Methyl-5-amino-2-chlorobenzoate

Product Name: Methyl-5-amino-2-chlorobenzoate
CAS No.: 42122-75-8
Chemical Name: Methyl-5-amino-2-chlorobenzoate
Synonyms: TIMTEC-BB SBB013130;OTAVA-BB 7020693933;METHYL 2-CHLORO-5-AMINOBENZOATE;Methyl 3-amino-6-chlorobenzoate;Methyl-5-amino-2-chlorobenzoate;Methyl 2-chloro-5-aminobenzoate 95+%;5-Amino-2-chlorobenzoic acid methyl ester;2-Chloro-5-aMinobenzoic acid Methyl ester;BENZOIC ACID, 5-AMINO-2-CHLORO-, METHYL ESTER;methyl 5-amino-2-chlorobenzoate(SALTDATA: HCl)
CBNumber: CB41115000
Molecular Formula: C8H8ClNO2
Formula Weight: 185.61
MOL File: 42122-75-8.mol

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Methyl-5-amino-2-chlorobenzoate Property

Melting point:: 68-70℃
Boiling point:: 320℃
Density: 1.311
Flash point:: 147℃
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: soluble in Methanol
form: powder to lump
pka: 2.81±0.10(Predicted)
color: White to Yellow to Orange
InChI: InChI=1S/C8H8ClNO2/c1-12-8(11)6-4-5(10)2-3-7(6)9/h2-4H,10H2,1H3
InChIKey: LBNPBOFVHYOPIB-UHFFFAOYSA-N
SMILES: C(OC)(=O)C1=CC(N)=CC=C1Cl

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Safety

HS Code: 2916399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M2812
Product name: Methyl 5-Amino-2-chlorobenzoate
Purity: >98.0%(T)
Packaging: 1g
Price: $25
Updated: 2025/07/31

TCI Chemical

Product number: M2812
Product name: Methyl 5-Amino-2-chlorobenzoate
Purity: >98.0%(T)
Packaging: 5g
Price: $74
Updated: 2025/07/31

TRC

Product number: M328660
Product name: Methyl 5-Amino-2-chlorobenzoate
Packaging: 500mg
Price: $65
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4658-5-01
Product name: Methyl 5-amino-2-chlorobenzoate
Packaging: 1g
Price: $16
Updated: 2021/12/16

AK Scientific

Product number: J50898
Product name: Methyl 5-Amino-2-chlorobenzoate
Packaging: 5g
Price: $39
Updated: 2021/12/16

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Methyl-5-amino-2-chlorobenzoate Chemical Properties,Usage,Production

Chemical Properties

Pale yellow crystal

Uses

Methyl 5-amino-2-chlorobenzoate

Synthesis

67-56-1

89-54-3

42122-75-8

The general procedure for the synthesis of methyl 2-chloro-5-aminobenzoate from methanol and 5-amino-2-chlorobenzoic acid was as follows: to a stirred solution of 5-amino-2-chlorobenzoic acid (50 g, 291 mmol) in methanol (300 mL) was added chloromethane (45 mL, 605 mmol) dropwise at 0 °C. The reaction mixture was refluxed for 12 hours and then cooled to room temperature. Subsequently, the reaction mixture was concentrated under vacuum and the residue was dissolved in ethyl acetate (500 mL), washed with saturated aqueous sodium bicarbonate (3 x 100 mL), dried over anhydrous sodium sulfate and concentrated again under vacuum to give methyl 5-amino-2-chlorobenzoate as a light white solid (54 g, quantitative yield).LC/MS analysis: m/e Calculated value C8H8ClNO2 (M +H)+: 186.61, measured value: 185.9.

References

[1] Patent: WO2011/128251, 2011, A1. Location in patent: Page/Page column 180-181
[2] Patent: US2011/257151, 2011, A1. Location in patent: Page/Page column 67
[3] Patent: WO2007/60026, 2007, A1. Location in patent: Page/Page column 48-49
[4] Patent: EP1746099, 2007, A1. Location in patent: Page/Page column 18-19
[5] Journal of Medicinal Chemistry, 2009, vol. 52, # 8, p. 2465 - 2481

Methyl-5-amino-2-chlorobenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl-5-amino-2-chlorobenzoate Suppliers

Americas 1 China 87 Europe 1 India 9 Japan 1 Switzerland 1 United Kingdom 3 United States 14 Global 117

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View Lastest Price from Methyl-5-amino-2-chlorobenzoate manufacturers

Career Henan Chemical Co

Product: Methyl-5-amino-2-chlorobenzoate 42122-75-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-11

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Methyl-5-amino-2-chlorobenzoate

BENZOIC ACID, 5-AMINO-2-CHLORO-, METHYL ESTER

METHYL 2-CHLORO-5-AMINOBENZOATE

OTAVA-BB 7020693933

TIMTEC-BB SBB013130

methyl 5-amino-2-chlorobenzoate(SALTDATA: HCl)

2-Chloro-5-aMinobenzoic acid Methyl ester

5-Amino-2-chlorobenzoic acid methyl ester

Methyl 3-amino-6-chlorobenzoate

Methyl 2-chloro-5-aminobenzoate 95+%

42122-75-8