ChemicalBook > CAS DataBase List > 2,3-Dichloropyridine-4-carboxaldehyde

2,3-Dichloropyridine-4-carboxaldehyde

Product Name: 2,3-Dichloropyridine-4-carboxaldehyde
CAS No.: 884495-41-4
Chemical Name: 2,3-Dichloropyridine-4-carboxaldehyde
Synonyms: 2,3-dichloroisonicotinaldehyde;2,3-dichloropyridine-4-carbaldehyde;2,3-Dichloropyridine-4-carboxaldehyde;2,3-Dichloro-4-pyridinecarboxaldehyde;4-Pyridinecarboxaldehyde, 2,3-dichloro-;2,3-dichloro-5-forMylpyridine-4-carboxylic acid;2,3-Dichloropyridine-4-carboxaldehyde ISO 9001：2015 REACH;2,3-Dichloropyridine-2,3-Dichloropyridine-4-carboxaldehyde4-carboxaldehyde
CBNumber: CB9967298
Molecular Formula: C6H3Cl2NO
Formula Weight: 176
MOL File: 884495-41-4.mol

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2,3-Dichloropyridine-4-carboxaldehyde Property

Melting point:: 94-96°
Boiling point:: 262℃
Density: 1.488
Flash point:: 112℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -2.00±0.10(Predicted)
Appearance: White to off-white Solid

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Safety

HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: D476038
Product name: 2,3-Dichloroisonicotinaldehyde
Packaging: 250mg
Price: $60
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: D15686
Product name: 2,3-Dichloroisonicotinaldehyde
Packaging: 1g
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 046922
Product name: 2,3-Dichloroisonicotinaldehyde
Purity: >95%
Packaging: 500mg
Price: $163
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H15-5-83
Product name: 2,3-Dichloroisonicotinaldehyde
Packaging: 500mg
Price: $202
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: D15686
Product name: 2,3-Dichloroisonicotinaldehyde
Packaging: 5g
Price: $230
Updated: 2021/12/16

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2,3-Dichloropyridine-4-carboxaldehyde Chemical Properties,Usage,Production

Uses

2,3-Dichloroisonicotinaldehyde is used in preparation of spiroaminoindene piperidines as Shp2 phosphatase inhibitors for treatment of disorders associated with SHP2 deregulation.

Synthesis

2402-77-9

68-12-2

884495-41-4

General procedure: 2,3-dichloropyridine (10 g, 67.57 mmol) was dissolved in dry tetrahydrofuran (200 ml) under nitrogen protection and cooled to -78 °C. A hexane solution of n-butyllithium (37.165 ml, 74 mmol, 2M) was added slowly and dropwise. The reaction mixture was stirred at -78°C for 20 min and then dry N,N-dimethylformamide (6.28 ml, 81.087 mmol) was added dropwise. Stirring was continued at -78 °C for 15 min, followed by slow warming of the reaction mixture to room temperature. Upon completion of the reaction, the reaction was quenched with water and extracted with dichloromethane. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was initially purified by fast column chromatography (dichloromethane as eluent). The fraction containing 2,3-dichloropyridine-4-carbaldehyde was collected and concentrated under reduced pressure to give the crude product. It was further purified by column chromatography (silica gel; dichloromethane/heptane as eluent, gradient elution to 50%). The target fraction was collected and concentrated under reduced pressure to afford the intermediate compound D41 (4.15 g, 34.9% yield) as a white solid.GC-MS retention time (min): 7.9.

References

[1] Patent: WO2009/62676, 2009, A2. Location in patent: Page/Page column 65
[2] Patent: WO2010/130424, 2010, A1. Location in patent: Page/Page column 109-110
[3] Patent: US2010/298334, 2010, A1. Location in patent: Page/Page column 57

2,3-Dichloropyridine-4-carboxaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,3-Dichloropyridine-4-carboxaldehyde manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2,3-Dichloropyridine-4-carboxaldehyde 884495-41-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-14

Dideu Industries Group Limited

Product: 2,3-Dichloropyridine-4-carboxaldehyde 884495-41-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-03

Career Henan Chemical Co

Product: 2,3-Dichloropyridine-4-carboxaldehyde 884495-41-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%-100%
Supply Ability: 1
Release date: 2018-08-12

884495-41-4, 2,3-Dichloropyridine-4-carboxaldehydeRelated Search:

2,3,5,6-TETRACHLOROPYRIDINE-4-CARBOXALDEHYDE 2,3,5-Trichloropyridine-4-carboxaldehyde 3,5-Dichloropyridine-4-carboxaldehyde,,5-Dichloropyridine-4-carboxaldehyde 2,3-Dichloropyridine-4-carboxaldehyde 2,5-DICHLOROPYRIDINE-4-CARBOXALDEHYDE 2,4-DICHLOROPYRIDINE-3-CARBOXALDEHYDE 5,6-Dichloropyridine-3-carboxaldehyde 2-Pyridinecarboxaldehyde, 3,6-dichloro- 2,3-DICHLOROPYRIDINE-4-CARBOXYLIC ACID 2,6-Dichloropyridine-4-carboxaldehyde ,98%,2,6-DICHLOROPYRIDINE-4-CARBOXALDEHYDE 2,3-Dichloropyridine 2,3-Dichloro-N-methyl-4-pyridinecarboxamide 2,3,5-Trichloropyridine-4-carboxylic acid 2,3,5,6-Tetrachloropyridine-4-carboxylic acid METHYL 2,3-DICHLOROISONICOTINATE 2,3,5,6-TETRACHLOROISONICOTINOYL CHLORIDE ETHYL 2,3,5-TRICHLORO-6-{[(DIMETHYLAMINO)CARBONOTHIOYL]THIO}ISONICOTINATE N'-(2,6-DICHLOROISONICOTINOYL)-2,6-DICHLOROPYRIDINE-4-CARBOXALDEHYDE HYDRAZONE, TECH

2,3-Dichloropyridine-4-carboxaldehyde

2,3-dichloroisonicotinaldehyde

2,3-Dichloro-4-pyridinecarboxaldehyde

2,3-dichloro-5-forMylpyridine-4-carboxylic acid

2,3-dichloropyridine-4-carbaldehyde

2,3-Dichloropyridine-2,3-Dichloropyridine-4-carboxaldehyde4-carboxaldehyde

4-Pyridinecarboxaldehyde, 2,3-dichloro-

2,3-Dichloropyridine-4-carboxaldehyde ISO 9001：2015 REACH

884495-41-4

Pyridines

Pyridine

intermediate