AMG-706
- Product Name
- AMG-706
- CAS No.
- 857876-30-3
- Chemical Name
- AMG-706
- Synonyms
- CS-459;AMG-706;Unii-T6Q3060U91;Diphosphate salt;AMG-706 USP/EP/BP;Motesanib(AMG-706);Motesanib phosphate;Motesanib diphosphate;AMG706; AMG 706; AMG-706;Motesanib, Diphosphate Salt
- CBNumber
- CB12473858
- Molecular Formula
- C22H29N5O9P2
- Formula Weight
- 569.441282
- MOL File
- 857876-30-3.mol
AMG-706 Property
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- ≥28.45 mg/mL in DMSO; insoluble in H2O; ≥3.47 mg/mL in EtOH with ultrasonic
- form
- Powder
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 17671
- Product name
- AMG 706
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 17671
- Product name
- AMG 706
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $130
- Updated
- 2024/03/01
- Product number
- 17671
- Product name
- AMG 706
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $211
- Updated
- 2024/03/01
- Product number
- 17671
- Product name
- AMG 706
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $660
- Updated
- 2024/03/01
- Product number
- 474141
- Product name
- Motesanib diphosphate
- Packaging
- 100mg
- Price
- $1805
- Updated
- 2021/12/16
AMG-706 Chemical Properties,Usage,Production
Uses
An oral angiogenesis inhibitor, demonstrates clinical efficacy in advanced thymoma.
Uses
Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3, PDGFR, c-Kit and Ret with IC50 of 2 nM/3 nM/6 nM, 84 nM, 8 nM and 59 nM, respectively.
Biological Activity
motesanib diphosphate is a diphosphate form of motesanib. it is a potent atp-competitive inhibitor of vegfr1/2/3 with ic50 of 2 nm/3 nm/6 nm, respectively [1].vascular endothelial growth factor (vegf) is an important signaling protein involved in both vasculogenesis (the formation of the circulatory system) and angiogenesis (the growth of blood vessels from pre-existing vasculature). motesanib (amg 706) is an orally administered small molecule belonging to angiokinase inhibitor class which acts as an antagonist of vegf receptors, platelet-derived growth factor receptors, and stem cell factor receptors.
in vitro
motesanib diphosphate has broad activity against the human vegfr family, and displays >1000 selectivity against egfr, src, and p38 kinase. motesanib diphosphate significantly inhibits vegf-induced cellular proliferation of huvecs with an ic50 of 10 nm, while displaying little effect at bfgf-induced proliferation with an ic50 of >3,000 nm. motesanib diphosphate also potently inhibits pdgf-induced proliferation and scf-induced c-kit phosphorylation with ic50 of 207 nm and 37 nm, respectively, but not effective against the egf-induced egfr phosphorylation and cell viability of a431 cells [1]. althouth displaying little antiproliferative activity on cell growth of huvecs alone, motesanib diphosphate treatment significantly sensitizes the cells to fractionated radiation [2].
in vivo
oral administration of amg 706 potently inhibited vegf-induced angiogenesis in the rat corneal model and induced regression of established a431 xenografts. amg 706 was well tolerated and had no significant effects o amg 706n body weight or on the general health of the animals. histologic analysis of tumor xenografts from amg 706–treated animals revealed an increase in endothelial apoptosis and a reduction in blood vessel area that preceded an increase in tumor cell apoptosis. in summary, amg 706 is an orally bioavailable, well-tolerated multikinase inhibitor that is presently under clinical investigation for the treatment of human malignancies [1].
target
VEGFR
AMG-706 Preparation Products And Raw materials
Raw materials
Preparation Products
AMG-706 Suppliers
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View Lastest Price from AMG-706 manufacturers
- Product
- AMG-706 857876-30-3
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-23