2,5-Dichloro-4-iodopyridine
- Product Name
- 2,5-Dichloro-4-iodopyridine
- CAS No.
- 796851-03-1
- Chemical Name
- 2,5-Dichloro-4-iodopyridine
- Synonyms
- 2,5-Dichloro-4-iodopyridine;Pyridine, 2,5-dichloro-4-iodo-;2,5-Dichloro-4-iodopyridine 98%;Pyridine, 2,5-dichloro-4-iodo- ISO 9001：2015 REACH
- CBNumber
- CB12456686
- Molecular Formula
- C5H2Cl2IN
- Formula Weight
- 273.89
- MOL File
- 796851-03-1.mol
2,5-Dichloro-4-iodopyridine Property
- Melting point:
- 140 ºC
- Boiling point:
- 279 ºC
- Density
- 2.129
- Flash point:
- 122 ºC
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- pka
- -2.42±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- D434888
- Product name
- 2,5-Dichloro-4-iodopyridine
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- OR345414
- Product name
- 2,5-Dichloro-4-iodopyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $138
- Updated
- 2021/12/16
- Product number
- 114070
- Product name
- 2,5-Dichloro-4-iodopyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $148
- Updated
- 2021/12/16
- Product number
- FC151283
- Product name
- 4-Chloro-2-fluoro-5-iodopyridine
- Packaging
- 2g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 3H32-M-30
- Product name
- 2,5-Dichloro-4-iodopyridine
- Packaging
- 5G
- Price
- $152
- Updated
- 2021/12/16
2,5-Dichloro-4-iodopyridine Chemical Properties,Usage,Production
Synthesis
16110-09-1
796851-03-1
a) Dissolve 2,5-dichloropyridine (10 g, 67.57 mmol) in THF (17 mL) under nitrogen protection and slowly add dropwise to a mixture of n-BuLi isohexane solution (33.8 mL, 67.57 mmol) and diisopropylamine (9.63 mL, 67.57 mmol) in THF (68.0 mL) that has been pre-cooled to -78°C. . After the dropwise addition, the reaction mixture was continued to be stirred at -78°C for 30 min. Subsequently, a solution of THF (17.0 mL) with I2 (17.49 g, 68.92 mmol) was added slowly dropwise, and after completion of the dropwise addition, the reaction was kept at -78°C for 1 hour. At the end of the reaction, the reaction was quenched with deionized water (75 mL) and slowly warmed to room temperature. The reaction mixture was extracted with ether (3 x 100 mL), the organic phases were combined, dried with anhydrous MgSO4 and concentrated under reduced pressure. The residue was ground with dichloromethane to give the solid product 2,5-dichloro-4-iodopyridine (9.72 g, 53% yield). The concentrated residue of the filtrate was purified by silica gel column chromatography using a gradient elution with a 50-100% isohexane solution of dichloromethane. The product-containing fraction was collected, concentrated under reduced pressure, and the residue was ground with methanol to give a second batch of 2,5-dichloro-4-iodopyridine (5.74 g, 31% yield).1H NMR (300 MHz, DMSO) δ 7.85 (1H, s), 8.34 (1H, s).
References
[1] Tetrahedron Letters, 2004, vol. 45, # 42, p. 7873 - 7877
[2] Patent: WO2009/153589, 2009, A1. Location in patent: Page/Page column 117
[3] Patent: WO2009/66786, 2009, A1. Location in patent: Page/Page column 120
[4] Patent: US2017/29404, 2017, A1. Location in patent: Paragraph 0267-0269
[5] ACS Chemical Neuroscience, 2017, vol. 8, # 9, p. 1980 - 1994
2,5-Dichloro-4-iodopyridine Preparation Products And Raw materials
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View Lastest Price from 2,5-Dichloro-4-iodopyridine manufacturers
- Product
- 4-Chloro-2-fluoro-5-iodopyridine 796851-03-1
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-31
- Product
- Pyridine, 2,5-dichloro-4-iodo- 796851-03-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-01
- Product
- Pyridine, 2,5-dichloro-4-iodo 796851-03-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 200KG
- Release date
- 2018-08-19