperidines
  • ALCOHOL
  • Building Blocks
  • Building Blocks
  • C8
  • Chemical Synthesis
  • Heterocyclic Building Blocks
  • Building Blocks
  • Heterocyclic Building Blocks
  • Piperidines