(2-Aminophenyl)dimethylphosphine Oxide
- Product Name
- (2-Aminophenyl)dimethylphosphine Oxide
- CAS No.
- 1197953-47-1
- Chemical Name
- (2-Aminophenyl)dimethylphosphine Oxide
- Synonyms
- Buglitinibintermediate;2-(Dimethyloxonyl)aniline;Brigatinib intermediates;2-(Dimethylphosphinyl)aniline;2-(diMethylphosphoryl)aniline;2- (dimethylphosphino) aniline;2-(diMethylphosphoryl)aniline HCl;2-(diMethylphosphoryl)benzenaMine;2-(Dimethylphosphinyl)benzenamine;3-(Dimethylphosphinyl)benzenamine
- CBNumber
- CB12595392
- Molecular Formula
- C8H12NOP
- Formula Weight
- 169.16
- MOL File
- 1197953-47-1.mol
(2-Aminophenyl)dimethylphosphine Oxide Property
- Boiling point:
- 367.5±34.0 °C(Predicted)
- Density
- 1.11±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 1.10±0.10(Predicted)
- InChI
- InChI=1S/C8H12NOP/c1-11(2,10)8-6-4-3-5-7(8)9/h3-6H,9H2,1-2H3
- InChIKey
- DHHGHQKIKXKQGJ-UHFFFAOYSA-N
- SMILES
- C1(N)=CC=CC=C1P(C)(C)=O
Safety
- RIDADR
- UN2811
- HS Code
- 2923900090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A638018
- Product name
- (2-Aminophenyl)dimethylphosphineOxide
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- A638018
- Product name
- (2-Aminophenyl)dimethylphosphineOxide
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- Z3963
- Product name
- (2-Aminophenyl)dimethylphosphineoxide
- Packaging
- 1g
- Price
- $134
- Updated
- 2021/12/16
- Product number
- OR49045
- Product name
- 2-Dimethylphosphorylaniline
- Packaging
- 1g
- Price
- $169
- Updated
- 2021/12/16
- Product number
- Z3963
- Product name
- (2-Aminophenyl)dimethylphosphineoxide
- Packaging
- 5g
- Price
- $289
- Updated
- 2021/12/16
(2-Aminophenyl)dimethylphosphine Oxide Chemical Properties,Usage,Production
Uses
(2-Aminophenyl)dimethylphosphine Oxide is mainly used as a raw material or reagent for organic synthesis and can be used to prepare other compounds such as phosphine oxide derivatives and pyrimidine derivatives.
Synthesis
(2-Aminophenyl)dimethylphosphine Oxide is prepared by the reaction of 2-Iodoaniline and Dimethylphosphine oxide. The specific synthesis steps are as follows:
To a solution of 2-iodoaniline ( 1.0 eq) and dimethylphosphine oxide (1.1 eq) in DMF were added potassium phosphate ( 1.1 eq) and palladium acetate/Xantphos (catalytic). The reaction was stirred at 150 °C for 3 hours and cooled to room temperature. The solvent was evaporated and the residue was worked up with DCM/water. The crude product was purified with a column(EtOAc/MeOH 10: 1 ) to give 1 as a brown solid (80percent yield).
(2-Aminophenyl)dimethylphosphine Oxide Preparation Products And Raw materials
Raw materials
Preparation Products
(2-Aminophenyl)dimethylphosphine Oxide Suppliers
- Tel
- --
- Fax
- --
- enquiries@fluorochem.co.uk
- Country
- United Kingdom
- ProdList
- 6401
- Advantage
- 74
View Lastest Price from (2-Aminophenyl)dimethylphosphine Oxide manufacturers
- Product
- 2-(diMethylphosphoryl)aniline 1197953-47-1
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-09
- Product
- 2-(diMethylphosphoryl)aniline 1197953-47-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-08
- Product
- 2-(diMethylphosphoryl)aniline 1197953-47-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10