1-Piperidinepropanol
- Product Name
- 1-Piperidinepropanol
- CAS No.
- 104-58-5
- Chemical Name
- 1-Piperidinepropanol
- Synonyms
- AKOS BC-0904;BUTTPARK 75\06-09;Piperidinepropanol;1-PIPERIDINEPROPANOL;3-Piperidinopropanol;1-Piperidinopropanol;piperidine-1-propanol;3-PIPERIDINOPROPAN-1-OL;3-Piperidino-1-propanol;1-Piperidine-1-propanol
- CBNumber
- CB1212017
- Molecular Formula
- C8H17NO
- Formula Weight
- 143.23
- MOL File
- 104-58-5.mol
1-Piperidinepropanol Property
- Boiling point:
- 94-95 °C/0.5 mmHg (lit.)
- Density
- 0.944 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.4775(lit.)
- Flash point:
- 208 °F
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 15.12±0.10(Predicted)
- form
- liquid
- color
- Colourless to light yellow
- InChI
- InChI=1S/C8H17NO/c10-8-4-7-9-5-2-1-3-6-9/h10H,1-8H2
- InChIKey
- PLRXAFVBCHEMGD-UHFFFAOYSA-N
- SMILES
- N1(CCCO)CCCCC1
- CAS DataBase Reference
- 104-58-5(CAS DataBase Reference)
- NIST Chemistry Reference
- 1-Piperidinepropanol(104-58-5)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 152935
- Product name
- 1-Piperidinepropanol
- Purity
- 97%
- Packaging
- 5g
- Price
- $150
- Updated
- 2023/06/20
- Product number
- P2973
- Product name
- 3-(Piperidin-1-yl)propan-1-ol
- Purity
- min. 98.0 %
- Packaging
- 1G
- Price
- $36
- Updated
- 2025/07/31
- Product number
- P2973
- Product name
- 3-(Piperidin-1-yl)propan-1-ol
- Purity
- min. 98.0 %
- Packaging
- 5G
- Price
- $108
- Updated
- 2025/07/31
- Product number
- P482403
- Product name
- 1-Piperidinepropanol
- Packaging
- 5g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- OR24928
- Product name
- 1-(3-Hydroxyprop-1-yl)piperidine
- Purity
- 97%
- Packaging
- 10g
- Price
- $103
- Updated
- 2021/12/16
1-Piperidinepropanol Chemical Properties,Usage,Production
Uses
Reactant in: Mitsunobu reaction of intramolecular nitrile oxide-alkene cycloadditions1 Suzuki-coupling2Reactant for synthesis of: Histamine H3 receptor antagonists3 Protein lysine methyltransferase G9a inhibitors4 Serotonin-4 receptors antagonists5 Checkpoint kinase Chk2 inhibitors6
Uses
1-Piperidinepropanol is used in preparation of Ionizable Amine lipids for lipid Nanoparticle compounds that deliver Nucleic Acids.
Synthesis
23573-93-5
104-58-5
Step 2: Synthesis of 3-(piperidin-1-yl)propanol Anhydrous tetrahydrofuran (80 mL) was added to a dry three-necked flask and the reaction system was cooled to 0 °C. Lithium aluminum hydride (3.5 g, 93.4 mmol) was added to the flask in batches followed by slow dropwise addition of a tetrahydrofuran solution of methyl 3-(piperidin-1-yl)propionate (8.0 g, 46.7 mmol). After the dropwise addition was completed, the reaction mixture was gradually warmed up to room temperature and the reaction was continued with stirring for 2 hours. Upon completion of the reaction, the mixture was re-cooled to 0°C. Purified water (10 mL), 15% aqueous NaOH solution (10 mL) and purified water (30 mL) were added sequentially to the cooled mixture to quench the reaction. The resulting white solid was removed by filtration and the filtrate was concentrated to afford a yellow oily product, 3-(piperidin-1-yl)propanol (4.0 g), which could be used in subsequent steps without further purification.
References
[1] Tetrahedron, 2007, vol. 63, # 52, p. 12903 - 12911
[2] Patent: EP3181554, 2017, A1. Location in patent: Paragraph 0253
1-Piperidinepropanol Preparation Products And Raw materials
Raw materials
Preparation Products
1-Piperidinepropanol Suppliers
- Tel
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- Country
- Switzerland
- ProdList
- 6896
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View Lastest Price from 1-Piperidinepropanol manufacturers
- Product
- 1-Piperidinepropanol 104-58-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- 1-Piperidinepropanol 97% 104-58-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 1-Piperidinepropanol 104-58-5
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 96%-98%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-20