6-chloro-5-Methylpyridazin-3-aMine

Appearance

Product Name: 6-chloro-5-Methylpyridazin-3-aMine
CAS No.: 66346-87-0
Chemical Name: 6-chloro-5-Methylpyridazin-3-aMine
Synonyms: 6-chloro-5-Methylpyridazin-3-aMine;6-chloro-5-Methyl-3;Risdiplam Impurity 12;6-dihydropyridazin-3-aMine;6-Chloro-5-methyl-3-pyridazinamine;3-PyridazinaMine,6-chloro-5-Methyl-;6-Amino-3-chloro-4-methylpyridazine;(6-Chloro-5-methylpyridazin-3-yl)amine;Pyridazine, 6-amino-3-chloro-4-methyl-(6CI,7CI);6-chloro-5-Methyl-3,6-dihydropyridazin-3-aMine ISO 9001：2015 REACH
CBNumber: CB12538911
Molecular Formula: C5H6ClN3
Formula Weight: 143.57
MOL File: 66346-87-0.mol

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6-chloro-5-Methylpyridazin-3-aMine Property

Melting point:: 190-191 °C(Solv: ethanol (64-17-5))
Boiling point:: 358.4±37.0 °C(Predicted)
Density: 1.349±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 4.98±0.10(Predicted)
Appearance: Off-white to yellow Solid
InChI: InChI=1S/C5H6ClN3/c1-3-2-4(7)8-9-5(3)6/h2H,1H3,(H2,7,8)
InChIKey: UWDLNRUFHRYMSE-UHFFFAOYSA-N
SMILES: C1(N)=NN=C(Cl)C(C)=C1
CAS DataBase Reference: 66346-87-0

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: C381945
Product name: 6-Chloro-5-methylpyridazin-3-amine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-5-7Q
Product name: 6-Chloro-5-methylpyridazin-3-amine
Packaging: 1g
Price: $456
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0367982
Product name: 6-CHLORO-5-METHYL-3,6-DIHYDROPYRIDAZIN-3-AMINE
Purity: 95.00%
Packaging: 5MG
Price: $504.68
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-5-7Q
Product name: 6-Chloro-5-methylpyridazin-3-amine
Packaging: 5G
Price: $1080
Updated: 2021/12/16

Ambeed

Product number: A153266
Product name: 6-Chloro-5-methylpyridazin-3-amine
Purity: 98%
Packaging: 100mg
Price: $9
Updated: 2021/12/16

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6-chloro-5-Methylpyridazin-3-aMine Chemical Properties,Usage,Production

Appearance

Pale-yellow to Yellow-brown Solid

Uses

6-CHLORO-5-METHYLPYRIDAZIN-3-AMINE is a useful research chemical.

Pharmaceutical Applications

6-Chloro-5-methylpyridazin-3-amine is used as an intermediate in pharmaceutical manufacturing, particularly in the synthesis of complex organic molecules. It is a crystalline solid and features prominently in the formation of novel drug compounds.

Synthesis

19064-64-3

66346-87-0

64068-00-4

The general procedure for the synthesis of 3-amino-5-methyl-6-chloropyridazine and 3-amino-4-methyl-6-chloropyridazine from 3,6-dichloro-4-methylpyridazine is as follows [Linholter, S., et al., Acta Chem. Scand. 15:1660-1666 (1961)]: to a 3,6-dichloro-4-methylpyridazine (200 mg) solution in ethanol (3 mL) was added to liquid ammonia (3 mL). The reaction mixture was placed in a sealed tube and heated at 120 °C for 12 hours. After completion of the reaction, it was cooled to room temperature and the methanol and ammonia were removed by evaporation. The residue was purified by fast chromatography (eluent: ethyl acetate) to give 153 mg of a mixture of 3-amino-5-methyl-6-chloropyridazine and 3-amino-4-methyl-6-chloropyridazine (1:1 ratio) in 87% yield. The mixture could be used directly for subsequent experiments without further separation.

References

[1] Patent: WO2007/33080, 2007, A2. Location in patent: Page/Page column 26; 37
[2] Patent: WO2014/72261, 2014, A1. Location in patent: Page/Page column 48
[3] Pharmaceutical Bulletin, 1957, vol. 5, p. 229,233
[4] Australian Journal of Chemistry, 1986, vol. 39, # 11, p. 1803 - 1809
[5] Pharmaceutical Bulletin, 1957, vol. 5, p. 229,233

6-chloro-5-Methylpyridazin-3-aMine Preparation Products And Raw materials

Raw materials

Preparation Products

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6-chloro-5-Methylpyridazin-3-aMine Suppliers

China 111 India 1 United Kingdom 1 United States 7 Global 120

SiChuang NanBu Honesty Technology Co., Ltd.

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Energy Chemical

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Santai Labs, Inc.

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View Lastest Price from 6-chloro-5-Methylpyridazin-3-aMine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 6-chloro-5-Methyl-3,6-dihydropyridazin-3-aMine 66346-87-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-29

Shanghai Rlavie Technology Co ltd

Product: 6-Chloro-5-methylpyridazin-3-amine 66346-87-0
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 98%minHPLC
Supply Ability: 50kgs/month
Release date: 2021-11-13

Dideu Industries Group Limited

Product: 6-chloro-5-Methyl-3,6-dihydropyridazin-3-aMine 66346-87-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-11-02

66346-87-0, 6-chloro-5-Methylpyridazin-3-aMineRelated Search:

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66346-87-0

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