5-aMino-2-broMo-4-Methylbenzoic acid Methyl ester

Product Name: 5-aMino-2-broMo-4-Methylbenzoic acid Methyl ester
CAS No.: 474330-54-6
Chemical Name: 5-aMino-2-broMo-4-Methylbenzoic acid Methyl ester
Synonyms: Methyl 5-aMino-2-broMo-4-Methylbenzoate;5-aMino-2-broMo-4-Methylbenzoic acid Methyl ester;methyl 5-amino-2-bromo-4-methylbenzoate hydrochloride;Benzoic acid, 5-aMino-2-broMo-4-Methyl-, Methyl ester
CBNumber: CB12609963
Molecular Formula: C9H10BrNO2
Formula Weight: 244.09
MOL File: 474330-54-6.mol

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5-aMino-2-broMo-4-Methylbenzoic acid Methyl ester Property

Boiling point:: 328.4±37.0 °C(Predicted)
Density: 1.506±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 2.60±0.10(Predicted)
Appearance: Light brown to gray Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific

Product number: 7107AJ
Product name: Methyl5-amino-2-bromo-4-methylbenzoate
Packaging: 250mg
Price: $147
Updated: 2021/12/16

SynChem

Product number: SC-25750
Product name: 5-Amino-2-bromo-4-methylbenzoic acid methyl ester
Purity: 95%
Packaging: 5G
Price: $265
Updated: 2021/12/16

Chemenu

Product number: CM253109
Product name: Methyl5-amino-2-bromo-4-methylbenzoate
Purity: 95+%
Packaging: 5g
Price: $266
Updated: 2021/12/16

Ambeed

Product number: A308556
Product name: Methyl5-amino-2-bromo-4-methylbenzoate
Purity: 97%
Packaging: 5g
Price: $282
Updated: 2021/12/16

Crysdot

Product number: CD12069966
Product name: Methyl5-amino-2-bromo-4-methylbenzoate
Purity: 97%
Packaging: 5g
Price: $282
Updated: 2021/12/16

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5-aMino-2-broMo-4-Methylbenzoic acid Methyl ester Chemical Properties,Usage,Production

Synthesis

67-56-1

745048-63-9

474330-54-6

General procedure for the synthesis of methyl 5-amino-2-bromo-4-methylbenzoate from methanol and 5-amino-2-bromo-4-methylbenzoic acid: 5-amino-2-bromo-4-methylbenzoic acid (39.90 g, 0.17 mol) was suspended in methanol (500 mL). The suspension was cooled to 0 to 5 °C and thionyl chloride (40 mL, 0.54 mol) was added slowly and dropwise. The reaction mixture was heated to reflux for 6 hours. Upon completion of the reaction, the solution was concentrated under reduced pressure and the residue was diluted with ice water (500 g). The pH was adjusted to 7.5 with saturated aqueous sodium bicarbonate and subsequently extracted with ethyl acetate (3 x 200 mL). The organic phases were combined, washed with saturated saline (3 x 200 mL), dried over anhydrous magnesium sulfate, filtered and concentrated to dryness under reduced pressure to afford methyl 5-amino-2-bromo-4-methylbenzoate as a white solid (40.35 g, 95% yield).

References

[1] Patent: US2007/275907, 2007, A1. Location in patent: Page/Page column 19
[2] Patent: US2008/242596, 2008, A1. Location in patent: Page/Page column 15
[3] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 19, p. 5632 - 5635
[4] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 24, p. 6877 - 6881
[5] ChemMedChem, 2010, vol. 5, # 6, p. 827 - 831

5-aMino-2-broMo-4-Methylbenzoic acid Methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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5-aMino-2-broMo-4-Methylbenzoic acid Methyl ester Suppliers

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474330-54-6, 5-aMino-2-broMo-4-Methylbenzoic acid Methyl esterRelated Search:

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5-aMino-2-broMo-4-Methylbenzoic acid Methyl ester

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methyl 5-amino-2-bromo-4-methylbenzoate hydrochloride

474330-54-6