ChemicalBook > CAS DataBase List > N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide
N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide
- Product Name
- N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide
- CAS No.
- 72926-24-0
- Chemical Name
- N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide
- Synonyms
- K 858;K858;K-858;K858 (Racemic);inhibit,Inhibitor,K858 (Racemic),Apoptosis,K-858 (Racemic),Kinesin;N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide;N-(4-acetyl-5-methyl-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)a Cetamide;Acetamide, N-(4-acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)-
- CBNumber
- CB12518940
- Molecular Formula
- C13H15N3O2S
- Formula Weight
- 277.34
- MOL File
- 72926-24-0.mol
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N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide Property
- Melting point:
- 216-217 °C(Solv: ethanol (64-17-5))
- Density
- 1.27±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO: ≥20mg/mL
- form
- powder
- pka
- 8.61±0.40(Predicted)
- color
- white to off-white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- K3644
- Product name
- K 858
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $390
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- K3644
- Product name
- K 858
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $109
- Updated
- 2022/05/15
Cayman Chemical
- Product number
- 22112
- Product name
- K 858
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 22112
- Product name
- K 858
- Packaging
- 5mg
- Price
- $70
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 22112
- Product name
- K 858
- Packaging
- 10mg
- Price
- $122
- Updated
- 2024/03/01
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N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide Chemical Properties,Usage,Production
Description
K858 (72926-24-0) is a selective mitotic kinesin Eg5 inhibitor (IC50 = 1.3 μM) which acts in an ATP-noncompetitive manner.1,2?It is at least 150-fold more selective for Eg5 than other members of the kinesin superfamily. K-858 blocks centrosome separation, activates the spindle checkpoint and induces mitotic arrest accompanied by the formation of monopolar spindles. Displays no effect on microtubule polymerization. Selectively displays antiproliferative effects via induction of mitotic cell death in cancer cells over nontransformed cells.1
Uses
K 858 is a selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor.
Definition
ChEBI: N-(4-acetyl-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide is a member of benzenes.
References
1) Nakai et al. (2009), K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells; Cancer Res., 69 3901 2) Indorato et al. (2013), STLC-resistant cell lines as tools to classify chemically divergent Eg5 targeting agents according to their mode of action and target specificity; Biochem. Pharmacol.,?86?1441
N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide manufacturers
Career Henan Chemical Co
- Product
- N-(4-Acetyl-5-methyl-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)acetamide 72926-24-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-23