6-Chloro-4-methylpyridazin-3-amine
- Product Name
- 6-Chloro-4-methylpyridazin-3-amine
- CAS No.
- 64068-00-4
- Chemical Name
- 6-Chloro-4-methylpyridazin-3-amine
- Synonyms
- 6-chloro-4-Methylpyridazin-3-aMine;Risdiplam Impurity 5;6-chloro-4-methyl-3-Pyridazinamine;3-PyridazinaMine, 6-chloro-4-Methyl-;3-PyridazinaMine, 6-chloro-4-Methyl-3-PyridazinaMine, 6-chloro-4-Methyl-
- CBNumber
- CB92637722
- Molecular Formula
- C5H6ClN3
- Formula Weight
- 143.57
- MOL File
- 64068-00-4.mol
6-Chloro-4-methylpyridazin-3-amine Property
- Melting point:
- 137 °C
- Boiling point:
- 360.2±37.0 °C(Predicted)
- Density
- 1.349±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 4.49±0.10(Predicted)
- Appearance
- Off-white to light brown Solid
- InChI
- InChI=1S/C5H6ClN3/c1-3-2-4(6)8-9-5(3)7/h2H,1H3,(H2,7,9)
- InChIKey
- HSAHCMOZFNSMLH-UHFFFAOYSA-N
- SMILES
- C1(N)=NN=C(Cl)C=C1C
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C384333
- Product name
- 6-Chloro-4-methylpyridazin-3-amine
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- C384333
- Product name
- 6-Chloro-4-methylpyridazin-3-amine
- Packaging
- 250mg
- Price
- $40
- Updated
- 2021/12/16
- Product number
- OR920838
- Product name
- 6-Chloro-4-methylpyridazin-3-amine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $43
- Updated
- 2021/12/16
- Product number
- FC139963
- Product name
- 6-Chloro-4-methylpyridazin-3-amine
- Packaging
- 100mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- 3H30-5-A2
- Product name
- 6-Chloro-4-methylpyridazin-3-amine
- Purity
- 97%
- Packaging
- 1g
- Price
- $696
- Updated
- 2021/12/16
6-Chloro-4-methylpyridazin-3-amine Chemical Properties,Usage,Production
Uses
6-Chloro-4-methylpyridazin-3-amine is a reagent used in organic synthesis transformations.
Synthesis
19064-64-3
66346-87-0
64068-00-4
General procedure for the synthesis of 3-amino-5-methyl-6-chloropyridazine and 3-amino-4-methyl-6-chloropyridazine from 3,6-dichloro-4-methylpyridazine: [Linholter, S., et al., Acta Chem. Scand. 15:1660-1666 (1961)]. To a solution of 3,6-dichloro-4-methylpyridazine (200 mg) in ethanol (3 mL) was added liquid ammonia (3 mL). The reaction mixture was placed in a sealed tube and heated at 120 °C for 12 hours. After completion of the reaction, it was cooled to room temperature and the methanol and ammonia were removed by evaporation. The residue was purified by fast chromatography (eluent: ethyl acetate) to give 153 mg of a mixture of 3-amino-5-methyl-6-chloropyridazine and 3-amino-4-methyl-6-chloropyridazine (1:1 ratio) in 87% yield. The mixture was used directly in the subsequent reaction without further separation.
References
[1] Patent: WO2007/33080, 2007, A2. Location in patent: Page/Page column 26; 37
[2] Patent: WO2014/72261, 2014, A1. Location in patent: Page/Page column 48
[3] Pharmaceutical Bulletin, 1957, vol. 5, p. 229,233
[4] Australian Journal of Chemistry, 1986, vol. 39, # 11, p. 1803 - 1809
[5] Pharmaceutical Bulletin, 1957, vol. 5, p. 229,233
6-Chloro-4-methylpyridazin-3-amine Preparation Products And Raw materials
Raw materials
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View Lastest Price from 6-Chloro-4-methylpyridazin-3-amine manufacturers
- Product
- 6-chloro-4-methylpyridazin-3-amine 64068-00-4
- Price
- US $0.10-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200TONS
- Release date
- 2025-08-18
- Product
- 3-Pyridazinamine, 6-chloro-4-Methyl- 64068-00-4
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1999
- Release date
- 2024-06-17
- Product
- 6-Chloro-4-Methylpyridazin-3-Amine 64068-00-4
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 99.2%
- Supply Ability
- 20tons
- Release date
- 2022-12-06