ChemicalBook > CAS DataBase List > N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide

N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide

Product Name
N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide
CAS No.
72926-24-0
Chemical Name
N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide
Synonyms
K 858;K858;K-858;K858 (Racemic);K858 (Racemic), 10 mM in DMSO;inhibit,Inhibitor,K858 (Racemic),Apoptosis,K-858 (Racemic),Kinesin;N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide;N-(4-acetyl-5-methyl-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)a Cetamide;Acetamide, N-(4-acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)-
CBNumber
CB12518940
Molecular Formula
C13H15N3O2S
Formula Weight
277.34
MOL File
72926-24-0.mol
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N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide Property

Melting point:
216-217 °C(Solv: ethanol (64-17-5))
Density 
1.27±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO: ≥20mg/mL
form 
powder
pka
8.61±0.40(Predicted)
color 
white to off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
K3644
Product name
K 858
Purity
≥98% (HPLC)
Packaging
25mg
Price
$272
Updated
2025/07/31
Sigma-Aldrich
Product number
K3644
Product name
K 858
Purity
≥98% (HPLC)
Packaging
5mg
Price
$109
Updated
2022/05/15
TCI Chemical
Product number
K0076
Product name
K 858
Packaging
25MG
Price
$289
Updated
2025/07/31
Cayman Chemical
Product number
22112
Product name
K 858
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
22112
Product name
K 858
Packaging
5mg
Price
$70
Updated
2024/03/01
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N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide Chemical Properties,Usage,Production

Description

K858 (72926-24-0) is a selective mitotic kinesin Eg5 inhibitor (IC50 = 1.3 μM) which acts in an ATP-noncompetitive manner.1,2?It is at least 150-fold more selective for Eg5 than other members of the kinesin superfamily. K-858 blocks centrosome separation, activates the spindle checkpoint and induces mitotic arrest accompanied by the formation of monopolar spindles. Displays no effect on microtubule polymerization. Selectively displays antiproliferative effects via induction of mitotic cell death in cancer cells over nontransformed cells.1

Uses

K 858 is a selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor.

Definition

ChEBI: N-(4-acetyl-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide is a member of benzenes.

in vivo

K858 (50, 150 mg/kg, p.o.) shows antitumor activity in an A2780 ovarian cancer xenograft model, also inhibits tumor grwoth in a HCT116 colon cancer xenograft model via 100 mg/kg twice a day orally for 5 days. K858 (100 mg/kg, p.o., qd ×5) displays no neurotoxic side effects in mice[1].

IC 50

Eg5: 1.3 μM (IC50)

References

[1] RYUICHIRO NAKAI. K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells.[J]. Cancer research, 2009, 69 9: 3901-3909. DOI:10.1158/0008-5472.can-08-4373
[2] ROSE-LAURE INDORATO . STLC-resistant cell lines as tools to classify chemically divergent Eg5 targeting agents according to their mode of action and target specificity[J]. Biochemical pharmacology, 2013, 86 10: Pages 1441-1451. DOI:10.1016/j.bcp.2013.09.003

N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide Suppliers

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Shanghai Boyle Chemical Co., Ltd.
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View Lastest Price from N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide manufacturers

Career Henan Chemical Co
Product
N-(4-Acetyl-5-methyl-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)acetamide 72926-24-0
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-23

72926-24-0, N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamideRelated Search:

S-Trityl-L-cysteine CYCLOPAMINE Brefeldin A TYRPHOSTIN AG 1296

  • K 858
  • N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide
  • N-(4-acetyl-5-methyl-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)a Cetamide
  • K858;K-858
  • K858 (Racemic)
  • Acetamide, N-(4-acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)-
  • inhibit,Inhibitor,K858 (Racemic),Apoptosis,K-858 (Racemic),Kinesin
  • K858 (Racemic), 10 mM in DMSO
  • 72926-24-0