ChemicalBook > CAS DataBase List > 6-CHLORO-7-METHYLPURINE

6-CHLORO-7-METHYLPURINE

Product Name
6-CHLORO-7-METHYLPURINE
CAS No.
5440-17-5
Chemical Name
6-CHLORO-7-METHYLPURINE
Synonyms
NSC 15192;7-METHYL-6-CHLOROPURINE;6-CHLORO-7-METHYLPURINE;6-Chloro-7-methyl-7H-purine;7H-Purine, 6-chloro-7-methyl-
CBNumber
CB1429820
Molecular Formula
C6H5ClN4
Formula Weight
168.58
MOL File
5440-17-5.mol
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6-CHLORO-7-METHYLPURINE Property

Melting point:
175-185°C
Boiling point:
321.7±45.0 °C(Predicted)
Density 
1.59±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
solubility 
Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly)
form 
Solid
pka
0.65±0.30(Predicted)
color 
Light Green to Grey-Blue
CAS DataBase Reference
5440-17-5
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C369495
Product name
6-Chloro-7-methylpurine
Packaging
50mg
Price
$120
Updated
2021/12/16
Usbiological
Product number
C5028-60
Product name
6-Chloro-7-methylpurine
Packaging
25mg
Price
$389
Updated
2021/12/16
TRC
Product number
C369495
Product name
6-Chloro-7-methylpurine
Packaging
500mg
Price
$645
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-5-AR
Product name
6-Chloro-7-methyl-7H-purine
Packaging
500mg
Price
$1112
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC09543
Product name
6-Chloro-7-methylpurine
Packaging
250mg
Price
$400
Updated
2021/12/16
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6-CHLORO-7-METHYLPURINE Chemical Properties,Usage,Production

Chemical Properties

Light Green Solid

Uses

6-CHLORO-7-METHYLPURINE is a useful synthetic intermediate.

Synthesis

87-42-3

74-88-4

5440-17-5

To a 1L three-necked round-bottomed flask was added 6-chloro-9H-purine (15.4 g, 0.1 mol, 1 eq.) and tetrahydrofuran (155 mL) at 0 °C and protected by nitrogen in an inert atmosphere. Methylmagnesium chloride (MeMgCl, 36.6 mL, 1.0 M THF solution, 1.1 eq.) was added dropwise with stirring. The reaction mixture was continued to be stirred at 0 °C for 30 min. Subsequently, iodomethane (42.6 g, 3 eq.) was added slowly and dropwise with stirring. The resulting reaction solution was transferred to a 50 °C oil bath and the reaction was stirred for 5 hours. Upon completion of the reaction, the reaction was quenched by addition of 50 mL of aqueous ammonium chloride (NH4Cl) and extracted with dichloromethane (3 x 50 mL). The organic layers were combined and washed with brine (2 x 50 mL) and subsequently concentrated under vacuum. The crude product was recrystallized by dichloromethane/petroleum ether (1:10) to afford 6-chloro-7-methylpurine as a light green solid (7 g, 42% yield).

References

[1] Organic Letters, 2016, vol. 18, # 1, p. 16 - 19
[2] Patent: WO2018/96159, 2018, A1. Location in patent: Paragraph 0169-0172

6-CHLORO-7-METHYLPURINE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-CHLORO-7-METHYLPURINE Suppliers

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View Lastest Price from 6-CHLORO-7-METHYLPURINE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
6-CHLORO-7-METHYLPURINE 5440-17-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
6-CHLORO-7-METHYLPURINE 5440-17-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Career Henan Chemical Co
Product
6-CHLORO-7-METHYLPURINE 5440-17-5
Price
US $1.00/KG
Min. Order
1KG
Purity
95%-99.99%
Supply Ability
1kg-10MT
Release date
2019-05-24

5440-17-5, 6-CHLORO-7-METHYLPURINERelated Search:

6-chloro-5-Methylpyridazin-3-aMine 6-Chloro-4-methylpyridazin-3-amine 6-Chloropurine 2-METHYLTHIO-6-CHLORO-9-METHYLPURINE 97% (HPLC) 6-CHLORO-9-METHYLPURINE 6-AMINO-2-CHLORO-7-METHYLPURINE 2-AMINO-6-CHLORO-7-ISOPROPYLPURINE 6-CHLORO-7-METHYLPURINE 6-CHLORO-2,8-DIMETHYL-7-(PHENYLMETHYL)-7H-PURINE 2-AMINO-6-CHLORO-7-(2,3-DIDEOXY-3-FLUORO-5-O(4-PHENYLBENZOYL)-BETA-D-ERYTHROPENTOFURANOSYL)-7H-PURINE 6-CHLORO-7-BENZYLPURINE 2,6,8-TRICHLORO-7-METHYLPURINE 4-CHLORO-7,8-DIHYDRO-6H-PYRROLO[2,1-F]PURINE 2,6-Dichloro-7-methylpurine 4-CHLORO-6,7,8,9-TETRAHYDROPYRIDO[2,1-F]PURINE

  • 6-CHLORO-7-METHYLPURINE
  • 7-METHYL-6-CHLOROPURINE
  • NSC 15192
  • 6-Chloro-7-methyl-7H-purine
  • 7H-Purine, 6-chloro-7-methyl-
  • 5440-17-5
  • Bases & Related Reagents
  • Nucleotides