5-AMINO-2-BROMO-BENZOIC ACID METHYL ESTER
- Product Name
- 5-AMINO-2-BROMO-BENZOIC ACID METHYL ESTER
- CAS No.
- 6942-37-6
- Chemical Name
- 5-AMINO-2-BROMO-BENZOIC ACID METHYL ESTER
- Synonyms
- NSC 57463;Methyl 5-aMino-2-broMobenzoate;Methyl 5-amino-2-bromobenzoate 98%;2-broMo-5-aMinobenzoic acid Methyl ester;5-AMINO-2-BROMO-BENZOIC ACID METHYL ESTER;Benzoic acid, 5-amino-2-bromo-, methyl ester
- CBNumber
- CB9283637
- Molecular Formula
- C8H8BrNO2
- Formula Weight
- 230.06
- MOL File
- 6942-37-6.mol
5-AMINO-2-BROMO-BENZOIC ACID METHYL ESTER Property
- Boiling point:
- 313.2±22.0 °C(Predicted)
- Density
- 1.578±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 2.75±0.10(Predicted)
- form
- liquid
- color
- Clear, brown to very dark red
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- M286590
- Product name
- methyl5-amino-2-bromobenzoate
- Packaging
- 250mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- M286590
- Product name
- methyl5-amino-2-bromobenzoate
- Packaging
- 1g
- Price
- $295
- Updated
- 2021/12/16
- Product number
- OR55136
- Product name
- Methyl5-amino-2-bromobenzoate
- Purity
- 98%
- Packaging
- 25g
- Price
- $427
- Updated
- 2021/12/16
- Product number
- 4658-9-26
- Product name
- Methyl 5-amino-2-bromobenzoate
- Purity
- 98%
- Packaging
- 25g
- Price
- $471
- Updated
- 2021/12/16
- Product number
- HCH0107896
- Product name
- METHYL-5-AMINO-2-BROMOBENZOATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $629.53
- Updated
- 2021/12/16
5-AMINO-2-BROMO-BENZOIC ACID METHYL ESTER Chemical Properties,Usage,Production
Synthesis
6942-36-5
6942-37-6
General procedure for the synthesis of methyl 5-amino-2-bromobenzoate from methyl 2-bromo-5-nitrobenzoate: Methyl 2-bromo-5-nitrobenzoate (25.3 g, 97.3 mmol) was dissolved in anhydrous methanol (500 mL), followed by addition of stannous (II) chloride (93.3 g, 487 mmol). The reaction mixture was heated to reflux for 2 hours. Upon completion of the reaction, the mixture was cooled, ethyl acetate (500 mL) and water (100 mL) were added, and the reaction mixture was neutralized with 4N aqueous sodium hydroxide solution, followed by filtration through diatomaceous earth. The filtrate was concentrated under reduced pressure, ethyl acetate (200 mL) was added, and washed sequentially with saturated aqueous sodium bicarbonate (200 mL, 2 times), water (200 mL), and saturated brine (200 mL). The organic layer was dried with anhydrous magnesium sulfate and the solvent was removed under reduced pressure to afford the title compound methyl 5-amino-2-bromobenzoate (21.0 g) as a pale yellow oil in 94% yield.1H-NMR (400 MHz, DMSO-d6) δ 3.80 (s, 3H), 5.55 (s, 2H), 6.63 (dd, J = 8.8, 2.8 Hz, 1H), 6.94 (d, J = 2.8 Hz, 1H), 7.29 (d, J = 8.8 Hz, 1H).
References
[1] Patent: US2010/297073, 2010, A1. Location in patent: Page/Page column 20
[2] Journal of Organic Chemistry, 2017, vol. 82, # 15, p. 8296 - 8303
[3] Tetrahedron Letters, 2012, vol. 53, # 46, p. 6245 - 6249,5
[4] Patent: EP1995242, 2008, A1. Location in patent: Page/Page column 33
[5] Patent: EP2151436, 2010, A1. Location in patent: Page/Page column 17
5-AMINO-2-BROMO-BENZOIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-AMINO-2-BROMO-BENZOIC ACID METHYL ESTER manufacturers
- Product
- 5-AMINO-2-BROMO-BENZOIC ACID METHYL ESTER 6942-37-6
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-06
- Product
- 5-AMINO-2-BROMO-BENZOIC ACID METHYL ESTER 6942-37-6
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 10000MT
- Release date
- 2023-08-08