Amsacrine
- Product Name
- Amsacrine
- CAS No.
- 51264-14-3
- Chemical Name
- Amsacrine
- Synonyms
- AMSA;CI-880;m-AMSA;C01553;Amekrin;Amsidyl;Amsakrin;AMSIDINE;Lamasine;SN 11841
- CBNumber
- CB1236394
- Molecular Formula
- C21H19N3O3S
- Formula Weight
- 393.46
- MOL File
- 51264-14-3.mol
Amsacrine Property
- Melting point:
- 230-240 °C
- Boiling point:
- 563.0±60.0 °C(Predicted)
- Density
- 1.2205 (rough estimate)
- refractive index
- 1.6740 (estimate)
- storage temp.
- 2-8°C(protect from light)
- solubility
- Soluble in DMSO
- form
- Powder
- pka
- 8.55±0.10(Predicted)
- CAS DataBase Reference
- 51264-14-3
- IARC
- 2B (Vol. 76) 2000
Safety
- RIDADR
- 3249
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Hazardous Substances Data
- 51264-14-3(Hazardous Substances Data)
- Toxicity
- LD50 in male, female CDF1 mice: 810 mg/m2; 729 mg/m2 orally (Pavkov)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
N-Bromosuccinimide Price
- Product number
- A898095
- Product name
- Amsacrine
- Packaging
- 50mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- CS-1942
- Product name
- Amsacrine
- Purity
- 99.98%
- Packaging
- 100mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- B1302
- Product name
- Amsacrine
- Packaging
- 25mg
- Price
- $156
- Updated
- 2021/12/16
- Product number
- B1302
- Product name
- Amsacrine
- Packaging
- 50mg
- Price
- $179
- Updated
- 2021/12/16
- Product number
- CS-1942
- Product name
- Amsacrine
- Purity
- 99.98%
- Packaging
- 500mg
- Price
- $220
- Updated
- 2021/12/16
Amsacrine Chemical Properties,Usage,Production
Description
Amsacrine is a cytostatic reported to be active against adult lymphoblastic leukemia which has failed primary treatment or become resistant. Its clinical use, however, is associated with significant neuro-, gastro- and hepatotoxicity.
Originator
Auckland Cancer Chemotherapy Lab (New Zealand)
Uses
Amsacrine (Amsidyl) is used as an Investigational drug.
Uses
Amsacrine is a drug undergoing intensive trials for severe leukemia and lymphoma. It is a cytotoxic drug that binds with DNA with expressed specificity to the adenosine–tyrosine pair, thus inhibiting DNA synthesis. It has been suggested to be used for severe leukemia. A synonym of this drug is amsidyl.
Uses
Antineoplastic.
Definition
ChEBI: A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
brand name
Amsidyl (Parke-Davis);Amsakrin.
Synthesis
Amsacrine, 4-(9-acridinylamino)-3-methoxyphenyl-N-methansulfonamide (30.6.11), is made by sulfonating 4-nitro-m-anisidine with methanesulfonyl chloride, which forms a sulfonyl amide 30.6.9, and the nitro group is reduced to an amino group by hydrogen, forming 4-amino-3-methoxyphenyl-N-methansulfonamide (30.6.10). Reacting this with 9-chloroacridine gives amsacrine (30.6.11).
References
[1] nelson em, tewey km, liu lf. mechanism of antitumor drug action: poisoning of mammalian dna topoisomerase ii on dna by 4'-(9-acridinylamino)-methanesulfon-m-anisidide. proc natl acad sci u s a. 1984 mar;81(5):1361-5.
Amsacrine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Amsacrine manufacturers
- Product
- Amsacrine 51264-14-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-01
- Product
- Amsacrine 51264-14-3
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 800 tons
- Release date
- 2020-04-29
- Product
- Amsacrine 51264-14-3
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20 tons
- Release date
- 2020-01-09