Hydrocortisone-17-butyrate

Product Name: Hydrocortisone-17-butyrate
CAS No.: 13609-67-1
Chemical Name: Hydrocortisone-17-butyrate
Synonyms: HYDROCORTISONE BUTYRATE;HYDROCORTISONE 17-BUTYRATE;Alfason;h.17b;locoid;Plancol;Laticort;hb(sub17);Nicotine Impurity 8;CORTISOL 17-BUTYRATE
CBNumber: CB1230781
Molecular Formula: C25H36O6
Formula Weight: 432.56
MOL File: 13609-67-1.mol

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Hydrocortisone-17-butyrate Property

Melting point:: 210.0 to 214.0 °C
Boiling point:: 466.2°C (rough estimate)
Density: 1.0914 (rough estimate)
refractive index: 1.4593 (estimate)
storage temp.: Refrigerator
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 12.98±0.10(Predicted)
form: Solid
color: White to Off-White
Merck: 14,4787
InChIKey: BMCQMVFGOVHVNG-IZBZUILHNA-N
SMILES: O([C@@]1(CC[C@@]2([H])[C@]3([H])CCC4=CC(=O)CC[C@]4(C)[C@@]3([H])[C@@H](O)C[C@]12C)C(=O)CO)C(=O)CCC |&1:1,4,6,16,18,20,23,r|
CAS DataBase Reference: 13609-67-1(CAS DataBase Reference)

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Safety

WGK Germany: 2
RTECS: GM9002000
HS Code: 2937290000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H5270
Product name: Hydrocortisone 17-butyrate
Packaging: 1g
Price: $132
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1317302
Product name: Hydrocortisone butyrate
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $436
Updated: 2024/03/01

TCI Chemical

Product number: H1506
Product name: Hydrocortisone 17-Butyrate
Purity: >98.0%(HPLC)
Packaging: 200mg
Price: $40
Updated: 2024/03/01

TCI Chemical

Product number: H1506
Product name: Hydrocortisone 17-Butyrate
Purity: >98.0%(HPLC)
Packaging: 1g
Price: $125
Updated: 2024/03/01

TRC

Product number: H714605
Product name: Hydrocortisone butyrate
Packaging: 2.5g
Price: $160
Updated: 2021/12/16

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Hydrocortisone-17-butyrate Chemical Properties,Usage,Production

Description

Hydrocortisone 17-butyrate: a new non-fluorinated topical corticosteroid.
Hydrocortisone 17-butyrate could be used in psoriasis, eczema and other inflammatory dermatoses. It may be found in creams, lotions, ointments, and powders and in ear, nose and eye drops for rhinitis, otitis, and conjunctivitis. In double-blind paired comparisons with other topical corticosteroids, the efficacy of hydrocortisone 17-butyrate 0.1% has generally been indistinguishable from that of triamcinolone acetonide 0.1%, fluocinolone acetonide 0.025% or betamethasone 17-valerate 0.1% in patients with eczema or psoriasis. When applied to the face of patients with atrophy superimposed on rosacea and perioral dermatitis resulting from prolonged use of fluorinated topical corticosteroids, hydrocortisone 17-butyrate 0.1% did not prevent the beneficial effect of systemic tetracycline nor the disappearance of telangiectasis and tended to be more effective than hydrocortisone 1%[1].

Uses

Hydrocortisone Butyrate is a topical corticosteroid use to treat a variety of dermatological conditions. It acts as an antiinflammatory, antiproliferative and immunosuppresive agent.

Uses

antineoplastic

Uses

Hydrocortisone-17-butyrate is a topical corticosteroid with anti-inflammatory properties; marker for topical corticosteroid allergy.

Definition

ChEBI: Cortisol esterified with butyric acid at the 17-hydroxy group.

brand name

Locoid (Ferndale); Locoid (Yamanouchi).

Contact allergens

Hydrocortisone 17-butyrate is a C 17 ester of hydrocorti- sone. It represents the D2 group of corticosteroids, non C 16 methylated with a C 17 ester: hydrocortisone 17-butyrate, hydrocortisone 17-valerate, hydrocortisone aceponate (17-propionate and 21-acetate), methylpred- nisolone aceponate, and prednicarbate. It is sometimes hydrolyzed in vivo into hydrocortisone, giving allergic reactions to group-A-sensitized people.

Biochem/physiol Actions

Hydrocortisone 17-butyrate is a corticosteroid that acts as a dermocorticoid due to its application in dermatological therapy. It exhibits therapeutic effects against vitiligo of the face and neck.

References

[1] R N Brogden. “Hydrocortisone 17-butyrate: a new topical corticosteroid preliminary report.” ACS Chemical Neuroscience 12 4 (1976): 249–57.

Hydrocortisone-17-butyrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Hydrocortisone-17-butyrate Suppliers

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View Lastest Price from Hydrocortisone-17-butyrate manufacturers

Hebei Kangcang new material Technology Co., LTD

Product: Hydrocortisone-17-butyrate 13609-67-1
Price: US $20.00-10.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 20
Release date: 2024-03-20

Hebei Kangcang new material Technology Co., LTD

Product: Hydrocortisone 17-butyrate 13609-67-1
Price: US $9.00-60.00/g
Min. Order: 10g
Purity: 99%
Supply Ability: 10 tons
Release date: 2024-03-22

Zhuozhou Wenxi import and Export Co., Ltd

Product: Hydrocortisone-17-butyrate 13609-67-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

13609-67-1, Hydrocortisone-17-butyrateRelated Search:

Flumethasone Progesterone Hydrocortisone 3,20-Dioxopregn-4-en-17-beta-yl acetate Hydrocortisone-17-butyrate FEMA 3332 CORTEXOLONE CORTICOSTERONE CORTISONE Butyric Acid 11BETA-HYDROXYPROGESTERONE Desoxycorticosterone Amebucort Hydrocortisone Butyrate Propionate CORTISOL 17-VALERATE 11BETA,17ALPHA-DIHYDROXY-4-PREGNENE-3,20-DIONE 3-ACETOXY-3-METHYL-2-BUTANONE 17ALPHA-HYDROXYPROGESTERONE

HYDROCORTISONE 17-BUTYRATE

HYDROCORTISONE BUTYRATE

CORTISOL 17-BUTYRATE

11b,17,21-trihydroxypregn-4-ene-3,20-dione 17-butyrate

11BETA,17,21-TRIHYDROXYPREGN-4-ENE-3,20-DIONE 17-BUTYRATE

11-beta,17-alpha,21-trihydroxy-4-pregnene-3,20-dione17-alpha-butyrate

h.17b

hb(sub17)

hydrocortisone17-alpha-butyrate

Hydrocortisone butyrate 13609-67-1

locoid

Hydrocortisone Butyrate USP

4-Pregnene-11β,21-dihydroxy-17α-butyryloxy-3,20-dione

Alfason

Butyric acid, 17-ester with cortisol (8CI)

Cortisol, 17-butyrate (6CI, 8CI)

Laticort

Plancol

Pregn-4-ene-3,20-dione, 11,21-dihydroxy-17-(1-oxobutoxy)-, (11β)-

21-dihydroxy-17-(1-oxobutoxy)-20-dion (11-beta)-pregn-4-ene-11

11β,17,21-Trihydroxypregn-4-ene-3,20-dione 17-butyrate, Cortisol 17-butyrate

17α-(Butyryloxy)corticosterone

Hydrocortisone Butyrate (200 mg)

Hydrocortisone-17-bu

2-((8S,9S,10R,11S,13S,14S,17R)-11,17-Dihydroxy-10,13-diMethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-Tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl butyrate

Pregn-4-ene-3,20-dione, 11,21-dihydroxy-17-(1-oxobutoxy)-, (11.beta.)-

11β,17,21-trihydroxypregn-4-ene-3,20-dione 17-butyrate

Hydrocortisone17-Butyrate&gt

Hydrocortisone-17-butyrate USP/EP/BP

Hydrocortisone Butyrater

Hydrocortisone Butyrate (1317302)

4-PREGNEN-11β, 17, 21-TRIOL-3, 20-DIONE-17-BUTYRATE

(8S,9S,10R,11S,13S,14S,17R)-11-Hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl butyrate

C14224030 HydrocortisonE17-Butyrate

Nicotine Impurity 8

13609-67-1

609-67-1

3609-67-1

C25H36O6

BioChemical

Cell Biology

Steroid Hormones

Hormones

Cytokines, Growth Factors and Hormones

Cell Signaling and Neuroscience

NOVANTRONE

Steroid and Hormone

Steroids

13609-67-1