ChemicalBook > CAS DataBase List > 6,7-Dimethoxy-1-tetralone

6,7-Dimethoxy-1-tetralone

Product Name
6,7-Dimethoxy-1-tetralone
CAS No.
13575-75-2
Chemical Name
6,7-Dimethoxy-1-tetralone
Synonyms
4-dihydro-6;7-diMethoxy-;6,7-DIMETHOXY-1-TETRALONE;6,7-dimethoxytetralin-1-one;6,7-Dimethoxy-1-tetralone 97%;6,7-DIMETHOXY-1-TETRALONE, 97%%;6,7-Dimethoxy-3,4-dihydro-2H-naphthalen-1-one;6,7-diMethoxy-3,4-dihydronaphthalen-1(2H)-one;3,4-Dihydro-6,7-dimethoxy-1(2H)-naphthalenone;1(2H)-Naphthalenone, 3,4-dihydro-6,7-dimethoxy-
CBNumber
CB1218024
Molecular Formula
C12H14O3
Formula Weight
206.24
MOL File
13575-75-2.mol
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6,7-Dimethoxy-1-tetralone Property

Melting point:
98-100 °C(lit.)
Boiling point:
358.3±42.0 °C(Predicted)
Density 
1.140±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
Crystalline Powder or Crystals
color 
White to off-white
CAS DataBase Reference
13575-75-2(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
273937
Product name
6,7-Dimethoxy-1-tetralone
Purity
97%
Packaging
1g
Price
$100
Updated
2025/07/31
Sigma-Aldrich
Product number
273937
Product name
6,7-Dimethoxy-1-tetralone
Purity
97%
Packaging
5g
Price
$582
Updated
2023/06/20
TCI Chemical
Product number
D6363
Product name
6,7-Dimethoxy-3,4-dihydronaphthalen-1(2H)-one
Purity
min. 95.0 %
Packaging
1G
Price
$99
Updated
2025/07/31
TRC
Product number
B429603
Product name
6,7-Dimethoxy-1-tetralone
Packaging
500mg
Price
$130
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD149587
Product name
6,7-Dimethoxy-1-tetralone
Packaging
500mg
Price
$60
Updated
2021/12/16
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6,7-Dimethoxy-1-tetralone Chemical Properties,Usage,Production

Uses

6,7-Dimethoxy-1-tetralone was used in the synthesis of 2-bromotetralones by undergoing bromination. It was also used as a precursor to quinolines with dopaminergic activity, naphthols with anti-inflammatory activity and benzophenanthridine alkaloids with antitumor activity.

Synthesis Reference(s)

Tetrahedron Letters, 24, p. 2939, 1983 DOI: 10.1016/S0040-4039(00)88063-6

General Description

6,7-Dimethoxy-1-tetralone reacts with 2-amino-4,5-dimethoxyacetophenone to form 5,6-dihydro-2,3,9,10-tetramethoxybenz[c]acridine.

Synthesis

13575-74-1

13575-75-2

General procedure for the synthesis of 6,7-dimethoxy-3,4-dihydronaphthalen-1(2H)-one from 4-(3,4-dimethoxyphenyl)butyric acid: polyphosphoric acid (210 g) was added to a solution of dichloromethane (50 mL) in which 4-(3,4-dimethoxyphenyl)butyric acid (0.19 mol, 42 g) was dissolved, and the mixture was heated for 2 hr under reflux conditions. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and the residue was slowly poured into crushed ice. The pH of the solution was adjusted to 7-8 with alkali, and the precipitate precipitated was filtered and dried to give 6,7-dimethoxy-3,4-dihydronaphthalen-1(2H)-one (36 g, 93.3% yield) as a white solid with a melting point of 94-96 °C (literature value: 96-98 °C).1H NMR (400 MHz, CDCl3): δ 7.51 (s, 1H), 6.67 (s 1H), 3.93 (s, 3H), 3.91 (s, 3H), 2.89 (t, J=6Hz, 2H), 2.60 (t, J=6.4Hz, 2H), 2.15-2.09 (m, 2H); 13C NMR (101MHz, CDCl3): δ197.10, 153.51, 147.96, 139.27 125.79, 110.22, 108.57, 55.98, 38.50, 29.44, 23.61.

References

[1] Synthetic Communications, 2009, vol. 39, # 15, p. 2664 - 2673
[2] Journal of Organic Chemistry, 1985, vol. 50, # 24, p. 4933 - 4938
[3] European Journal of Medicinal Chemistry, 2012, vol. 53, p. 52 - 63
[4] Pharmazie, 1981, vol. 36, # 2, p. 88 - 91
[5] Tetrahedron Letters, 2009, vol. 50, # 13, p. 1407 - 1410

6,7-Dimethoxy-1-tetralone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 6,7-Dimethoxy-1-tetralone manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
6,7-Dimethoxy-1-tetralone 13575-75-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
6,7-Dimethoxy-1-tetralone 13575-75-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
6,7-Dimethoxy-1-tetralone 13575-75-2
Price
US $1.00/KG
Min. Order
1KG
Purity
90%-99.9%
Supply Ability
500kg
Release date
2019-07-12

13575-75-2, 6,7-Dimethoxy-1-tetraloneRelated Search:

Dimethyldimethoxysilane 1,1-Dimethoxyethane 1-Tetralone 1,2,3,4-Tetrahydronaphthalene Naphthalene 1,8-Naphthalic anhydride Dimethoxymethane 6-Hydroxy-1-tetralone 7-Hydroxy-1-tetralone 6-methoxy-1-tetralone 6,7-DIMETHOXY-2-TETRALONE 7-Methoxy-1-tetralone 6-METHOXY-1,2,3,4-TETRAHYDRONAPHTHALENE 5 8-DIMETHOXY-1-TETRALONE 99 6,8-Dimethoxyl-2-tetralone 5,8-dimethoxy-2-tetralone 6-METHYLISOVANILLIN 1-(4,5-DIMETHOXY-2-METHYLPHENYL)ETHAN-1-ONE

  • 6,7-DIMETHOXY-1-TETRALONE
  • 6,7-DIMETHOXY-1-TETRALONE, 97%%
  • 6,7-Dimethoxy-3,4-dihydro-2H-naphthalen-1-one
  • 6,7-dimethoxytetralin-1-one
  • 4-dihydro-6
  • 7-diMethoxy-
  • 6,7-diMethoxy-3,4-dihydronaphthalen-1(2H)-one
  • 6,7-Dimethoxy-1-tetralone 97%
  • 1(2H)-Naphthalenone, 3,4-dihydro-6,7-dimethoxy-
  • 3,4-Dihydro-6,7-dimethoxy-1(2H)-naphthalenone
  • 13575-75-2
  • C11 to C12
  • Carbonyl Compounds
  • Building Blocks
  • Ketones
  • Organic Building Blocks
  • C11 to C12
  • Carbonyl Compounds
  • Ketones