WYE-687

ChemicalBook > CAS DataBase List > WYE-687

Product Name: WYE-687
CAS No.: 1062161-90-3
Chemical Name: WYE-687
Synonyms: CS-540;WYE-687;L-Leucine-d;WYE-687 WYE687;WYE-687 USP/EP/BP;WYE-687;WYE 687;WYE687;17α-Ethynyltestosterone;methyl 4-(4-morpholino-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenylcarbamate;methyl N-[4-[4-morpholin-4-yl-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]carbamate;N-[4-[4-(4-Morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]carbamic acid methyl ester
CBNumber: CB12561502
Molecular Formula: C28H32N8O3
Formula Weight: 528.61
MOL File: 1062161-90-3.mol

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WYE-687 Property

Density: 1.40
storage temp.: Store at -20°C
solubility: insoluble in H2O; insoluble in EtOH; insoluble in DMSO
form: Powder
pka: 13.42±0.70(Predicted)
color: Off-white to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3375
Product name: WYE-687
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $81.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML3375
Product name: WYE-687
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $327
Updated: 2024/03/01

Cayman Chemical

Product number: 29977
Product name: WYE-687
Packaging: 1mg
Price: $48
Updated: 2024/03/01

Cayman Chemical

Product number: 29977
Product name: WYE-687
Packaging: 25mg
Price: $636
Updated: 2024/03/01

Cayman Chemical

Product number: 29977
Product name: WYE-687
Packaging: 5mg
Price: $152
Updated: 2024/03/01

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WYE-687 Chemical Properties,Usage,Production

Uses

WYE-687 is an ATP-competitive and selective inhibitor of mammalian target of rapamycin (mTOR). Studies have shown the combination of Ras-Raf-MEK1/2 inhibitors with WYE-687 may overcome resistance to mTorKIs thus may be an effective additive therapy for treatment of patient with renal cell carcinoma or colorectal cancer.

Biological Activity

wye-687 is an atp-competitive inhibitor of mtor with ic50 value of 7nm [1].wye-687 is a small-molecule pyrazolopyrimidine inhibitor of mtor1 and mtor2. in the immune-complex kinase assay using his6-akt and his6-s6k as the specific substrates of mtor1 and mtor2, wye-687 prevents mtor from phosphorylating the substrates dose-dependently. besides that, wye-687 is found to highly selective against pi3kα (>100-fold) and pi3kγ (>500-fold) as well as 24 other protein kinases. it is found that wye-687 can suppress cell growth via causing a strong g1 arrest in cell cycle in tumor cell lines including mda361 and hct116. wye-687 also affects the angiogenic factor of cancer cells. it reduces the expression of hif-1α in u87mg, mda361 and lncap cells [1].

References

[1] yu k, toral-barza l, shi c, et al. biochemical, cellular, and in vivo activity of novel atp-competitive and selective inhibitors of the mammalian target of rapamycin. cancer research, 2009, 69(15): 6232-6240.

WYE-687 Preparation Products And Raw materials

Raw materials

Preparation Products

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1062161-90-3, WYE-687Related Search:

WYE 354-d3 N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methylurea WYE-354 MK-2206 2HCl CX-4945 PaloMid 529 (P529) Trametinib GSK429286A Rapamycin

methyl 4-(4-morpholino-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenylcarbamate

methyl N-[4-[4-morpholin-4-yl-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]carbamate

WYE-687;WYE 687;WYE687

WYE-687

N-[4-[4-(4-Morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]carbamic acid methyl ester

N-[4-[4-(4-Morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-carbamic acid methyl ester hydrochloride

CS-540

Carbamic acid, N-[4-[4-(4-morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-, methyl ester

WYE-687 USP/EP/BP

17α-Ethynyltestosterone

WYE-687 WYE687

L-Leucine-d

1062161-90-3

C28H32N8O3

Inhibitors

Akt

PI3K/Akt/mTOR

mTOR

PI3K