2,4-Dichloropyridine-3-carboxylic acid
- Product Name
- 2,4-Dichloropyridine-3-carboxylic acid
- CAS No.
- 262423-77-8
- Chemical Name
- 2,4-Dichloropyridine-3-carboxylic acid
- Synonyms
- 2,4-Dichloronicotinic acid;2,4-Dichloronicotinc Acid;2,4-DichloronicotinicAcid>2,4-DICHLORONICOTINIC ACID,98%;2,4- twochlorine nicotinic acid;2,4-Dichloropyridine-3-carboxylicaci;2,4-Dichloropyridine-3-carboxylic acid;3-Pyridinecarboxylic acid, 2,4-dichloro-;262423-77-8;2,4-Dichloropyridine-3-carboxylic acid, CAS 262423-77-8
- CBNumber
- CB91459491
- Molecular Formula
- C6H3Cl2NO2
- Formula Weight
- 192
- MOL File
- 262423-77-8.mol
2,4-Dichloropyridine-3-carboxylic acid Property
- Melting point:
- 166-167°
- Boiling point:
- 325.2±37.0 °C(Predicted)
- Density
- 1.612±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 0.79±0.25(Predicted)
- color
- White to Almost white
- InChI
- InChI=1S/C6H3Cl2NO2/c7-3-1-2-9-5(8)4(3)6(10)11/h1-2H,(H,10,11)
- InChIKey
- ZFGZNVSNOJPGDV-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC(Cl)=C1C(O)=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 710830
- Product name
- 2,4-Dichloropyridine-3-carboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $25
- Updated
- 2023/01/07
- Product number
- D4901
- Product name
- 2,4-Dichloronicotinic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $33
- Updated
- 2025/07/31
- Product number
- D4901
- Product name
- 2,4-Dichloronicotinic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $95
- Updated
- 2025/07/31
- Product number
- D437153
- Product name
- 2,4-Dichloropyridine-3-carboxylic acid
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FD142970
- Product name
- 2,4-Dichloronicotinic acid
- Packaging
- 25g
- Price
- $360
- Updated
- 2021/12/16
2,4-Dichloropyridine-3-carboxylic acid Chemical Properties,Usage,Production
Chemical Properties
off-white powder
Uses
2,4-Dichloropyridine-3-carboxylic Acid is useful for the preparation of prolyl hydroxylase inhibitors or erythropoietin inducing agents.
Synthesis
26452-80-2
124-38-9
262423-77-8
GENERAL STEPS: A THF solution (28.4 mL, 56.8 mmol) of 2M lithium diisopropylammonium (LDA) was slowly added to a tetrahydrofuran (THF, 70 mL) solution of 2,4-dichloropyridine (7 g, 47.3 mmol) at -78 °C, maintaining the temperature at -78 °C and stirring for 30 min. Upon completion of the reaction, the reaction mixture was quenched with excess dry ice, followed by warming to room temperature and continued stirring for 30 min. After neutralizing the reaction mixture with 1.5 N hydrochloric acid (HCl), it was diluted with ethyl acetate (100 mL) and washed sequentially with saturated brine (2 x 50 mL) and deionized water (100 mL). The organic layer was separated, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to afford 2,4-dichloronicotinic acid (4.5 g, 23.44 mmol, 50% yield) as a brown solid. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 8.47 (d, 1H), 7.74 (d, 1H).
References
[1] Patent: WO2016/149393, 2016, A1. Location in patent: Paragraph 0426
[2] Patent: US2011/77267, 2011, A1. Location in patent: Page/Page column 27
[3] European Journal of Organic Chemistry, 2001, # 7, p. 1371 - 1376
[4] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 1, p. 386 - 390
[5] Patent: WO2015/116060, 2015, A1. Location in patent: Page/Page column 92
2,4-Dichloropyridine-3-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-Dichloropyridine-3-carboxylic acid manufacturers
- Product
- 2,4-Dichloropyridine-3-carboxylic acid 262423-77-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-14
- Product
- 2,4-Dichloronicotinic acid 262423-77-8
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- 98%
- Supply Ability
- Inquiry
- Release date
- 2023-07-13
- Product
- 2,4-Dichloropyridine-3-carboxylic acid 262423-77-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-26