3-Amino-4-bromo-6-chloropyridazine

Appearance

Product Name: 3-Amino-4-bromo-6-chloropyridazine
CAS No.: 446273-59-2
Chemical Name: 3-Amino-4-bromo-6-chloropyridazine
Synonyms: 3-Amino-4-bromo-6-chL;3-AMino-4-broMo-6-chlorop...;4-Bromo-6-chloro-3-pyridazinamine;3-PyridazinaMine,4-broMo-6-chloro-;4-bromo-6-chloro-3-pyridazineamine;3-Amino-4-bromo-6-chloropyridazine;3-Amino-4-bromo-6-chloropyridazine 98%;3-Amino-4-bromo-6-chloropyridazine ISO 9001：2015 REACH
CBNumber: CB22134888
Molecular Formula: C4H3BrClN3
Formula Weight: 208.44
MOL File: 446273-59-2.mol

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3-Amino-4-bromo-6-chloropyridazine Property

Boiling point:: 385.4±37.0 °C(Predicted)
Density: 1.960
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 1.93±0.10(Predicted)
form: powder
color: Light brown to brown
InChI: InChI=1S/C4H3BrClN3/c5-2-1-3(6)8-9-4(2)7/h1H,(H2,7,9)
InChIKey: FGOWNGCSUSKHQI-UHFFFAOYSA-N
SMILES: C1(N)=NN=C(Cl)C=C1Br

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN2811
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS020016
Product name: 3-Amino-4-bromo-6-chloropyridazine
Purity: Aldrich<SUP>CPR</SUP>
Packaging: 100 mg
Price: $73.1
Updated: 2025/07/31

TRC

Product number: B680470
Product name: 4-Bromo-6-chloropyridazin-3-amine
Packaging: 50g
Price: $1595
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0044316
Product name: 4-BROMO-6-CHLOROPYRIDAZIN-3-AMINE
Purity: 95.00%
Packaging: 10G
Price: $1785.63
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-D-15
Product name: 4-Bromo-6-chloropyridazin-3-amine
Purity: 95%
Packaging: 25g
Price: $1198
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0044316
Product name: 4-BROMO-6-CHLOROPYRIDAZIN-3-AMINE
Purity: 95.00%
Packaging: 5G
Price: $1277.43
Updated: 2021/12/16

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3-Amino-4-bromo-6-chloropyridazine Chemical Properties,Usage,Production

Appearance

Pale-yellow to yellow-brown Solid

Uses

4-Bromo-6-chloropyridazin-3-amine is a compound involved in the preparation of novel potent imidazo[1,2-b]pyridazine PDE10a inhibitors.

Synthesis

5469-69-2

446273-59-2

Example I (1) Bromine (9.71 g, 3.15 mL, 60.75 mmol) was slowly added dropwise to a mixed solution containing 3-amino-6-chloropyridazine (7.87 g, 60.75 mmol), methanol (115 mL) and sodium bicarbonate (10.22 g, 121.67 mmol). The reaction mixture was stirred at room temperature for 16 hours and then filtered. Water (500 mL) was added to the filtrate and subsequently extracted with ethyl acetate (3 × 500 mL). The organic layers were combined and concentrated under reduced pressure. The resulting residue was purified by fast chromatography using 1:1 hexane/ethyl acetate as eluent, resulting in 5.40 g of 3-amino-4-bromo-6-chloropyridazine in 43% yield.

References

[1] Patent: WO2014/9305, 2014, A1. Location in patent: Page/Page column 29
[2] Patent: US2015/203498, 2015, A1. Location in patent: Paragraph 0155; 0156; 0157
[3] Patent: WO2009/100375, 2009, A1. Location in patent: Page/Page column 44-45
[4] Patent: WO2010/42699, 2010, A1. Location in patent: Page/Page column 114-115
[5] Journal of Medicinal Chemistry, 2012, vol. 55, # 23, p. 10414 - 10423

3-Amino-4-bromo-6-chloropyridazine Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Amino-4-bromo-6-chloropyridazine Suppliers

China 254 India 2 Japan 1 United Kingdom 1 United States 12 Global 270

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: (5)02557626880
Email: dt3@aikonchem.com
Country: China
ProdList: 15493
Advantage: 58

Shanghai NAIFU Biotechnology Co., Ltd

Tel: 18939876937 18939876937;
Email: sales@naifuchem.com
Country: China
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Advantage: 58

Shandong Shenke Pharmaceutical Technology Co. , Ltd.

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Email: 105935525@qq.com
Country: China
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Advantage: 58

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Email: SY06@accelachem.com
Country: China
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J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
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Beijing HwrkChemical Technology Co., Ltd

Tel: 18515581800 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9400
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Energy Chemical

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Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
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Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

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View Lastest Price from 3-Amino-4-bromo-6-chloropyridazine manufacturers

Jinan Ruitong Biotech Co., Ltd.

Product: 3-Amino-4-bromo-6-chloropyridazine 446273-59-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-29

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 3-Amino-4-bromo-6-chloropyridazine 446273-59-2
Price: US $1.60-6.60/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-19

Apeloa production Co.,Limited

Product: 3-Amino-4-bromo-6-chloropyridazine 446273-59-2
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 50000
Release date: 2024-06-17

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3-Amino-4-bromo-6-chloropyridazine

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3-AMino-4-broMo-6-chlorop...

4-bromo-6-chloro-3-pyridazineamine

3-PyridazinaMine,4-broMo-6-chloro-

3-Amino-4-bromo-6-chL

3-Amino-4-bromo-6-chloropyridazine ISO 9001：2015 REACH

3-Amino-4-bromo-6-chloropyridazine 98%

446273-59-2

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