ChemicalBook > CAS DataBase List > 6-CHLORO-9-METHYLPURINE

6-CHLORO-9-METHYLPURINE

Product Name
6-CHLORO-9-METHYLPURINE
CAS No.
2346-74-9
Chemical Name
6-CHLORO-9-METHYLPURINE
Synonyms
6-CHLORO-9-METHYL-9H-PURINE;NSC 4948;AKOS BBS-00003131;IFLAB-BB F1371-0159;OTAVA-BB BB7216640145;9-METHYL-6-CHLOROPURINE;6-CHLORO-9-METHYLPURINE;9H-Purine, 6-chloro-9-methyl-;8a-(2,4-dimethylphenyl)-3,4,7,8-tetrahydro-2H-pyrrolo[2,1-b][1,3]oxazin-6-one
CBNumber
CB4223083
Molecular Formula
C6H5ClN4
Formula Weight
168.58
MOL File
2346-74-9.mol
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6-CHLORO-9-METHYLPURINE Property

Melting point:
129-134oC
Boiling point:
321.7±45.0 °C(Predicted)
Density 
1.59±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly)
form 
Solid
pka
1.26±0.10(Predicted)
color 
Off-White
CAS DataBase Reference
2346-74-9(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C369500
Product name
6-Chloro-9-methylpurine
Packaging
100mg
Price
$110
Updated
2021/12/16
Usbiological
Product number
C5028-60C
Product name
6-Chloro-9-methylpurine
Packaging
100mg
Price
$403
Updated
2021/12/16
Usbiological
Product number
295628
Product name
6-Chloro-9-methylpurine
Packaging
50mg
Price
$432
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
NUC0000666
Product name
6-CHLORO-9-METHYLPURINE
Purity
95.00%
Packaging
250MG
Price
$670
Updated
2021/12/16
Biosynth Carbosynth
Product number
NC11301
Product name
6-Chloro-9-methylpurine
Packaging
100mg
Price
$95
Updated
2021/12/16
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6-CHLORO-9-METHYLPURINE Chemical Properties,Usage,Production

Chemical Properties

6-CHLORO-9-METHYLPURINE is Pale Yellow Solid

Uses

6-CHLORO-9-METHYLPURINE is a useful synthetic intermediate

Uses

A useful synthetic intermediate.

Synthesis Reference(s)

Journal of the American Chemical Society, 79, p. 490, 1957 DOI: 10.1021/ja01559a069

Synthesis

87-42-3

74-88-4

2346-74-9

To a solution of 6-chloro-9H-purine (3.00 g, 20.0 mmol) in anhydrous THF (100 mL) cooled to 0°C was added 60% sodium hydride (1.2 g, 30.0 mmol) in portions. The reaction mixture was stirred in an ice bath for 0.5 h. Then iodomethane (2.82 g, 20.0 mmol) was slowly added and stirring was continued for 1 h at room temperature. After completion of the reaction, the mixture was diluted with 100 mL of water and extracted with ethyl acetate (30 mL x 3). The organic layers were combined, dried with anhydrous magnesium chloride and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography with the eluent being a 20% ethyl acetate/petroleum ether solvent mixture. The white solid product 9-methyl-6-chloropurine was obtained in 74.6% (2.50 g) yield. The product was analyzed by ESI-MS, m/z: 169.1 [M + H]+; 1H NMR (300 MHz, DMSO-d6) δ: 3.72 (3H, s, CH3), 8.72 (1H, s, H-purine), 9.15 (1H, s, H-purine).

References

[1] European Journal of Medicinal Chemistry, 2014, vol. 89, p. 581 - 596
[2] Synthesis, 2007, # 2, p. 219 - 224
[3] Angewandte Chemie - International Edition, 2018, vol. 57, # 18, p. 5134 - 5138
[4] Angew. Chem., 2018, vol. 130, # 18, p. 5228 - 5232,5
[5] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 1, p. 139 - 149

6-CHLORO-9-METHYLPURINE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-CHLORO-9-METHYLPURINE Suppliers

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View Lastest Price from 6-CHLORO-9-METHYLPURINE manufacturers

Career Henan Chemical Co
Product
6-CHLORO-9-METHYLPURINE 2346-74-9
Price
US $8.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10tons
Release date
2018-12-24

2346-74-9, 6-CHLORO-9-METHYLPURINERelated Search:

2,6-Dichloropurine-2'-deoxyriboside 6-CHLORO-9-(TETRAHYDRO-2-PYRANYL)-PURINE 6-Chloropurine ribonucleoside 6-CHLOROPURINE-2'-DEOXYRIBOSIDE 6-Chloropurine 2-Amino-6-chloropurine Riboside 6-CHLORO-5'-O-(DIMETHOXYTRITYL)PURINE-2'-DEOXYRIBOSIDE 2-AMINO-6-CHLORO-9-(BETA-D-2-DEOXYRIBOFURANOSYL)PURINE 2,6-DICHLORO-9-METHYL-9H-PURINE 6-chloro-9-cyclopentyl-9H-purine 2-AMINO-6-CHLORO-9H-PURINE-9-ACETIC ACID 6-CHLOROPURINE GLUCOSIDE 9-BENZYL-6-CHLORO-9H-PURINE 6-CHLORO-9-(3,5-O-DI(P-TOLUOYL)-BETA-D-2-DEOXYRIBOFURANOSYL) PURINE 6-CHLORO-9-METHYLPURINE 9-[2,3,5-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL]-2,6-DICHLOROPURINE 6-CHLORO-7-METHYLPURINE 6-AMINO-2-CHLORO-7-METHYLPURINE

  • OTAVA-BB BB7216640145
  • 6-CHLORO-9-METHYL-9H-PURINE
  • 6-CHLORO-9-METHYLPURINE
  • 9-METHYL-6-CHLOROPURINE
  • 8a-(2,4-dimethylphenyl)-3,4,7,8-tetrahydro-2H-pyrrolo[2,1-b][1,3]oxazin-6-one
  • AKOS BBS-00003131
  • IFLAB-BB F1371-0159
  • NSC 4948
  • 9H-Purine, 6-chloro-9-methyl-
  • 2346-74-9
  • pharmacetical
  • Nucleotides and Nucleosides
  • Bases & Related Reagents
  • Nucleotides