Scillascillin
- Product Name
- Scillascillin
- CAS No.
- 52706-07-7
- Chemical Name
- Scillascillin
- Synonyms
- Scylin;Scillascillin;(R)-5,7-Dihydroxyspiro[2H-1-benzopyran-3(4H),5'(6'H)-cyclobuta[f][1,3]benzodioxol]-4-one;Spiro[2H-1-benzopyran-3(4H),5'(6'H)-cyclobuta[f][1,3]benzodioxol]-4-one, 5,7-dihydroxy-, (3R)-
- CBNumber
- CB12418178
- Molecular Formula
- C17H12O6
- Formula Weight
- 312.27
- MOL File
- 52706-07-7.mol
Scillascillin Property
- Boiling point:
- 607.3±55.0 °C(Predicted)
- Density
- 1.69 g/cm3
- pka
- 7.11±0.20(Predicted)
N-Bromosuccinimide Price
- Product number
- CFN98869
- Product name
- Scillascillin
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $513
- Updated
- 2021/12/16
- Product number
- CD32001088
- Product name
- Scillascillin
- Purity
- 95+%
- Packaging
- 5mg
- Price
- $810
- Updated
- 2021/12/16
Scillascillin Chemical Properties,Usage,Production
Uses
Scillascillin (compound 10) is a homoisoflavanone. Scillascillin can be isolated from S. scilloides. Scillascillin shows anticancer activity towards MCF-7 (breast cancer) and DU-145 (prostate cancer) cells with the IC50 of 9.59 and 11.32 ug/ml, respectively[1][2].
Synthesis
The dried whole herb powder of Mianzhaoer was extracted with 95% industrial ethanol for three times at room temperature for 3 d each time, and about 1,936 g of extract was obtained, which was separated by silica gel column chromatography, and 10 fragments were obtained by petroleum ether-acetone elution (Fr. 1-10), and Fr. 3 (petroleum ether-acetone 90??10) was repeatedly combined with Sephadex LH-20 (chloroform-methanol 1??1) to obtain compound 1 (323 mg), 3 (45 mg), 4 (12 mg), which was white powder. Sephadex LH-20 (chloroform-methanol 1:1) to obtain compounds 1 (323 mg), 3 (45 mg), 4 (12 mg); Compound 1: white powder, NMR data and literature reports are consistent, so the identification of Compound 1 is Mianzhaoeruin.
References
[1] Yoichiro Nishida, et al. A new homostilbene and two new homoisoflavones from the bulbs of Scilla scilloides. Chem Pharm Bull (Tokyo). 56, 7. DOI:10.1248/cpb.56.1022
[2] Chinthala Y, et al. Anticancer Active Homoisoflavone from the Underground Bulbs of Ledebouria hyderabadensis. Pharmacognosy Res. 2014;6(4):303-305. DOI:10.4103/0974-8490.138272
Scillascillin Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Scillascillin manufacturers
- Product
- Scillascillin 52706-07-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98% HPLC
- Supply Ability
- 10 tons
- Release date
- 2020-03-12