ChemicalBook > CAS DataBase List > 3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)-

3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)-

Product Name
3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)-
CAS No.
120964-45-6
Chemical Name
3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)-
Synonyms
DZNepHCl;NSC 617989 HCl;DZNEP; NSC 617989;DZNep hydrochloride;3-deazaneplanocin A HCl;NSC 617989 hydrochloride;3-deazaneplanocin A (DZNeP) HCl;3-Deazaneplanocin hydrochloride;DZNeP (3-deazaneplanocin A) HCl;3-Deazaneplanocin A (hydrochloride)
CBNumber
CB12623932
Molecular Formula
C12H15ClN4O3
Formula Weight
298.7255
MOL File
120964-45-6.mol
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3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)- Property

Melting point:
168-169℃
storage temp. 
-20°C
solubility 
H2O: ≥5mg/mL
form 
Tan solid
color 
white to beige
Water Solubility 
Soluble in water (10mM)
InChIKey
UNSKMHKAFPRFTI-FDKLLANESA-N
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0305
Product name
3-Deazaneplanocin A hydrochloride
Purity
≥97% (HPLC)
Packaging
1mg
Price
$473
Updated
2024/03/01
Sigma-Aldrich
Product number
252790
Product name
Histone Methyltransferase EZH2 Inhibitor, DZNep
Packaging
2mg
Price
$303
Updated
2024/03/01
Cayman Chemical
Product number
11102
Product name
3-Deazaneplanocin A (hydrochloride)
Purity
≥98%
Packaging
500μg
Price
$92
Updated
2024/03/01
Cayman Chemical
Product number
11102
Product name
3-Deazaneplanocin A (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$174
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0305
Product name
3-Deazaneplanocin A hydrochloride
Purity
≥97% (HPLC)
Packaging
5mg
Price
$1590
Updated
2024/03/01
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3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)- Chemical Properties,Usage,Production

Uses

3-Deazaneplanocin A is a a powerful inhibitor of S-adenosylhomocysteine hydrolase that has shown potent and selective in vitro and in vivo antiviral activities.

Uses

3-Deazaneplanocin A hydrochloride has been used to test its effect on ovarian tumor progression. It has also been used as a S-adenosyl homocysteine hydrolase (SAH) inhibitor in c33A2 cells.

General Description

3-Deazaneplanocin A hydrochloride is a carbocyclic analog of adenosine. It has antimetastatic?property. It is used to treat Ebola virus disease, gastric cancer, myeloma and lymphoma.

Biochem/physiol Actions

3-Deazaneplanocin A (DZNep) is an S-Adenosylhomocysteine Hydrolase inhibitor and histone methyltransferase EZH2 inhibitor. It switches on repressed tumor suppressor genes and induces apoptosis by inhibiting the expression of EZH2.

target

histone methyltransferase

storage

-20°C

3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)- Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)- Suppliers

Canada 1 China 77 India 1 United Kingdom 3 United States 13 Global 95
Carbosynth
Tel
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Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
Tocris Bioscience
Tel
--
Fax
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Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77
Sequoia Research Products Ltd.
Tel
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Fax
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Email
sales@seqchem.com
Country
United Kingdom
ProdList
3113
Advantage
69
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View Lastest Price from 3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)- manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
3-Deazaneplanocin A hydrochloride 120964-45-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
3-Deazaneplanocin A hydrochloride 120964-45-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08
Career Henan Chemical Co
Product
3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)- 120964-45-6
Price
US $1.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
200kg
Release date
2019-12-23

120964-45-6, 3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)-Related Search:

Tazemetostat (EPZ-6438) Saracatinib GSK 343 PD 0325901 ALK5 inhibitor II CHIR-99021

  • 3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)-
  • 3-Deazaneplanocin A (hydrochloride)
  • 3-Deazaneplanocin hydrochloride
  • DZNep hydrochloride
  • DZNEP; NSC 617989
  • NSC 617989 hydrochloride
  • (-)-1-[(1R,4R,5S)-3-(HydroxyMethyl)-4,5-dihydroxy-2-cyclopenten-1-yl]4-aMinoiMidazo[4,5-c]pyridine hydrochloride DZNep hydrochloride
  • (1S,2R,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1,2-diol hydrochloride (1:1)
  • 1H-Imidazo[4,5-c]pyridine, 3-cyclopentene-1,2-diol deriv.
  • 3-deazaneplanocin A HCl
  • 3-deazaneplanocin A (DZNeP) HCl
  • NSC 617989 HCl
  • (-)-1-[(1R,4R,5S)-3-(Hydroxymethyl)-4,5-dihydroxy-2-cyclopenten-1-yl]4-aminoimidazo[4,5-c]pyridine hydrochloride
  • Histone Methyltransferase EZH2 Inhibitor, DZNep
  • Histone Methyltransferase EZH2 Inhibitor, DZNep - CAS 120964-45-6 - Calbiochem
  • (1S,2R,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1,2-diol hydrochloride
  • 3-Deazaneplanocin A (DZNep) hydrochloride
  • DZNEP HYDROCHLORIDE;NSC 617989 HYDROCHLORIDE;3-DEAZANEPLANOCIN HYDROCHLORIDE
  • 3-deazaneplanocin A HCl (DZNep HCl)
  • DZNepHCl
  • 3-Deazaneplanocin A hydrochloride (DZNep hydrochloride
  • 3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)- USP/EP/BP
  • (1S,2R,5R)-5-(4-aminoimidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol
  • DZNeP (3-deazaneplanocin A) HCl
  • 120964-45-6
  • C12H14N4O3HCl
  • C12H14N4O3ClH
  • Inhibitors
  • 1