ChemicalBook > CAS DataBase List > 5-aMino-2-broMo-4-Methylbenzoic acid Methyl ester
5-aMino-2-broMo-4-Methylbenzoic acid Methyl ester
- Product Name
- 5-aMino-2-broMo-4-Methylbenzoic acid Methyl ester
- CAS No.
- 474330-54-6
- Chemical Name
- 5-aMino-2-broMo-4-Methylbenzoic acid Methyl ester
- Synonyms
- Methyl 5-aMino-2-broMo-4-Methylbenzoate;5-aMino-2-broMo-4-Methylbenzoic acid Methyl ester;methyl 5-amino-2-bromo-4-methylbenzoate hydrochloride;Benzoic acid, 5-aMino-2-broMo-4-Methyl-, Methyl ester
- CBNumber
- CB12609963
- Molecular Formula
- C9H10BrNO2
- Formula Weight
- 244.09
- MOL File
- 474330-54-6.mol
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5-aMino-2-broMo-4-Methylbenzoic acid Methyl ester Property
- Boiling point:
- 328.4±37.0 °C(Predicted)
- Density
- 1.506±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 2.60±0.10(Predicted)
- Appearance
- Light brown to gray Solid
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N-Bromosuccinimide Price
AK Scientific
- Product number
- 7107AJ
- Product name
- Methyl5-amino-2-bromo-4-methylbenzoate
- Packaging
- 250mg
- Price
- $147
- Updated
- 2021/12/16
SynChem
- Product number
- SC-25750
- Product name
- 5-Amino-2-bromo-4-methylbenzoic acid methyl ester
- Purity
- 95%
- Packaging
- 5G
- Price
- $265
- Updated
- 2021/12/16
Chemenu
- Product number
- CM253109
- Product name
- Methyl5-amino-2-bromo-4-methylbenzoate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $266
- Updated
- 2021/12/16
Ambeed
- Product number
- A308556
- Product name
- Methyl5-amino-2-bromo-4-methylbenzoate
- Purity
- 97%
- Packaging
- 5g
- Price
- $282
- Updated
- 2021/12/16
Crysdot
- Product number
- CD12069966
- Product name
- Methyl5-amino-2-bromo-4-methylbenzoate
- Purity
- 97%
- Packaging
- 5g
- Price
- $282
- Updated
- 2021/12/16
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5-aMino-2-broMo-4-Methylbenzoic acid Methyl ester Chemical Properties,Usage,Production
Synthesis
67-56-1
745048-63-9
474330-54-6
General procedure for the synthesis of methyl 5-amino-2-bromo-4-methylbenzoate from methanol and 5-amino-2-bromo-4-methylbenzoic acid: 5-amino-2-bromo-4-methylbenzoic acid (39.90 g, 0.17 mol) was suspended in methanol (500 mL). The suspension was cooled to 0 to 5 °C and thionyl chloride (40 mL, 0.54 mol) was added slowly and dropwise. The reaction mixture was heated to reflux for 6 hours. Upon completion of the reaction, the solution was concentrated under reduced pressure and the residue was diluted with ice water (500 g). The pH was adjusted to 7.5 with saturated aqueous sodium bicarbonate and subsequently extracted with ethyl acetate (3 x 200 mL). The organic phases were combined, washed with saturated saline (3 x 200 mL), dried over anhydrous magnesium sulfate, filtered and concentrated to dryness under reduced pressure to afford methyl 5-amino-2-bromo-4-methylbenzoate as a white solid (40.35 g, 95% yield).
References
[1] Patent: US2007/275907, 2007, A1. Location in patent: Page/Page column 19
[2] Patent: US2008/242596, 2008, A1. Location in patent: Page/Page column 15
[3] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 19, p. 5632 - 5635
[4] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 24, p. 6877 - 6881
[5] ChemMedChem, 2010, vol. 5, # 6, p. 827 - 831
5-aMino-2-broMo-4-Methylbenzoic acid Methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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