2,3-Dichloropyridine-4-carboxaldehyde
- Product Name
- 2,3-Dichloropyridine-4-carboxaldehyde
- CAS No.
- 884495-41-4
- Chemical Name
- 2,3-Dichloropyridine-4-carboxaldehyde
- Synonyms
- 2,3-dichloroisonicotinaldehyde;2,3-dichloropyridine-4-carbaldehyde;2,3-Dichloropyridine-4-carboxaldehyde;2,3-Dichloro-4-pyridinecarboxaldehyde;4-Pyridinecarboxaldehyde, 2,3-dichloro-;2,3-dichloro-5-forMylpyridine-4-carboxylic acid;2,3-Dichloropyridine-4-carboxaldehyde ISO 9001：2015 REACH;2,3-Dichloropyridine-2,3-Dichloropyridine-4-carboxaldehyde4-carboxaldehyde
- CBNumber
- CB9967298
- Molecular Formula
- C6H3Cl2NO
- Formula Weight
- 176
- MOL File
- 884495-41-4.mol
2,3-Dichloropyridine-4-carboxaldehyde Property
- Melting point:
- 94-96°
- Boiling point:
- 262℃
- Density
- 1.488
- Flash point:
- 112℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -2.00±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D476038
- Product name
- 2,3-Dichloroisonicotinaldehyde
- Packaging
- 250mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- D15686
- Product name
- 2,3-Dichloroisonicotinaldehyde
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 046922
- Product name
- 2,3-Dichloroisonicotinaldehyde
- Purity
- >95%
- Packaging
- 500mg
- Price
- $163
- Updated
- 2021/12/16
- Product number
- 4H15-5-83
- Product name
- 2,3-Dichloroisonicotinaldehyde
- Packaging
- 500mg
- Price
- $202
- Updated
- 2021/12/16
- Product number
- D15686
- Product name
- 2,3-Dichloroisonicotinaldehyde
- Packaging
- 5g
- Price
- $230
- Updated
- 2021/12/16
2,3-Dichloropyridine-4-carboxaldehyde Chemical Properties,Usage,Production
Uses
2,3-Dichloroisonicotinaldehyde is used in preparation of spiroaminoindene piperidines as Shp2 phosphatase inhibitors for treatment of disorders associated with SHP2 deregulation.
Synthesis
2402-77-9
68-12-2
884495-41-4
General procedure: 2,3-dichloropyridine (10 g, 67.57 mmol) was dissolved in dry tetrahydrofuran (200 ml) under nitrogen protection and cooled to -78 °C. A hexane solution of n-butyllithium (37.165 ml, 74 mmol, 2M) was added slowly and dropwise. The reaction mixture was stirred at -78°C for 20 min and then dry N,N-dimethylformamide (6.28 ml, 81.087 mmol) was added dropwise. Stirring was continued at -78 °C for 15 min, followed by slow warming of the reaction mixture to room temperature. Upon completion of the reaction, the reaction was quenched with water and extracted with dichloromethane. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was initially purified by fast column chromatography (dichloromethane as eluent). The fraction containing 2,3-dichloropyridine-4-carbaldehyde was collected and concentrated under reduced pressure to give the crude product. It was further purified by column chromatography (silica gel; dichloromethane/heptane as eluent, gradient elution to 50%). The target fraction was collected and concentrated under reduced pressure to afford the intermediate compound D41 (4.15 g, 34.9% yield) as a white solid.GC-MS retention time (min): 7.9.
References
[1] Patent: WO2009/62676, 2009, A2. Location in patent: Page/Page column 65
[2] Patent: WO2010/130424, 2010, A1. Location in patent: Page/Page column 109-110
[3] Patent: US2010/298334, 2010, A1. Location in patent: Page/Page column 57
2,3-Dichloropyridine-4-carboxaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,3-Dichloropyridine-4-carboxaldehyde manufacturers
- Product
- 2,3-Dichloropyridine-4-carboxaldehyde 884495-41-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-14
- Product
- 2,3-Dichloropyridine-4-carboxaldehyde 884495-41-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-03
- Product
- 2,3-Dichloropyridine-4-carboxaldehyde 884495-41-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%-100%
- Supply Ability
- 1
- Release date
- 2018-08-12