ELASTATINAL

Product Name: ELASTATINAL
CAS No.: 51798-45-9
Chemical Name: ELASTATINAL
Synonyms: ELASTATINAL;AIDS-006470;Leu-co-cpd-Gln-Ala-h;ELASTATINAL USP/EP/BP;Elastatinal, elastase inhibitor;elastatinal from microbial source;N-[-N-ALPHA-CARBONYL-CPD-GLN-ALA-AL]-LEU;l-glutamamide,l-2-(2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl-n-(((1-carboxy-3-m;N-[(S)-1-CARBOXYISOPENTYL]CARBAMOYL-ALPHA-[2-IMINOHEXAHYDRO-4(S)-PYRIMIDYL-(S)-GLYCYL-(S)-GLUTAMINYL-(S)-ALANINAL];Nα-[2-(2-Amino-1,4,5,6-tetrahydropyrimidin-4-yl)-N-[[(1-carboxy-3-methylbutyl)amino]carbonyl]-L-glycyl]-N1-(1-methyl-2-oxoethyl)-L-glutaminamide
CBNumber: CB1249000
Molecular Formula: C21H36N8O7
Formula Weight: 512.56
MOL File: 51798-45-9.mol

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ELASTATINAL Property

storage temp.: -20°C
solubility: H₂O: 20 mg/mL, clear, yellow
form: Yellow solid.
color: off-white
biological source: microbial
Water Solubility: water: 20mg/mL, clear, faintly yellow to yellow
BRN: 873543
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
RTECS: LZ9600000
F: 10

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: E0881
Product name: Elastatinal
Purity: microbial
Packaging: 5mg
Price: $130.9
Updated: 2025/07/31

Sigma-Aldrich

Product number: E0881
Product name: Elastatinal
Purity: microbial
Packaging: 10mg
Price: $340
Updated: 2025/07/31

Cayman Chemical

Product number: 22288
Product name: Elastatinal
Purity: ≥95%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 22288
Product name: Elastatinal
Purity: ≥95%
Packaging: 10mg
Price: $176
Updated: 2024/03/01

Sigma-Aldrich

Product number: E0881
Product name: Elastatinal
Purity: microbial
Packaging: 25mg
Price: $631.54
Updated: 2025/07/31

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ELASTATINAL Chemical Properties,Usage,Production

Description

Elastatinal is a potent inhibitor of pancreatic elastase (K_i = 240 nM) that is produced by various species of Actinomycetes. It more strongly inhibits pancreatic elastase versus the leukocyte-derived enzyme. Elastatinal reduces electrophoretic mobilities of 2A proteinases from poliovirus and human rhinovirus 14 in a dose-dependent manner, indicating substrate recognition by 2A proteinases is similar to that of pancreatic elastases. It can also inhibit elastase-like protease collagenolytic protease from C. maenas digestive glands.

Uses

Elastatinal is an elastase inhibitor.

Biochem/physiol Actions

Potent, irreversible elastase inhibitor. Elastatinal is a much stronger inhibitor of elastase from pancreas than from leucocytes.

References

[1] H UMEZAWA. Letter: Elastatinal, a new elastase inhibitor produced by actinomycetes.[J]. Journal of Antibiotics, 1973, 26 12: 787-789. DOI:10.7164/antibiotics.26.787
[2] KAZUYUKI NAKAJIMA. Identification of Elastase as a Secretory Protease from Cultured Rat Microglia[J]. Journal of Neurochemistry, 1992, 58 4: 1401-1408. DOI:10.1111/j.1471-4159.1992.tb11356.x
[3] A MOLLA E W C U Hellen. Inhibition of proteolytic activity of poliovirus and rhinovirus 2A proteinases by elastase-specific inhibitors.[J]. Journal of Virology, 1993, 67 8: 4688-4695. DOI:10.1128/jvi.67.8.4688-4695.1993
[4] L. MENÉNDEZ-ARIAS S O C Risco. Isolation and characterization of alpha 2-macroglobulin-protease complexes from purified mouse mammary tumor virus and culture supernatants from virus-infected cell lines.[J]. The Journal of Biological Chemistry, 1992, 9 1: 11392-11398. DOI:10.1016/s0021-9258(19)49923-7

ELASTATINAL Preparation Products And Raw materials

Raw materials

Preparation Products

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ELASTATINAL Suppliers

China 65 Germany 3 India 1 Japan 2 Switzerland 1 United Kingdom 2 United States 17 Global 91

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Alabiotech Inc.

Tel: 001-619-354-5251
Fax: 001-855-855-6087
Email: sales@alabiotech-e.com
Country: United States
ProdList: 972
Advantage: 60

Alpha Biopharmaceuticals Co., Ltd

Tel: 0411-39042497
Fax: 0411-39042693
Email: sales@alphabiopharm.com
Country: China
ProdList: 1951
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

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View Lastest Price from ELASTATINAL manufacturers

Career Henan Chemical Co

Product: ELASTATINAL 51798-45-9
Price: US $1.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: g/kg/Ton
Release date: 2020-01-08

51798-45-9, ELASTATINALRelated Search:

ACTINONIN P-5091 6-fluoro-N-(4-fluorobenzyl)quinazolin-4-aMine ZPCK Elastatinal (1.24822) ELASTATINAL Dibutylurea

N-[-N-ALPHA-CARBONYL-CPD-GLN-ALA-AL]-LEU

elastatinal from microbial source

L-2-(2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl)-N-[[(1-carboxy-3-methylbutyl)amino]carbonyl]glycyl-N1-(1-methyl-2-oxoethyl)-L-glutamamide, stereoisomer

Leu-co-cpd-Gln-Ala-h

L-Glutamamide, (2S)-2-(4S)-2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl-N-(1S)-1-carboxy-3-methylbutylaminocarbonylglycyl-N1-(1S)-1-methyl-2-oxoethyl-

(2s)-2-[(4s)-2-amino-1,4,5,6-tetrahydro4-pyrimidinyl]-n-[[[(1s)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-n1-[(1s)-1-methyl-2-oxoethyl-l-glutamamide

AIDS-006470

Nα-[2-(2-Amino-1,4,5,6-tetrahydropyrimidin-4-yl)-N-[[(1-carboxy-3-methylbutyl)amino]carbonyl]-L-glycyl]-N1-(1-methyl-2-oxoethyl)-L-glutaminamide

(2S)-2-[(4S)-2-Amino-3,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N1-[(1S)-1-methyl-2-oxoethyl]-L-glutamamide

l-glutamamide,l-2-(2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl-n-(((1-carboxy-3-m

ELASTATINAL

N-[(S)-1-CARBOXYISOPENTYL]CARBAMOYL-ALPHA-[2-IMINOHEXAHYDRO-4(S)-PYRIMIDYL-(S)-GLYCYL-(S)-GLUTAMINYL-(S)-ALANINAL]

L-Glutamamide, (2S)-2-[(4S)-2-amino-3,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N1-[(1S)-1-methyl-2-oxoethyl]-

ELASTATINAL USP/EP/BP

(2S)-2-[[(1S)-2-[[(2S)-5-amino-1,5-dioxo-1-[[(2S)-1-oxopropan-2-yl]amino]pentan-2-yl]amino]-1-(2-amino-1,4,5,6-tetrahydropyrimidin-6-yl)-2-oxoethyl]carbamoylamino]-4-methylpentanoic acid

Elastatinal, elastase inhibitor

51798-45-9

C21H36N8O7

C21H36N8O6

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