6-CHLORO-7-METHYLPURINE
- Product Name
- 6-CHLORO-7-METHYLPURINE
- CAS No.
- 5440-17-5
- Chemical Name
- 6-CHLORO-7-METHYLPURINE
- Synonyms
- NSC 15192;7-METHYL-6-CHLOROPURINE;6-CHLORO-7-METHYLPURINE;6-Chloro-7-methyl-7H-purine;7H-Purine, 6-chloro-7-methyl-
- CBNumber
- CB1429820
- Molecular Formula
- C6H5ClN4
- Formula Weight
- 168.58
- MOL File
- 5440-17-5.mol
6-CHLORO-7-METHYLPURINE Property
- Melting point:
- 175-185°C
- Boiling point:
- 321.7±45.0 °C(Predicted)
- Density
- 1.59±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly)
- form
- Solid
- pka
- 0.65±0.30(Predicted)
- color
- Light Green to Grey-Blue
- CAS DataBase Reference
- 5440-17-5
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C369495
- Product name
- 6-Chloro-7-methylpurine
- Packaging
- 50mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- C5028-60
- Product name
- 6-Chloro-7-methylpurine
- Packaging
- 25mg
- Price
- $389
- Updated
- 2021/12/16
- Product number
- C369495
- Product name
- 6-Chloro-7-methylpurine
- Packaging
- 500mg
- Price
- $645
- Updated
- 2021/12/16
- Product number
- FC09543
- Product name
- 6-Chloro-7-methylpurine
- Packaging
- 10mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FC09543
- Product name
- 6-Chloro-7-methylpurine
- Packaging
- 25mg
- Price
- $100
- Updated
- 2021/12/16
6-CHLORO-7-METHYLPURINE Chemical Properties,Usage,Production
Chemical Properties
Light Green Solid
Uses
6-CHLORO-7-METHYLPURINE is a useful synthetic intermediate.
Synthesis
87-42-3
74-88-4
5440-17-5
To a 1L three-necked round-bottomed flask was added 6-chloro-9H-purine (15.4 g, 0.1 mol, 1 eq.) and tetrahydrofuran (155 mL) at 0 °C and protected by nitrogen in an inert atmosphere. Methylmagnesium chloride (MeMgCl, 36.6 mL, 1.0 M THF solution, 1.1 eq.) was added dropwise with stirring. The reaction mixture was continued to be stirred at 0 °C for 30 min. Subsequently, iodomethane (42.6 g, 3 eq.) was added slowly and dropwise with stirring. The resulting reaction solution was transferred to a 50 °C oil bath and the reaction was stirred for 5 hours. Upon completion of the reaction, the reaction was quenched by addition of 50 mL of aqueous ammonium chloride (NH4Cl) and extracted with dichloromethane (3 x 50 mL). The organic layers were combined and washed with brine (2 x 50 mL) and subsequently concentrated under vacuum. The crude product was recrystallized by dichloromethane/petroleum ether (1:10) to afford 6-chloro-7-methylpurine as a light green solid (7 g, 42% yield).
References
[1] Organic Letters, 2016, vol. 18, # 1, p. 16 - 19
[2] Patent: WO2018/96159, 2018, A1. Location in patent: Paragraph 0169-0172
6-CHLORO-7-METHYLPURINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-CHLORO-7-METHYLPURINE manufacturers
- Product
- 6-CHLORO-7-METHYLPURINE 5440-17-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 6-CHLORO-7-METHYLPURINE 5440-17-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- 6-CHLORO-7-METHYLPURINE 5440-17-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%-99.99%
- Supply Ability
- 1kg-10MT
- Release date
- 2019-05-24