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ELASTATINAL

Product Name
ELASTATINAL
CAS No.
51798-45-9
Chemical Name
ELASTATINAL
Synonyms
ELASTATINAL;AIDS-006470;Leu-co-cpd-Gln-Ala-h;ELASTATINAL USP/EP/BP;elastatinal from microbial source;N-[-N-ALPHA-CARBONYL-CPD-GLN-ALA-AL]-LEU;l-glutamamide,l-2-(2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl-n-(((1-carboxy-3-m;N-[(S)-1-CARBOXYISOPENTYL]CARBAMOYL-ALPHA-[2-IMINOHEXAHYDRO-4(S)-PYRIMIDYL-(S)-GLYCYL-(S)-GLUTAMINYL-(S)-ALANINAL];Nα-[2-(2-Amino-1,4,5,6-tetrahydropyrimidin-4-yl)-N-[[(1-carboxy-3-methylbutyl)amino]carbonyl]-L-glycyl]-N1-(1-methyl-2-oxoethyl)-L-glutaminamide;L-Glutamamide, (2S)-2-(4S)-2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl-N-(1S)-1-carboxy-3-methylbutylaminocarbonylglycyl-N1-(1S)-1-methyl-2-oxoethyl-
CBNumber
CB1249000
Molecular Formula
C21H36N8O7
Formula Weight
512.56
MOL File
51798-45-9.mol
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ELASTATINAL Property

storage temp. 
-20°C
solubility 
H2O: 20 mg/mL, clear, yellow
form 
Yellow solid.
color 
off-white
BRN 
873543
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
LZ9600000
F 
10
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E0881
Product name
Elastatinal
Purity
microbial
Packaging
5mg
Price
$181
Updated
2024/03/01
Sigma-Aldrich
Product number
E0881
Product name
Elastatinal
Purity
microbial
Packaging
10mg
Price
$330
Updated
2024/03/01
Alfa Aesar
Product number
J61120
Product name
Elastatinal
Packaging
5mg
Price
$147
Updated
2023/06/20
Alfa Aesar
Product number
J61120
Product name
Elastatinal
Packaging
25mg
Price
$432
Updated
2021/12/16
Cayman Chemical
Product number
22288
Product name
Elastatinal
Purity
≥95%
Packaging
5mg
Price
$93
Updated
2024/03/01
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ELASTATINAL Chemical Properties,Usage,Production

Description

Elastatinal is a potent inhibitor of pancreatic elastase (Ki = 240 nM) that is produced by various species of Actinomycetes. It more strongly inhibits pancreatic elastase versus the leukocyte-derived enzyme. Elastatinal reduces electrophoretic mobilities of 2A proteinases from poliovirus and human rhinovirus 14 in a dose-dependent manner, indicating substrate recognition by 2A proteinases is similar to that of pancreatic elastases. It can also inhibit elastase-like protease collagenolytic protease from C. maenas digestive glands.

Uses

Elastatinal is an elastase inhibitor.

Biochem/physiol Actions

Potent, irreversible elastase inhibitor. Elastatinal is a much stronger inhibitor of elastase from pancreas than from leucocytes.

References

1) Umezawa et al. (1973), Letter: Elastatinal, a new elastase inhibitor produced by actinomycetes; J. Antibiotics, 26 787 2) Nakajima et al. (1992), Identification of elastase as a secretory protease from cultured rat microglia; J. Neurochem., 58 1401 3) Molla et al. (1993), Inhibition of proteolytic activity of poliovirus and rhinovirus 2A proteases by elastase-specific inhibitors; J. Virol., 67 4688 4) Menendez-Arias et al. (1992), Isolation and characterization of alpha 2-macroglobulin-protease complexes from purified mouse mammary tumor virus and culture supernatants from virus-infected cell lines; J. Biol. Chem., 267 11392

ELASTATINAL Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ELASTATINAL manufacturers

Career Henan Chemical Co
Product
ELASTATINAL 51798-45-9
Price
US $1.00/g
Min. Order
1g
Purity
≥98%
Supply Ability
g/kg/Ton
Release date
2020-01-08

51798-45-9, ELASTATINALRelated Search:

ACTINONIN P-5091 6-fluoro-N-(4-fluorobenzyl)quinazolin-4-aMine ZPCK Elastatinal (1.24822) ELASTATINAL Dibutylurea

  • N-[-N-ALPHA-CARBONYL-CPD-GLN-ALA-AL]-LEU
  • elastatinal from microbial source
  • L-2-(2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl)-N-[[(1-carboxy-3-methylbutyl)amino]carbonyl]glycyl-N1-(1-methyl-2-oxoethyl)-L-glutamamide, stereoisomer
  • Leu-co-cpd-Gln-Ala-h
  • L-Glutamamide, (2S)-2-(4S)-2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl-N-(1S)-1-carboxy-3-methylbutylaminocarbonylglycyl-N1-(1S)-1-methyl-2-oxoethyl-
  • (2s)-2-[(4s)-2-amino-1,4,5,6-tetrahydro4-pyrimidinyl]-n-[[[(1s)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-n1-[(1s)-1-methyl-2-oxoethyl-l-glutamamide
  • AIDS-006470
  • Nα-[2-(2-Amino-1,4,5,6-tetrahydropyrimidin-4-yl)-N-[[(1-carboxy-3-methylbutyl)amino]carbonyl]-L-glycyl]-N1-(1-methyl-2-oxoethyl)-L-glutaminamide
  • (2S)-2-[(4S)-2-Amino-3,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N1-[(1S)-1-methyl-2-oxoethyl]-L-glutamamide
  • l-glutamamide,l-2-(2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl-n-(((1-carboxy-3-m
  • ELASTATINAL
  • N-[(S)-1-CARBOXYISOPENTYL]CARBAMOYL-ALPHA-[2-IMINOHEXAHYDRO-4(S)-PYRIMIDYL-(S)-GLYCYL-(S)-GLUTAMINYL-(S)-ALANINAL]
  • L-Glutamamide, (2S)-2-[(4S)-2-amino-3,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N1-[(1S)-1-methyl-2-oxoethyl]-
  • ELASTATINAL USP/EP/BP
  • (2S)-2-[[(1S)-2-[[(2S)-5-amino-1,5-dioxo-1-[[(2S)-1-oxopropan-2-yl]amino]pentan-2-yl]amino]-1-(2-amino-1,4,5,6-tetrahydropyrimidin-6-yl)-2-oxoethyl]carbamoylamino]-4-methylpentanoic acid
  • 51798-45-9
  • C21H36N8O7
  • C21H36N8O6
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