6-CHLORO-9-METHYLPURINE
- Product Name
- 6-CHLORO-9-METHYLPURINE
- CAS No.
- 2346-74-9
- Chemical Name
- 6-CHLORO-9-METHYLPURINE
- Synonyms
- 6-CHLORO-9-METHYL-9H-PURINE;NSC 4948;AKOS BBS-00003131;IFLAB-BB F1371-0159;OTAVA-BB BB7216640145;9-METHYL-6-CHLOROPURINE;6-CHLORO-9-METHYLPURINE;9H-Purine, 6-chloro-9-methyl-;8a-(2,4-dimethylphenyl)-3,4,7,8-tetrahydro-2H-pyrrolo[2,1-b][1,3]oxazin-6-one
- CBNumber
- CB4223083
- Molecular Formula
- C6H5ClN4
- Formula Weight
- 168.58
- MOL File
- 2346-74-9.mol
6-CHLORO-9-METHYLPURINE Property
- Melting point:
- 129-134oC
- Boiling point:
- 321.7±45.0 °C(Predicted)
- Density
- 1.59±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- form
- Solid
- pka
- 1.26±0.10(Predicted)
- color
- Off-White
- CAS DataBase Reference
- 2346-74-9(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C369500
- Product name
- 6-Chloro-9-methylpurine
- Packaging
- 100mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- C5028-60C
- Product name
- 6-Chloro-9-methylpurine
- Packaging
- 100mg
- Price
- $403
- Updated
- 2021/12/16
- Product number
- 295628
- Product name
- 6-Chloro-9-methylpurine
- Packaging
- 50mg
- Price
- $432
- Updated
- 2021/12/16
- Product number
- NC11301
- Product name
- 6-Chloro-9-methylpurine
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- NC11301
- Product name
- 6-Chloro-9-methylpurine
- Packaging
- 100mg
- Price
- $95
- Updated
- 2021/12/16
6-CHLORO-9-METHYLPURINE Chemical Properties,Usage,Production
Chemical Properties
6-CHLORO-9-METHYLPURINE is Pale Yellow Solid
Uses
6-CHLORO-9-METHYLPURINE is a useful synthetic intermediate
Uses
A useful synthetic intermediate.
Synthesis Reference(s)
Journal of the American Chemical Society, 79, p. 490, 1957 DOI: 10.1021/ja01559a069
Synthesis
87-42-3
74-88-4
2346-74-9
To a solution of 6-chloro-9H-purine (3.00 g, 20.0 mmol) in anhydrous THF (100 mL) cooled to 0°C was added 60% sodium hydride (1.2 g, 30.0 mmol) in portions. The reaction mixture was stirred in an ice bath for 0.5 h. Then iodomethane (2.82 g, 20.0 mmol) was slowly added and stirring was continued for 1 h at room temperature. After completion of the reaction, the mixture was diluted with 100 mL of water and extracted with ethyl acetate (30 mL x 3). The organic layers were combined, dried with anhydrous magnesium chloride and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography with the eluent being a 20% ethyl acetate/petroleum ether solvent mixture. The white solid product 9-methyl-6-chloropurine was obtained in 74.6% (2.50 g) yield. The product was analyzed by ESI-MS, m/z: 169.1 [M + H]+; 1H NMR (300 MHz, DMSO-d6) δ: 3.72 (3H, s, CH3), 8.72 (1H, s, H-purine), 9.15 (1H, s, H-purine).
References
[1] European Journal of Medicinal Chemistry, 2014, vol. 89, p. 581 - 596
[2] Synthesis, 2007, # 2, p. 219 - 224
[3] Angewandte Chemie - International Edition, 2018, vol. 57, # 18, p. 5134 - 5138
[4] Angew. Chem., 2018, vol. 130, # 18, p. 5228 - 5232,5
[5] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 1, p. 139 - 149
6-CHLORO-9-METHYLPURINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-CHLORO-9-METHYLPURINE manufacturers
- Product
- 6-CHLORO-9-METHYLPURINE 2346-74-9
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10tons
- Release date
- 2018-12-24