6-chloro-5-Methylpyridazin-3-aMine
Appearance- Product Name
- 6-chloro-5-Methylpyridazin-3-aMine
- CAS No.
- 66346-87-0
- Chemical Name
- 6-chloro-5-Methylpyridazin-3-aMine
- Synonyms
- 6-chloro-5-Methylpyridazin-3-aMine;6-chloro-5-Methyl-3;Risdiplam Impurity 12;6-dihydropyridazin-3-aMine;6-Chloro-5-methyl-3-pyridazinamine;3-PyridazinaMine,6-chloro-5-Methyl-;6-Amino-3-chloro-4-methylpyridazine;(6-Chloro-5-methylpyridazin-3-yl)amine;Pyridazine, 6-amino-3-chloro-4-methyl-(6CI,7CI);6-chloro-5-Methyl-3,6-dihydropyridazin-3-aMine ISO 9001：2015 REACH
- CBNumber
- CB12538911
- Molecular Formula
- C5H6ClN3
- Formula Weight
- 143.57
- MOL File
- 66346-87-0.mol
6-chloro-5-Methylpyridazin-3-aMine Property
- Melting point:
- 190-191 °C(Solv: ethanol (64-17-5))
- Boiling point:
- 358.4±37.0 °C(Predicted)
- Density
- 1.349±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 4.98±0.10(Predicted)
- Appearance
- Off-white to yellow Solid
- InChI
- InChI=1S/C5H6ClN3/c1-3-2-4(7)8-9-5(3)6/h2H,1H3,(H2,7,8)
- InChIKey
- UWDLNRUFHRYMSE-UHFFFAOYSA-N
- SMILES
- C1(N)=NN=C(Cl)C(C)=C1
- CAS DataBase Reference
- 66346-87-0
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- C381945
- Product name
- 6-Chloro-5-methylpyridazin-3-amine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 3H30-5-7Q
- Product name
- 6-Chloro-5-methylpyridazin-3-amine
- Packaging
- 1g
- Price
- $456
- Updated
- 2021/12/16
- Product number
- HCH0367982
- Product name
- 6-CHLORO-5-METHYL-3,6-DIHYDROPYRIDAZIN-3-AMINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.68
- Updated
- 2021/12/16
- Product number
- 3H30-5-7Q
- Product name
- 6-Chloro-5-methylpyridazin-3-amine
- Packaging
- 5G
- Price
- $1080
- Updated
- 2021/12/16
- Product number
- A153266
- Product name
- 6-Chloro-5-methylpyridazin-3-amine
- Purity
- 98%
- Packaging
- 100mg
- Price
- $9
- Updated
- 2021/12/16
6-chloro-5-Methylpyridazin-3-aMine Chemical Properties,Usage,Production
Appearance
Pale-yellow to Yellow-brown Solid
Uses
6-CHLORO-5-METHYLPYRIDAZIN-3-AMINE is a useful research chemical.
Pharmaceutical Applications
6-Chloro-5-methylpyridazin-3-amine is used as an intermediate in pharmaceutical manufacturing, particularly in the synthesis of complex organic molecules. It is a crystalline solid and features prominently in the formation of novel drug compounds.
Synthesis
19064-64-3
66346-87-0
64068-00-4
The general procedure for the synthesis of 3-amino-5-methyl-6-chloropyridazine and 3-amino-4-methyl-6-chloropyridazine from 3,6-dichloro-4-methylpyridazine is as follows [Linholter, S., et al., Acta Chem. Scand. 15:1660-1666 (1961)]: to a 3,6-dichloro-4-methylpyridazine (200 mg) solution in ethanol (3 mL) was added to liquid ammonia (3 mL). The reaction mixture was placed in a sealed tube and heated at 120 °C for 12 hours. After completion of the reaction, it was cooled to room temperature and the methanol and ammonia were removed by evaporation. The residue was purified by fast chromatography (eluent: ethyl acetate) to give 153 mg of a mixture of 3-amino-5-methyl-6-chloropyridazine and 3-amino-4-methyl-6-chloropyridazine (1:1 ratio) in 87% yield. The mixture could be used directly for subsequent experiments without further separation.
References
[1] Patent: WO2007/33080, 2007, A2. Location in patent: Page/Page column 26; 37
[2] Patent: WO2014/72261, 2014, A1. Location in patent: Page/Page column 48
[3] Pharmaceutical Bulletin, 1957, vol. 5, p. 229,233
[4] Australian Journal of Chemistry, 1986, vol. 39, # 11, p. 1803 - 1809
[5] Pharmaceutical Bulletin, 1957, vol. 5, p. 229,233
6-chloro-5-Methylpyridazin-3-aMine Preparation Products And Raw materials
Raw materials
Preparation Products
6-chloro-5-Methylpyridazin-3-aMine Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from 6-chloro-5-Methylpyridazin-3-aMine manufacturers
- Product
- 6-chloro-5-Methyl-3,6-dihydropyridazin-3-aMine 66346-87-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-29
- Product
- 6-Chloro-5-methylpyridazin-3-amine 66346-87-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%minHPLC
- Supply Ability
- 50kgs/month
- Release date
- 2021-11-13
- Product
- 6-chloro-5-Methyl-3,6-dihydropyridazin-3-aMine 66346-87-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-11-02