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LY2811376

Product Name
LY2811376
CAS No.
1194044-20-6
Chemical Name
LY2811376
Synonyms
CS-1893;LY2811376;LY2811376, >=98%;LY2811376 ，S1528;LY2811376 USP/EP/BP;LY 2811376;LY-2811376;LY2811376, 10 mM in DMSO;(4S)-4-(2,4-difluoro-5-pyriMidin-5-ylphenyl)-4-Methyl-5,6-dihydro-1,3-thiazin-2-aMine;(S)-4-(2,4-difluoro-5-(pyriMidin-5-yl)phenyl)-4-Methyl-5,6-dihydro-4H-1,3-thiazin-2-aMine;(4S)-4-[2,4-Difluoro-5-(5-pyrimidinyl)phenyl]-5,6-dihydro-4-methyl-4H-1,3-thiazin-2-amine
CBNumber
CB12502804
Molecular Formula
C15H14F2N4S
Formula Weight
320.36
MOL File
1194044-20-6.mol
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LY2811376 Property

Boiling point:
486.5±55.0 °C(Predicted)
Density 
1.42
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
crystalline solid
pka
5.60±0.40(Predicted)
color 
White to khaki
InChI
InChI=1S/C15H14F2N4S/c1-15(2-3-22-14(18)21-15)11-4-10(12(16)5-13(11)17)9-6-19-8-20-7-9/h4-8H,2-3H2,1H3,(H2,18,21)/t15-/m0/s1
InChIKey
MJQMRGWYPNIERM-HNNXBMFYSA-N
SMILES
S1CC[C@](C2=CC(C3=CN=CN=C3)=C(F)C=C2F)(C)N=C1N
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16712
Product name
LY2811376
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
16712
Product name
LY2811376
Purity
≥98%
Packaging
5mg
Price
$193
Updated
2024/03/01
Cayman Chemical
Product number
16712
Product name
LY2811376
Purity
≥98%
Packaging
10mg
Price
$341
Updated
2024/03/01
Cayman Chemical
Product number
16712
Product name
LY2811376
Purity
≥98%
Packaging
50mg
Price
$1062
Updated
2024/03/01
TRC
Product number
L486360
Product name
LY2811376
Packaging
50mg
Price
$815
Updated
2021/12/16
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LY2811376 Chemical Properties,Usage,Production

Uses

LY 281137 is a compound capable of the decrease in β-amyloid peptide (Aβ) associated with the cleavage of amyloid precursor protein (APP) by β-secretase (BACE) and γ-secretase. This decrease is important as its hypothesized that the build up of (Aβ) in the brain is a primary cause of neurodegeneration and Alzheimer’s progression.

in vivo

LY2811376 (10, 30, and 100 mg/kg, p.o.) results in dose-dependent, significant reductions in Aβ as well as sAPPβ and C99, the proximal cleavage products of APP proteolysis by BACE1. LY2811376 produces dose-dependent decreases in all APP-related PD markers of BACE1 inhibition in PDAPP mice. Low (30 mg) and high (90 mg) doses of LY2811376 investigated in the CSF sampling study are based on PK and plasma Aβ1-40 PD observed in the SAD study[1]. LY2811376 (30 mg/kg, p.o.) can lead to a 60% decrease in the soluble Aβs in mouse cortex[2]. LY2811376 (100 mg/kg, p.o.) decreases the spine density and formation in mice. LY2811376 (100 mg/kg every 12 hours over 16 days) causes a reduction in the frequency of sEPSC and mEPSC, whereas the effects of LY2811376 on the amplitude of sEPSC fails to reach significance[4].

IC 50

BACE1

LY2811376 Preparation Products And Raw materials

Raw materials

Preparation Products

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LY2811376 Suppliers

China 143 India 2 The Netherlands 1 United States 18 Global 164
AdooQ BioScience, LLC
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+1 (866) 930-6790
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+1 (866) 333-9607
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info@adooq.com
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ApexBio Technology LLC
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+1-832-696-8203
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BOC Sciences
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16314854226
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Target molecule Corp.
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857-239-0968
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857-239-8801
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service1@targetmol.com
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Musechem
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+1-800-259-7612
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+1-800-259-7612
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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United States
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InvivoChem
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Cckinase, Inc.
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Alchem Pharmtech,Inc.
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Aladdin Scientific
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Cayman Chemical Company
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Matrix Scientific
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View Lastest Price from LY2811376 manufacturers

PNP Biotech Co. Ltd
Product
(4S)-4-[2,4-Difluoro-5-(5-pyrimidinyl)phenyl]-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine 1194044-20-6
Price
US $0.00/kg
Min. Order
25kg
Purity
98%
Supply Ability
Inquiry
Release date
2023-07-10
Career Henan Chemical Co
Product
LY2811376 1194044-20-6
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-23

1194044-20-6, LY2811376Related Search:

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  • LY2811376
  • (4S)-4-[2,4-Difluoro-5-(5-pyrimidinyl)phenyl]-5,6-dihydro-4-methyl-4H-1,3-thiazin-2-amine
  • LY 2811376,(4S)-4-[2,4-Difluoro-5-(5-pyriMidinyl)phenyl]-5,6-dihydro-4-Methyl-4H-1,3-thiazin-2-aMine
  • CS-1893
  • LY 2811376;LY-2811376
  • (S)-4-(2,4-difluoro-5-(pyriMidin-5-yl)phenyl)-4-Methyl-5,6-dihydro-4H-1,3-thiazin-2-aMine
  • (4S)-4-(2,4-difluoro-5-pyriMidin-5-ylphenyl)-4-Methyl-5,6-dihydro-1,3-thiazin-2-aMine
  • N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride Tubastatin A HCl LY2811376
  • LY2811376, >=98%
  • 4H-1,3-Thiazin-2-amine, 4-[2,4-difluoro-5-(5-pyrimidinyl)phenyl]-5,6-dihydro-4-methyl-, (4S)-
  • LY2811376 USP/EP/BP
  • (4S)-4-[2,4-Difluoro-5-(5-pyrimidinyl)phenyl]-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine
  • LY2811376, 10 mM in DMSO
  • LY2811376 ，S1528
  • 1194044-20-6
  • C15H14F2N4S
  • Inhibitor
  • Inhibitors