(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE

Product Name: (R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE
CAS No.: 131685-53-5
Chemical Name: (R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE
Synonyms: (R)-3-(1-Oxopropyl)-4-b;R-4-Benzyl-3-Propiony-2-Oxazolidinone;N-PROPIONYL-(4R)-BENZYL-2-OXAZOLIDINONE;(R)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE;(-)-4-Benzyl-3-propionyl-2-oxazolidinone;(R)-4-benzy1-3-propionyloxazolidin-2-one;(4R)-4-Benzyl-3-propionyloxazolidin-2-one;N-3-PROPIONYL-(4R)-BENZYL-2-OXAZOLIDINONE;(4R)-4-benzyl-3-propanoyl-1,3-oxazolidin-2;(R)-(-)-4-Benzyl-3-propiomyl-2-oxazolidinone
CBNumber: CB1217072
Molecular Formula: C13H15NO3
Formula Weight: 233.26
MOL File: 131685-53-5.mol

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(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE Property

Melting point:: 45 °C
Boiling point:: 396.6±11.0 °C(Predicted)
Density: 1.206±0.06 g/cm3(Predicted)
refractive index: -103 ° (C=1, EtOH)
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform, Ethanol
pka: -2.35±0.40(Predicted)
form: Solid
color: Off-White
optical activity: [α]20/D 102°, c = 1 in ethanol
InChI: InChI=1S/C13H15NO3/c1-2-12(15)14-11(9-17-13(14)16)8-10-6-4-3-5-7-10/h3-7,11H,2,8-9H2,1H3/t11-/m1/s1
InChIKey: WHOBYFHKONUTMW-LLVKDONJSA-N
SMILES: O1C[C@@H](CC2=CC=CC=C2)N(C(=O)CC)C1=O
CAS DataBase Reference: 131685-53-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-36-24/25
WGK Germany: 3
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 459542
Product name: (R)-(?)-4-Benzyl-3-propionyl-2-oxazolidinone
Purity: 99%
Packaging: 1g
Price: $54.2
Updated: 2023/01/07

Sigma-Aldrich

Product number: 459542
Product name: (R)-(?)-4-Benzyl-3-propionyl-2-oxazolidinone
Purity: 99%
Packaging: 5g
Price: $224
Updated: 2023/01/07

TCI Chemical

Product number: B2165
Product name: (R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone
Purity: >98.0%(GC)
Packaging: 1g
Price: $79
Updated: 2025/07/31

TCI Chemical

Product number: B2165
Product name: (R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone
Purity: >98.0%(GC)
Packaging: 5g
Price: $236
Updated: 2025/07/31

Sigma-Aldrich

Product number: 459542
Product name: (R)-(?)-4-Benzyl-3-propionyl-2-oxazolidinone
Purity: 99%
Packaging: 25g
Price: $1090
Updated: 2023/06/20

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(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

(R)-(?)-4-Benzyl-3-propionyl-2-oxazolidinone can be used as a building block for the preparation of methyl 3-[(S)-3-((R)-4-benzyl-2-oxooxazolidin-3-yl)-2-methyl-3-oxopropyl]benzoate by treating with strong base followed by the addition of methyl 3-bromomethyl benzoate.

Uses

(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE is a oxazolidinone derivative used in the preparation of anisomycin analogues as activators of the JNK/SAPK1 and p38/SAPK2 pathways.

General Description

(R)-(?)-4-Benzyl-3-propionyl-2-oxazolidinone is used as a building block in organic synthesis for the preparation of oxazolidinone derivatives.

Synthesis

90719-32-7

79-03-8

131685-53-5

Under nitrogen protection, (S)-4-benzyl-2-azolidinone (800 mg, 4.5 mmol) was dissolved in a dry reaction vial of anhydrous tetrahydrofuran (30 mL) and cooled to -78 °C in a dry ice/acetone bath. A hexane solution of 1.6 M n-butyllithium (5.0 mmol, 3.1 mL) was added slowly and dropwise over 3 min. After stirring for 30 min, propionyl chloride (5.0 mmol, 0.43 mL) was added slowly over 3 min. The reaction solution was slowly warmed to room temperature over 14 h. The reaction was subsequently quenched by the addition of saturated ammonium chloride solution (10 mL) and water (30 mL). The aqueous layer was extracted with ethyl acetate (3 x 40 mL), the organic phases were combined and dried over anhydrous magnesium sulfate. The organic phase was concentrated under reduced pressure to afford (R)-(-)-benzyl-3-propionyl-2-oxazolidinone (oil, 1.0 g, 96% yield) with >95% purity by HPLC.1H NMR (500 MHz, CDCl3): δ 7.33 (dd, J1 = 7.4 Hz, J2 = 7.6 Hz, 2H), 7.29 (d, J = 6.9 Hz, 1H) ), 7.21 (d, J = 7.4 Hz, 2H), 4.67 (m, 1H), 4.18 (m, 2H), 3.31 (dd, J1 = 13.3 Hz, J2 = 3.2 Hz, 1H), 2.96 (m, 2H), 2.77 (dd, J1 = 13.3 Hz, J2 = 3.7 Hz, 1H), 1.21 (t, J = 7.4 Hz, 1H). 3H).

References

[1] Chemistry - An Asian Journal, 2011, vol. 6, # 7, p. 1791 - 1799
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 1, p. 144 - 148
[3] Journal of Organic Chemistry, 2008, vol. 73, # 8, p. 3292 - 3294
[4] Angewandte Chemie - International Edition, 2016, vol. 55, # 13, p. 4252 - 4255
[5] Angew. Chem., 2016, vol. 128, # 13, p. 4324 - 4327,4

(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: (R)-4-benzy1-3-propionyloxazolidin-2-one 131685-53-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

Zhuozhou Wenxi import and Export Co., Ltd

Product: (R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE 131685-53-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: (R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE 131685-53-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-07-03

131685-53-5, (R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONERelated Search:

(4S)-(+)-4-Benzyl-3-propionyl-2-oxazolidinone (R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE (R)-4-BENZYL-3-(3-CYCLOPROPYL-PROPIONYL)-OXAZOLIDIN-2-ONE (R)-4-BENZYL-3-(4-METHYL-PENTANOYL)-OXAZOLIDIN-2-ONE (3S,4R)-4-BENZYL-3-(3-METHYLPENTANOYL)-OXAZOLIDIN-2-ONE 3-[(4-METHOXYPHENYL)ACETYL]-(4R)-(PHENYLMETHYL)-2-OXAZOLIDINONE 3-(2-PHENYLACETYL)-(4R)-(PHENYLMETHYL)-2-OXAZOLIDINONE 3-(4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-4-methyl-hexanoic acid tert-butyl ester (R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one (R)-4-BENZYL-3-(3-CYCLOPENTYL-PROPIONYL)-OXAZOLIDIN-2-ONE

(R)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE

N-PROPIONYL-(4R)-BENZYL-2-OXAZOLIDINONE

N-3-PROPIONYL-(4R)-BENZYL-2-OXAZOLIDINONE

(R)-(-)-4-Benzyl-3-propiomyl-2-oxazolidinone

(4R)-4-benzyl-3-propanoyl-1,3-oxazolidin-2-one

(-)-4-Benzyl-3-propionyl-2-oxazolidinone

(4R)-4-Benzyl-3-propionyl-1,3-oxazolidin-2-one

(4R)-4-Benzyl-3-propionyloxazolidin-2-one

(R)-3-(1-Oxopropyl)-4-(phenylMethyl)-2-oxazolidinone

(R)-3-(1-Oxopropyl)-4-b

R-4-Benzyl-3-Propiony-2-Oxazolidinone

(R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone≥ 99% (HPLC)

(R)-4-Benzyl-3-propionyl-2-oxazolidinone,99%e.e.

(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE

(4R)-4-benzyl-3-propanoyl-1,3-oxazolidin-2

(R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone, ee: 99%

(R)-4-Benzyl-3-propionyloxazolidin-2-one 97%

(R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone &gt

2-Oxazolidinone, 3-(1-oxopropyl)-4-(phenylmethyl)-, (4R)-

(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE USP/EP/BP

(R)-4-benzy1-3-propionyloxazolidin-2-one

(R)-4-benzyl-3-propionyloxazolidin-2-one 99.72%( (R)?-?(-?)?-?4-?Benzyl-?3-?propionyl-?2-?oxazolidinone)

(<i>R</i>)-(?)-4-Benzyl-3-propionyl-2-oxazolidinone

131685-53-5

Chiral Building Blocks

Asymmetric Synthesis

Glycidyl Compounds, etc. (Chiral)

Oxazolidinone Derivatives

Chiral Auxiliaries

Aromatics

Chiral Reagents

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Oxazolidinone

chiral

Asymmetric Synthesis

Chiral Building Blocks

Glycidyl Compounds, etc. (Chiral)

Synthetic Organic Chemistry

Peptide

Asymmetric Synthesis

Chiral Auxiliaries

Oxazolidinone Derivatives