WYE-687
- Product Name
- WYE-687
- CAS No.
- 1062161-90-3
- Chemical Name
- WYE-687
- Synonyms
- CS-540;WYE-687;L-Leucine-d;WYE-687 WYE687;WYE-687 USP/EP/BP;WYE-687;WYE 687;WYE687;17α-Ethynyltestosterone;methyl 4-(4-morpholino-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenylcarbamate;methyl N-[4-[4-morpholin-4-yl-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]carbamate;N-[4-[4-(4-Morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]carbamic acid methyl ester
- CBNumber
- CB12561502
- Molecular Formula
- C28H32N8O3
- Formula Weight
- 528.61
- MOL File
- 1062161-90-3.mol
WYE-687 Property
- Density
- 1.40
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; insoluble in EtOH; insoluble in DMSO
- form
- Powder
- pka
- 13.42±0.70(Predicted)
- color
- Off-white to yellow
N-Bromosuccinimide Price
- Product number
- SML3375
- Product name
- WYE-687
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $81.2
- Updated
- 2024/03/01
- Product number
- SML3375
- Product name
- WYE-687
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $327
- Updated
- 2024/03/01
- Product number
- 29977
- Product name
- WYE-687
- Packaging
- 1mg
- Price
- $48
- Updated
- 2024/03/01
- Product number
- 29977
- Product name
- WYE-687
- Packaging
- 25mg
- Price
- $636
- Updated
- 2024/03/01
- Product number
- 29977
- Product name
- WYE-687
- Packaging
- 5mg
- Price
- $152
- Updated
- 2024/03/01
WYE-687 Chemical Properties,Usage,Production
Uses
WYE-687 is an ATP-competitive and selective inhibitor of mammalian target of rapamycin (mTOR). Studies have shown the combination of Ras-Raf-MEK1/2 inhibitors with WYE-687 may overcome resistance to mTorKIs thus may be an effective additive therapy for treatment of patient with renal cell carcinoma or colorectal cancer.
Biological Activity
wye-687 is an atp-competitive inhibitor of mtor with ic50 value of 7nm [1].wye-687 is a small-molecule pyrazolopyrimidine inhibitor of mtor1 and mtor2. in the immune-complex kinase assay using his6-akt and his6-s6k as the specific substrates of mtor1 and mtor2, wye-687 prevents mtor from phosphorylating the substrates dose-dependently. besides that, wye-687 is found to highly selective against pi3kα (>100-fold) and pi3kγ (>500-fold) as well as 24 other protein kinases. it is found that wye-687 can suppress cell growth via causing a strong g1 arrest in cell cycle in tumor cell lines including mda361 and hct116. wye-687 also affects the angiogenic factor of cancer cells. it reduces the expression of hif-1α in u87mg, mda361 and lncap cells [1].
References
[1] yu k, toral-barza l, shi c, et al. biochemical, cellular, and in vivo activity of novel atp-competitive and selective inhibitors of the mammalian target of rapamycin. cancer research, 2009, 69(15): 6232-6240.