L-MIMOSINE
- Product Name
- L-MIMOSINE
- CAS No.
- 500-44-7
- Chemical Name
- L-MIMOSINE
- Synonyms
- MIMOSINE;LEUCENOL;leucenine;NSC 69188;L-MIMOSINE;L-LEUCININE;Mimosine 99%;Mimosine,99%;L(-)-MIMOSINE;MimosineLeucenol
- CBNumber
- CB1234466
- Molecular Formula
- C8H10N2O4
- Formula Weight
- 198.18
- MOL File
- 500-44-7.mol
L-MIMOSINE Property
- Melting point:
- 224-228 °C
- Boiling point:
- 335.48°C (rough estimate)
- Density
- 1.3764 (rough estimate)
- refractive index
- 1.6180 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Water (Slightly, Heated, Sonicated)
- form
- Pink to brown powder.
- pka
- 2.06±0.10(Predicted)
- color
- White to Off-White
- Merck
- 13,6221
- InChIKey
- WZNJWVWKTVETCG-YFKPBYRVSA-N
- LogP
- -1.080 (est)
- CAS DataBase Reference
- 500-44-7(CAS DataBase Reference)
- EPA Substance Registry System
- Mimosine (500-44-7)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22
- Safety Statements
- 22-36
- WGK Germany
- 3
- HS Code
- 29333990
- Hazardous Substances Data
- 500-44-7(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- M0253
- Product name
- L-Mimosine from Koa hoale seeds
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $33.3
- Updated
- 2024/03/01
- Product number
- M0253
- Product name
- L-Mimosine from Koa hoale seeds
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $427
- Updated
- 2024/03/01
- Product number
- 14337
- Product name
- L-Mimosine
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $25
- Updated
- 2024/03/01
- Product number
- 14337
- Product name
- L-Mimosine
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $38
- Updated
- 2024/03/01
- Product number
- M0253
- Product name
- L-Mimosine from Koa hoale seeds
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $85.4
- Updated
- 2024/03/01
L-MIMOSINE Chemical Properties,Usage,Production
Description
This alkaloid was isolated by Renz from Mimosia pudica L. and also from Leucaena glauca Benth. It is laevorotatory with [α]22D - 21 ° (H20) and yields a blue, crystalline copper salt. On heating the chloride under pressure, a sublimate is formed which has been shown, by comparison with a synthetic specimen, to be N-methyl-3-hydroxypyrid-4-one, m.p. 224°C. The alkaloid is toxic and in horses produces loss of hair when administered in large doses.
Chemical Properties
light tan to pink crystalline powder
Uses
L-Mimosine from Koa hoale seeds has been used to study its anti-inflammatory effect in chronic inflammatory response (potassium permanganate - induced chronic granuloma).
Definition
ChEBI: An L-alpha-amino acid that is propionic acid substituted by an amino group at position 2 and a 3-hydroxy-4-oxopyridin-1(4H)-yl group at position 3 (the 2S-stereoisomer). It a non-protein plant amino acid isolated from Mimosa pudica.
General Description
L-mimosine [β-N (3-hydroxy-4-pyridone)-α-amino propionic acid] is a non-protein amino acid and is a vital component of tropical legumes, such as Leucaena glauca and other legumes belonging to Mimosa spp. Structurally L-mimosine resembles dihydroxyphenylalanine except 3,4-dihydroxy-phenyl ring replaced by 3-hydroxy-4-pyridone ring.
Biochem/physiol Actions
L-Mimosine is a plant amino acid and potential inhibitor of the cell cycle giving rise to growth arrest in G1-phase. It is an iron chelator that inhibits DNA replication in mammalian cells. L-Mimosine has been shown to promote apoptosis in xenotransplanted human pancreatic cancer. L-Mimosine stabilizes hypoxia inducible factor 1 (HIF-1) and stimulates the expression of B-cell translocation gene 2 (Btg2) and N-myc downstream regulated gene 1 (Ndrg1) at the transcriptional level, which reduce cell proliferation of prostate carcinoma cells in vitro. L-Mimosine stabilizes HIF-1 through the inhibition of prolyl hydroxylases (PHDs) which target HIF-1 through degradation. The mechanism of inhibition is likely through the chelation of Fe2+ bound to the active site of PHD which is required for enzymatic activity. Mimosine inhibits cell cycle progression via iron chelation in MDA-MB-453 human breast cancer cells. Mimosine, hinder folate metabolism in cell-specific manner.
References
Renz., Zeit. physiol. Chem., 244, 153 (1936)
Nienburg, Taubock., ibid, 250,80 (1937)
Kostermanns., Rec. trav. Chim. Pays-Bas, 65, 319 (1946)
Kostermann., ibid, 66,93 (1947)
L-MIMOSINE Preparation Products And Raw materials
Raw materials
Preparation Products
L-MIMOSINE Suppliers
- Tel
- --
- Fax
- --
- reag-info@gms.kanto.co.jp
- Country
- Japan
- ProdList
- 6756
- Advantage
- 74
- Tel
- --
- Fax
- --
- labchem-tec@wako-chem.co.jp
- Country
- Japan
- ProdList
- 6819
- Advantage
- 80
View Lastest Price from L-MIMOSINE manufacturers
- Product
- L-MIMOSINE 500-44-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-22
- Product
- L-MIMOSINE 500-44-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- L-MIMOSINE 500-44-7
- Price
- US $1.00/kg
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-12-24