2,4-Dichloropyridine-3-carboxaldehyde
Application- Product Name
- 2,4-Dichloropyridine-3-carboxaldehyde
- CAS No.
- 134031-24-6
- Chemical Name
- 2,4-Dichloropyridine-3-carboxaldehyde
- Synonyms
- 2,4-dichloronicotinaldehyde;EOS-61543;2,4-Dichloro-3-formylpyridine;2,4-dichloronicotinaldehyde (en);2,4-Dichloro-pyridin-3-carbaldehyde;2,4-DICHLOROPYRIDINE-3-CARBOXALDEHYDE;3-Pyridinecarboxaldehyde,2,4-dichloro;2,4-dichloro-3-pyridine Carboxaldehyde;2,4-Dichloropyridine-3-carboxaldehyde 97%;2,4-Dichloropyridine-3-carboxaldehyde, CAS 134031-24-6
- CBNumber
- CB4132686
- Molecular Formula
- C6H3Cl2NO
- Formula Weight
- 176
- MOL File
- 134031-24-6.mol
2,4-Dichloropyridine-3-carboxaldehyde Property
- Melting point:
- 72-75℃
- Boiling point:
- 261.8±35.0 °C(Predicted)
- Density
- 1.488±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- powder to crystal
- pka
- -1.17±0.10(Predicted)
- color
- White to Orange to Green
- Sensitive
- Air Sensitive
- InChI
- InChI=1S/C6H3Cl2NO/c7-5-1-2-9-6(8)4(5)3-10/h1-3H
- InChIKey
- GWBHJHIZHNTJLA-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC(Cl)=C1C=O
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26
- RIDADR
- UN 2811 6.1 / PGIII
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 711365
- Product name
- 2,4-Dichloropyridine-3-carboxaldehyde
- Purity
- 97%
- Packaging
- 500mg
- Price
- $97.2
- Updated
- 2023/01/07
- Product number
- D5076
- Product name
- 2,4-Dichloro-3-pyridinecarboxaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $47
- Updated
- 2025/07/31
- Product number
- D5076
- Product name
- 2,4-Dichloro-3-pyridinecarboxaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $228
- Updated
- 2025/07/31
- Product number
- D438468
- Product name
- 2,4-Dichloronicotinaldehyde
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- Y14235
- Product name
- 2,4-Dichloropyridine-3-carboxaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $30
- Updated
- 2021/12/16
2,4-Dichloropyridine-3-carboxaldehyde Chemical Properties,Usage,Production
Application
2,4-Dichloronicotinaldehyde, also known as 2,4-dichloronicotinaldehyde, can be obtained by reacting 2,4-dichloropyridine with a strong base to obtain (2,4-4-dichloro-3-pyridyl)lithium, and then reacting it with DMF.
Chemical Properties
Yellow solid
Synthesis
To a solution of 2,4-dichloropyridine (2 g, 13.51 mmol) in tetrahydrofuran (20 mL) at -78° C added LDA in THF/heptane/ethylbenzene (2M, 8.11 mL, 16.22 mmol) and the solution was stirred for 30 min. DMF (10.46 mL, 135 mmol) was added and the solution was stirred for 1 h and then warmed RT. The reaction mixture was quenched with saturated NH4Cl solution and diluted with ethyl acetate (50 mL). The organic layer was washed with saturated NaHCO3 (2*10 mL), water (20 mL), dried over Na2SO4, and concentrated under reduced pressure to afford 2,4-dichloronicotinaldehyde (2 g, 11.36 mmol, 84% yield).
References
[1] Tetrahedron Letters, 2011, vol. 52, # 4, p. 523 - 525
[2] Organic Process Research and Development, 2018, vol. 22, # 8, p. 978 - 990
[3] Patent: US2013/237555, 2013, A1. Location in patent: Paragraph 0273
[4] Patent: WO2015/38112, 2015, A1. Location in patent: Page/Page column 126
[5] Patent: WO2018/109050, 2018, A1. Location in patent: Paragraph 0286-0297
2,4-Dichloropyridine-3-carboxaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-Dichloropyridine-3-carboxaldehyde manufacturers
- Product
- 2,4-Dichloropyridine-3-carboxaldehyde 134031-24-6
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- 98%
- Supply Ability
- Inquiry
- Release date
- 2023-07-11
- Product
- 2,4-Dichloro-3-pyridine carboxaldehyde 134031-24-6
- Price
- US $200.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10Tons
- Release date
- 2021-07-20
- Product
- 2,4-Dichloropyridine-3-carboxaldehyde 134031-24-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-26