2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride

Product Name: 2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride
CAS No.: 522-48-5
Chemical Name: 2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride
Synonyms: TETRAHYDROZOLINE HCL;TETRAHYDROZOLINE HYDROCHLORIDE;tyzine;Soothe;Tizine;Visine h;ICI156834;Tinarhinin;ICI 156834;ICI-156834
CBNumber: CB1241978
Molecular Formula: C13H17ClN2
Formula Weight: 236.74
MOL File: 522-48-5.mol

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2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride Property

Melting point:: 248-251°C
storage temp.: Inert atmosphere,Room Temperature
solubility: H2O: freely soluble
form: Solid
color: White to Off-White
InChIKey: BJORNXNYWNIWEY-UHFFFAOYSA-N
CAS DataBase Reference: 522-48-5(CAS DataBase Reference)
EPA Substance Registry System: 1H-Imidazole, 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-, monohydrochloride (522-48-5)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: NJ4550000
HS Code: 2933290000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR1853
Product name: Tetrahydrozoline hydrochloride
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 500mg
Price: $257
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1652001
Product name: Tetrahydrozoline hydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $436
Updated: 2024/03/01

TCI Chemical

Product number: T3148
Product name: Tetrahydrozoline Hydrochloride
Packaging: 5G
Price: $176
Updated: 2024/03/01

TCI Chemical

Product number: T3148
Product name: Tetrahydrozoline Hydrochloride
Packaging: 25G
Price: $573
Updated: 2024/03/01

Cayman Chemical

Product number: 23004
Product name: Tetrahydrozoline (hydrochloride)
Purity: ≥98%
Packaging: 1g
Price: $37
Updated: 2024/03/01

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2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Originator

Tyzine,Pfizer,US,1954

Uses

adrenergic agonist, nasal decongestant

Uses

An alpha agonist, causing constriction of conjunctival blood vessels. Used in over-the-counter eye drops, this compound relieves the redness left by ocular irritants.

Uses

2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride is an alpha agonist, causing constriction of conjunctival blood vessels,it is used in over-the-counter eye drops, this compound relieves the redness left by ocular irritants.

Definition

ChEBI: Tetrahydrozoline hydrochloride is the hydrochloride salt of tetryzoline. It is used as a nasal decongestant. It has a role as a sympathomimetic agent, a vasoconstrictor agent and a nasal decongestant. It contains a tetryzoline(1+).

Manufacturing Process

A mixture of 540 grams (9.0 mols) of ethylenediamine, 270 grams (1.53 mols) of 1,2,3,4tetrahydro-α-naphthoic acid, and 360 ml (4.32 mols) of concentrated hydrochloric acid was introduced into a two-liter, three-necked flask fitted with a thermometer, stirrer, and distillation takeoff. The mixture was distilled under a pressure of about 20 mm of mercury absolute until the temperature rose to 210°C. Thereafter, heating was continued under atmospheric pressure and when the temperature reached about 260°C, an exothermic reaction was initiated. The heat was then adjusted to maintain a reaction temperature of 275° to 280°C for 45 minutes and the mixture thereafter cooled to room temperature.
900 ml of 4 N hydrochloric acid was added and the aqueous layer stirred with warming until a clear, brown solution resulted. This brown solution was made strongly alkaline with sodium hydroxide. The oil that separated solidified and was collected on a filter leaving filtrate A. The solid was dissolved in 370 ml of alcohol with warming, and the solution was treated with 130 ml of concentrated hydrochloric acid with stirring and cooling. This acidified mixture was diluted with 300 ml of ether and chilled. The solid salt was collected and dried and the filtrate concentrated to approximately 300 ml, diluted with 300 ml of ether and the salt which separated collected and dried.
Filtrate A was extracted with ether, dried, acidified with alcoholic hydrogen chloride, and the salt which separated was collected and dried. There was thus obtained, when all the salt had been combined, 250 grams (69.3% of the theoretical yield) of 2-(1,2,3,4-tetrahydro-1-naphthyl)imidazoline hydrochloride, melting at 256° to 257°C.

brand name

Tetryzo- line is INN and BAN; Tetryzoline Hydrochloride is JAN; Tetrahydrozoline Nitrate is JAN.

Therapeutic Function

Nasal decongestant, Pharmaceutic aid

2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride Suppliers

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View Lastest Price from 2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride 522-48-5
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-11-15

Hebei Weibang Biotechnology Co., Ltd

Product: TETRAHYDROZOLINE HYDROCHLORIDE 522-48-5
Price: US $10.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-12-04

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Tetrahydrozoline Hydrochloride 522-48-5
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-10-09

522-48-5, 2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochlorideRelated Search:

Tetrahydrozoline-d4 Hydrochloride Pirenzepine hydrochloride Rimantadine hydrochloride FLUOXETINE HYDROCHLORIDE Robenidine hydrochloride 1-beta-D-Arabinofuranosylcytosine hydrochloride Clorprenaline hydrochloride Moroxydine hydrochloride Flunarizine dihydrochloride Methyl nicotinoylacetate Hydrazine monohydrochloride Bromhexine hydrochloride Dexmedetomidine hydrochloride Alizapride hydrochloride Benserazide hydrochloride STACHYDRINE HYDROCHLORIDE Benzamidine hydrochloride hydrate 1-Adamantanamine hydrochloride

2-(1,2,3,4-Tetrahydro-1-Naphthylamino)-2-ImidazolineHydrochloride

Tetrahydrozline

TETRAHYDROZOLINEHYDROCHLORIDE,USP

2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride

2-(1,2,3,4-Tetrahydronaphthalene-1-yl)-4,5-dihydro-1H-imidazole·hydrochloride

Tetrahydrozoline hyrdrochloride

Tetrahydrozoline·hydrochloric acid

Tetrahydrozoline Hydrochloride (200 mg)

4,5-Dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-iMidazole Hydrochloride

Murine Plus

Soothe

Tinarhinin

Tizine

Visine h

Tetrehydrozoline

2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-iMidazole hydrochloride

TETRAHYDROZOLINE HCL

TETRAHYDROZOLINE HYDROCHLORIDE

2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazolinehydrochloride

2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazolinemonohydrochloride

2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazolinhydrochloride

4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-1h-imidazolmonohydroch

4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-1h-imidazolmonohydrochlo

dl-2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazolinehydrochloride

dl-tetrahydrozolinehydrochloride

tetryzolinehydrochloride

tyzanolhydrochloride

tyzine

tyzinehydrochloride

visinehydrochloride

2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazole

4,5-Dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-imidazole monohydrochloride

1H-Imidazole, 4,5-dihydro-2-(1,2,3,4-t

2-(1-tetralinyl)-4,5-dihydro-1H-imidazole

2-(1-tetralinyl)-4,5-dihydro-1H-imidazole hydrochloride

2-tetralin-1-yl-4,5-dihydro-1H-imidazole

Collyrium Fresh-Eye Drops

Tetrahydrozoline hydrochloride (JAN/USP)

Tyzine (TN)

Tetrahydrozoline hydrochloride, 98%, a α-adrenoceptor agonist

Tetryzoline hydrochloride CRS

Tetryzoline HCl

2-[(1RS)-1,2,3,4-Tetrahydronaphthalen-1-yl]-4,5-dihydro-1H-imidazole hydrochloride

2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride USP/EP/BP

TETRAHYDROZOLINE HCL， TETRAHYDROZOLINE HYDROCHLORIDE

Tetrahydrozoline HCl (Tetryzoline)

Tetrahydrozoline Hydrochloride (1652001)

ICI 156834

ICI156834

ICI-156834

522-48-5

VISINE

Intermediates & Fine Chemicals

Pharmaceuticals

Adrenergics

Agonists

Neurotransmitters

Pharmaceutical intermediates