6-Chloro-4-methylpyridazin-3-amine

Product Name: 6-Chloro-4-methylpyridazin-3-amine
CAS No.: 64068-00-4
Chemical Name: 6-Chloro-4-methylpyridazin-3-amine
Synonyms: 6-chloro-4-Methylpyridazin-3-aMine;Risdiplam Impurity 5;6-chloro-4-methyl-3-Pyridazinamine;3-PyridazinaMine, 6-chloro-4-Methyl-;3-PyridazinaMine, 6-chloro-4-Methyl-3-PyridazinaMine, 6-chloro-4-Methyl-
CBNumber: CB92637722
Molecular Formula: C5H6ClN3
Formula Weight: 143.57
MOL File: 64068-00-4.mol

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6-Chloro-4-methylpyridazin-3-amine Property

Melting point:: 137 °C
Boiling point:: 360.2±37.0 °C(Predicted)
Density: 1.349±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 4.49±0.10(Predicted)
Appearance: Off-white to light brown Solid
InChI: InChI=1S/C5H6ClN3/c1-3-2-4(6)8-9-5(3)7/h2H,1H3,(H2,7,9)
InChIKey: HSAHCMOZFNSMLH-UHFFFAOYSA-N
SMILES: C1(N)=NN=C(Cl)C=C1C

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: C384333
Product name: 6-Chloro-4-methylpyridazin-3-amine
Packaging: 1g
Price: $70
Updated: 2021/12/16

TRC

Product number: C384333
Product name: 6-Chloro-4-methylpyridazin-3-amine
Packaging: 250mg
Price: $40
Updated: 2021/12/16

Apolloscientific

Product number: OR920838
Product name: 6-Chloro-4-methylpyridazin-3-amine
Purity: 97%
Packaging: 250mg
Price: $43
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC139963
Product name: 6-Chloro-4-methylpyridazin-3-amine
Packaging: 100mg
Price: $70
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-5-A2
Product name: 6-Chloro-4-methylpyridazin-3-amine
Purity: 97%
Packaging: 1g
Price: $696
Updated: 2021/12/16

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6-Chloro-4-methylpyridazin-3-amine Chemical Properties,Usage,Production

Uses

6-Chloro-4-methylpyridazin-3-amine is a reagent used in organic synthesis transformations.

Synthesis

19064-64-3

66346-87-0

64068-00-4

General procedure for the synthesis of 3-amino-5-methyl-6-chloropyridazine and 3-amino-4-methyl-6-chloropyridazine from 3,6-dichloro-4-methylpyridazine: [Linholter, S., et al., Acta Chem. Scand. 15:1660-1666 (1961)]. To a solution of 3,6-dichloro-4-methylpyridazine (200 mg) in ethanol (3 mL) was added liquid ammonia (3 mL). The reaction mixture was placed in a sealed tube and heated at 120 °C for 12 hours. After completion of the reaction, it was cooled to room temperature and the methanol and ammonia were removed by evaporation. The residue was purified by fast chromatography (eluent: ethyl acetate) to give 153 mg of a mixture of 3-amino-5-methyl-6-chloropyridazine and 3-amino-4-methyl-6-chloropyridazine (1:1 ratio) in 87% yield. The mixture was used directly in the subsequent reaction without further separation.

References

[1] Patent: WO2007/33080, 2007, A2. Location in patent: Page/Page column 26; 37
[2] Patent: WO2014/72261, 2014, A1. Location in patent: Page/Page column 48
[3] Pharmaceutical Bulletin, 1957, vol. 5, p. 229,233
[4] Australian Journal of Chemistry, 1986, vol. 39, # 11, p. 1803 - 1809
[5] Pharmaceutical Bulletin, 1957, vol. 5, p. 229,233

6-Chloro-4-methylpyridazin-3-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Chloro-4-methylpyridazin-3-amine Suppliers

China 111 India 2 United Kingdom 1 United States 3 Global 117

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View Lastest Price from 6-Chloro-4-methylpyridazin-3-amine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 6-chloro-4-methylpyridazin-3-amine 64068-00-4
Price: US $0.10-10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200TONS
Release date: 2025-08-18

Apeloa production Co.,Limited

Product: 3-Pyridazinamine, 6-chloro-4-Methyl- 64068-00-4
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1999
Release date: 2024-06-17

Jiangsu Magic Biotechnology Co., Ltd

Product: 6-Chloro-4-Methylpyridazin-3-Amine 64068-00-4
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 99.2%
Supply Ability: 20tons
Release date: 2022-12-06

64068-00-4, 6-Chloro-4-methylpyridazin-3-amineRelated Search:

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Risdiplam Impurity 5

64068-00-4

Risdiplam