Methyl 2-broMo-4-chlorobenzoate
- Product Name
- Methyl 2-broMo-4-chlorobenzoate
- CAS No.
- 57381-62-1
- Chemical Name
- Methyl 2-broMo-4-chlorobenzoate
- Synonyms
- Methyl 2-broMo-4-chlorobenzoate;Methyl 2-bormo-4-chlorobenzoate;Benzoic acid, 2-broMo-4-chloro-, Methyl ester
- CBNumber
- CB12550360
- Molecular Formula
- C8H6BrClO2
- Formula Weight
- 249.49
- MOL File
- 57381-62-1.mol
Methyl 2-broMo-4-chlorobenzoate Property
- Boiling point:
- 268.8±20.0 °C(Predicted)
- Density
- 1.604±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- clear liquid
- color
- Colorless to Light yellow
- InChI
- InChI=1S/C8H6BrClO2/c1-12-8(11)6-3-2-5(10)4-7(6)9/h2-4H,1H3
- InChIKey
- BIFARHLBYAKSSN-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C1=CC=C(Cl)C=C1Br
Safety
- HS Code
- 2916310090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- M3131
- Product name
- Methyl 2-Bromo-4-chlorobenzoate
- Packaging
- 5G
- Price
- $55
- Updated
- 2025/07/31
- Product number
- M3131
- Product name
- Methyl 2-Bromo-4-chlorobenzoate
- Packaging
- 25G
- Price
- $200
- Updated
- 2025/07/31
- Product number
- M293838
- Product name
- Methyl 2-Bromo-4-chlorobenzoate
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 215654
- Product name
- Methyl 2-bromo-4-chlorobenzoate
- Packaging
- 5g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- OR400102
- Product name
- Methyl 2-Bromo-4-chlorobenzoate
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
Methyl 2-broMo-4-chlorobenzoate Chemical Properties,Usage,Production
Chemical Properties
Pale yellow liquid
Uses
Methyl 2-broMo-4-chlorobenzoate is a carboxylic acid ester organic compound used in organic synthesis reactions.
Synthesis
67-56-1
936-08-3
57381-62-1
Step 1: Synthesis of methyl 2-bromo-4-chlorobenzoate. Thionyl chloride (29.2 mL, 400 mmol) was slowly added dropwise to a 500 mL two-necked round-bottomed flask containing 300 mL of anhydrous methanol at 0-5 °C (ice-water bath) for a controlled time of 10 min. After removing the ice water bath, 2-bromo-4-chlorobenzoic acid (25 g, 106 mmol) was added. The reaction mixture was heated to gentle reflux and maintained for 12 hours. The reaction progress was monitored by thin layer chromatography (TLC) and liquid chromatography-mass spectrometry (LCMS). After completion of the reaction, the reaction mixture was concentrated. The crude product was dissolved in 250 mL of dichloromethane (DCM) and washed sequentially with 50 mL of water, 50 mL of saturated aqueous sodium bicarbonate solution and 50 mL of brine. The organic phase was dried over anhydrous sodium sulfate and concentrated to afford methyl 2-bromo-4-chlorobenzoate (26 g, 99% yield), and the product was used directly in subsequent steps without further purification.
References
[1] Patent: US2008/153852, 2008, A1. Location in patent: Page/Page column 19
[2] Patent: CN104045626, 2017, B. Location in patent: Paragraph 0227
[3] Patent: WO2010/55005, 2010, A1. Location in patent: Page/Page column 71
[4] Journal of the American Chemical Society, 2016, vol. 138, # 18, p. 5813 - 5816
Methyl 2-broMo-4-chlorobenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 2-broMo-4-chlorobenzoate manufacturers
- Product
- Methyl 2-bromo-4-chlorobenzoate 57381-62-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 2000kg
- Release date
- 2023-06-09
- Product
- Methyl 2-broMo-4-chlorobenzoate 57381-62-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-08-09