PD318088

ChemicalBook > CAS DataBase List > PD318088

Product Name: PD318088
CAS No.: 391210-00-7
Chemical Name: PD318088
Synonyms: CS-395;PD318088;PD318088, >=98%;PD318088/PD-318088;PD318088 USP/EP/BP;PD318088;PD 318088;PD-318088;PD318088 Allosteric MEK1/2 inhibitor;5-Bromo-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide;BenzaMide, 5-broMo-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)aMino]-;Mitogen-activated protein kinase kinase,inhibit,MEK,MAPKK,MAP2K,PD-318088,Inhibitor,PD318088,PD 318088
CBNumber: CB12518278
Molecular Formula: C16H13BrF3IN2O4
Formula Weight: 561.09
MOL File: 391210-00-7.mol

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PD318088 Property

Density: 1.993
storage temp.: Store at -20°C
solubility: ≥28.05 mg/mL in DMSO; insoluble in H2O; ≥7.36 mg/mL in EtOH with ultrasonic
form: solid
pka: 13.42±0.20(Predicted)

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Safety

HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 30265
Product name: PD 318088
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 30265
Product name: PD 318088
Packaging: 25mg
Price: $692
Updated: 2024/03/01

Cayman Chemical

Product number: 30265
Product name: PD 318088
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 30265
Product name: PD 318088
Packaging: 10mg
Price: $341
Updated: 2024/03/01

ApexBio Technology

Product number: A5707
Product name: PD318088
Packaging: 25mg
Price: $360
Updated: 2021/12/16

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PD318088 Chemical Properties,Usage,Production

Biological Activity

pd318088 is an allosteric and non-atp competitive mek1/2 inhibitor.pd318088 is an analog of pd184352, which means it might have important anti-proliferative activity against cancer cells, although no functional study of pd318088 is currently available. pd318088 binds simultaneously with atp in a region of the mek1 active site that is adjacent to the atp-binding site. formation of the ternary complexes with pd318088 and mgatp results in moderate increases (to 140 nm) for the kd monomer-dimer for both mek1 and mek2. pd318088 and mgatp together increase the dimerization disassociation constant for mek1 and mek2 slightly from ~75 nm to ~140 nm [1].pd318088 is a biarylamine compound co-crystallized with mek. g8935 occupies the unique pocket adjacent to atp binding site and is uperimposed with pd318088 .pd318088 averts to use the pocket formed by ile216, phe209, arg189, and asp190. [2]

target

MEK1/2

References

1. ohren jf1, chen h, pavlovsky a et al. structures of human map kinase kinase 1 (mek1) and mek2 describe novel noncompetitive kinase inhibition. nat struct mol biol. 2004 dec;11(12):1192-7. epub 2004 nov 14.2. han s, zhou v, pan s et al. identification of coumarin derivatives as a novel class of allosteric mek1 inhibitors. bioorg med chem lett. 2005 dec 15;15(24):5467-73. epub 2005 sep 30.

PD318088 Preparation Products And Raw materials

Raw materials

Preparation Products

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391210-00-7, PD318088Related Search:

PD 166285 PD173955 PD 0325901 PD 166793 PD 98059 PD184352 Y27632 (hydrochloride) Selumetinib Celecoxib Donepezil Hydrochloride Saracatinib Cilnidipine

PD318088

BenzaMide, 5-broMo-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)aMino]-

5-Bromo-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide

PD318088/PD-318088

5-Bromo-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-[(2-fluoro-4- iodophenyl)amino]benzamide PD 318088

PD318088, >=98%

PD318088;PD 318088;PD-318088

CS-395

PD318088 USP/EP/BP

PD318088 Allosteric MEK1/2 inhibitor

Mitogen-activated protein kinase kinase,inhibit,MEK,MAPKK,MAP2K,PD-318088,Inhibitor,PD318088,PD 318088

391210-00-7

C16H13BrF3IN2O4

MAPK

Inhibitors