ARRY-334543
- Product Name
- ARRY-334543
- CAS No.
- 845272-21-1
- Chemical Name
- ARRY-334543
- Synonyms
- CS-663;ASLAN001);Varlitinib;AR-00334543;ARRY-334543;Varlitinib (ARRY-543);Varlitinib Ditosylate;ARRY-334543 USP/EP/BP;ARRY-334543;ARRY334543;ARRY 334543 (Varlitinib)
- CBNumber
- CB12582909
- Molecular Formula
- C22H19ClN6O2S
- Formula Weight
- 466.94
- MOL File
- 845272-21-1.mol
ARRY-334543 Property
- Boiling point:
- 637.1±65.0 °C(Predicted)
- Density
- 1.51±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 50 mg/mL (107.08 mM; Need ultrasonic)
- form
- Powder
- pka
- 6.54±0.70(Predicted)
- color
- Off-white to yellow
- CAS DataBase Reference
- 845272-21-1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
H335May cause respiratory irritation
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 27651
- Product name
- Varlitinib
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 27651
- Product name
- Varlitinib
- Packaging
- 25mg
- Price
- $745
- Updated
- 2024/03/01
- Product number
- 27651
- Product name
- Varlitinib
- Packaging
- 5mg
- Price
- $183
- Updated
- 2024/03/01
- Product number
- 27651
- Product name
- Varlitinib
- Packaging
- 10mg
- Price
- $341
- Updated
- 2024/03/01
- Product number
- V099100
- Product name
- Varlitinib
- Packaging
- 10mg
- Price
- $370
- Updated
- 2021/12/16
ARRY-334543 Chemical Properties,Usage,Production
Uses
ARRY334543 is a selective and potent ErbB1 and ErbB2 inhibitor with IC50 of 7 nM and 2 nM, respectively.
Enzyme inhibitor
This ErbB1/2 inhibitor (FW = 466.94 g/mol; CAS 845272-21-1), also named (R)-N4 -(3-chloro-4-(thiazol-2-ylmethoxy)phenyl)-N6 -(4-methyl-4,5- dihydrooxazol-2-yl)quinazoline-4,6-diamine, selectively targets the intrinsic protein kinase activities of ErbB1, or Epidermal Growth Factor Receptor (EGFR), IC50 = 7 nM and ErbB2, or Human Epidermal growth factor Receptor (HER2), IC50 = 2 nM. ARRY-334543 also reverses multidrug resistance by antagonizing the activity of ATP-binding cassette subfamily G member 2.
target
ErbB2
ARRY-334543 Preparation Products And Raw materials
Raw materials
Preparation Products
ARRY-334543 Suppliers
- Tel
- 44-20819178-90 02081917890
- Fax
- (0)2080432064
- info@novachemistry.com
- Country
- United Kingdom
- ProdList
- 4381
- Advantage
- 58
View Lastest Price from ARRY-334543 manufacturers
- Product
- Varlitinib 845272-21-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13