Acetylpyrazine
- Product Name
- Acetylpyrazine
- CAS No.
- 22047-25-2
- Chemical Name
- Acetylpyrazine
- Synonyms
- 2-ACETYLPYRAZINE;1-pyrazinylethanone;FEMA 3126;1-PYRAZIN-2-YL-ETHANONE;9H-1;2-Acetyl;ACETYLPYRAZINE;FEMA NUMBER 3126;ACETYL-2-PYRAZIN;Diacetylpyrazine
- CBNumber
- CB1254200
- Molecular Formula
- C6H6N2O
- Formula Weight
- 122.12
- MOL File
- 22047-25-2.mol
Acetylpyrazine Property
- Melting point:
- 76-78 °C (lit.)
- Boiling point:
- 78-79°C 8mm
- Density
- 1.1075
- refractive index
- 1.5350 (estimate)
- FEMA
- 3126 | ACETYLPYRAZINE
- Flash point:
- 78-79°C/8mm
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 0.30±0.10(Predicted)
- color
- White to Off-White
- Odor
- popcorn-like odor
- Odor Type
- popcorn
- JECFA Number
- 784
- BRN
- 109630
- InChIKey
- DBZAKQWXICEWNW-UHFFFAOYSA-N
- LogP
- 0.20
- CAS DataBase Reference
- 22047-25-2(CAS DataBase Reference)
- NIST Chemistry Reference
- Acetylpyrazine(22047-25-2)
- EPA Substance Registry System
- Ethanone, 1-pyrazinyl- (22047-25-2)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-24/25
- WGK Germany
- 2
- TSCA
- T
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- W312606
- Product name
- 2-Acetylpyrazine
- Purity
- ≥99%, FCC, FG
- Packaging
- 100g
- Price
- $124
- Updated
- 2024/03/01
- Product number
- W312606
- Product name
- 2-Acetylpyrazine
- Purity
- ≥99%, FCC, FG
- Packaging
- 1kg
- Price
- $563
- Updated
- 2024/03/01
- Product number
- W312606
- Product name
- 2-Acetylpyrazine
- Purity
- ≥99%, FCC, FG
- Packaging
- 5kg
- Price
- $2350
- Updated
- 2024/03/01
- Product number
- 251801
- Product name
- Acetylpyrazine
- Purity
- 97%
- Packaging
- 1g
- Price
- $15
- Updated
- 2024/03/01
- Product number
- 251801
- Product name
- Acetylpyrazine
- Purity
- 97%
- Packaging
- 5g
- Price
- $26
- Updated
- 2024/03/01
Acetylpyrazine Chemical Properties,Usage,Production
Description
2-acetylpyrazine is white to pale yellow crystalline powder with a nutty, popcorn, bread-crust odor. It is soluble in water and stable under ordinary conditions. It is used to manufacture many polycyclic compounds and used as useful structures in pharmaceuticals and perfumes. It is a component of the folates (vitamin B compounds) and of the isoalloxazine ring nucleus of flavins. Numerous pyrazine derivatives such as pyrazine polycyclic compounds, alkyl-, alicyclic-, and alkylaryl-substituted compounds, derivatives containing oxygenated functional groups and thio-functional groups in the side-chains are used in biological, drug, flavoring and perfumery industry. 2-acetylpyrazine is used as food additive, commonly used in chocolate and baked goods.
Chemical Properties
Acetylpyrazine is a light yellow to yellow-brownish powder that has a nutty, popcorn, bread crust odor. It is one of the volatile aroma components in popcorn, wheat and rye crusts.
Occurrence
Reported found in guava fruit (Psidium guajava L.), wheaten bread, other types of breads, boiled and cooked beef, grilled/roasted uncured pork, pork liver, cocoa, coffee, black tea, roasted barley, roasted filbert (Corylus avellano), roasted peanut (Arachis hypogea), roasted almond (Prunus amygdalus), scallop, filberts, popcorn and sesame oil.
Uses
Acetylpyrazine has been used in synthesis of:
7-heteroaryl-pyrazolo[1,5-a]pyrimidine-3-carboxamides
copper (II) complexes with di-imine ligands
N(4) substituted thiosemicarbazones
Preparation
synthesis of acetylpyrazine: By the ester condensation of EtO2 C-pyrazine; by dehydrating pyrazynamide with POCI3 and then reacting the resulting 2-cyano-pyrazine with methyl magnesium bromide.
Definition
ChEBI: 2-acetylpyrazine is a pyrazine that is substituted by an acetyl group at position 2. It has been identified as one of the volatile flavor constituents in popcorn, bread crust, vinegar, and potato snacks. It has a role as a flavouring agent. It is an aromatic ketone and a member of pyrazines.
Application
Acetylpyrazine has been widely used as an intermediate in the organic synthesis of various heterocyclic derivatives and in coupling reactions, alkylation reactions, and sensitizer ligands because of its good biological and reactive activities. For example, it is a significant reaction intermediate for producing drugs for treating malaria, epilepsy, and Parkinson's disease.
Aroma threshold values
Detection at 62 ppb
Taste threshold values
Taste characteristics at 10 ppm: roasted, nutty, bready, yeasty with popcorn, corn chip nuance
General Description
2-Acetylpyrazine has been identified as one of the volatile flavor constituents in popcorn, wheat and rye bread crust.
References
[1] CHAO-RUI LI. Study on 2-Acetylpyrazine (pyridine-2?-acetyl) hydrazone as a fluorescent sensor for Al3+[J]. Journal of Luminescence, 2015, 168: Pages 330-333. DOI:10.1016/j.jlumin.2015.07.055.
[2] RAMAIYER VENKATRAMAN. Structures of Eight Thio(semi)carbazones Derived from 2-Acetylpyrazine, 2-Acetythiazole and Acetophenone[J]. Journal of Chemical Crystallography, 2009, 39 10. DOI:10.1007/s10870-009-9541-0.
[3] LIN MAO. Electrochemical Synthesis of Acetylpyrazine[J]. Journal of Electrochemistry, 2021, 9 1: 0. DOI:10.13208/J.ELECTROCHEM.210706.
[4] https://pubchem.ncbi.nlm.nih.gov/compound/Acetylpyrazine#section=Pharmacology-and-Biochemistry
[5] https://en.wikipedia.org/wiki/Acetylpyrazine
[6] http://www.chemicalland21.com/specialtychem/perchem/2-ACETYLPYRAZINE.htm
Acetylpyrazine Preparation Products And Raw materials
Raw materials
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View Lastest Price from Acetylpyrazine manufacturers
- Product
- Acetylpyrazine 22047-25-2
- Price
- US $33.00-1.20/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-26
- Product
- Acetylpyrazine 22047-25-2
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99.10%
- Supply Ability
- 5000kg
- Release date
- 2024-04-17
- Product
- acetylpyrazine 22047-25-2
- Price
- US $65.00-45.00/kg
- Min. Order
- 500kg
- Purity
- 99.9
- Supply Ability
- 200tons
- Release date
- 2024-03-12