ChemicalBook > CAS DataBase List > (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone

Product Name
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
CAS No.
915095-86-2
Chemical Name
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
Synonyms
Englenet Impurity 16;Empagliflozin Impurity 48;2-chloro-4-fluoro-5-Iodobenzophenon;2-Chloro-4'-fluoro-5-iodobenzophenone;2-Chloro-4'-fluoro-5-iodobenzophenone;Empagliflozin Impurity 48 /Englenet Impurity 16;(2-Chloro-5-iodobenyl)(4-fluorophenyl)methanone;(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanon;(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone;Methanone, (2-chloro-5-iodophenyl)(4-fluorophenyl)-
CBNumber
CB12651407
Molecular Formula
C13H7ClFIO
Formula Weight
360.55
MOL File
915095-86-2.mol
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(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Property

Melting point:
64-70℃
Boiling point:
415℃
Density 
1.752
Flash point:
205℃
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
Chloroform (Slightly), Ethyl Acetate
form 
Solid
color 
Off-White
InChI
InChI=1S/C13H7ClFIO/c14-12-6-5-10(16)7-11(12)13(17)8-1-3-9(15)4-2-8/h1-7H
InChIKey
KNYGUQLVFSPVRI-UHFFFAOYSA-N
SMILES
C(C1=CC(I)=CC=C1Cl)(C1=CC=C(F)C=C1)=O
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Safety

Safety Statements 
24/25
HS Code 
29142990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C368575
Product name
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
Packaging
2.5g
Price
$595
Updated
2021/12/16
AK Scientific
Product number
9597AF
Product name
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
Packaging
100g
Price
$605
Updated
2021/12/16
Apolloscientific
Product number
PC540099
Product name
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
Purity
98%
Packaging
100g
Price
$634
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
91537
Product name
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
Packaging
1g
Price
$725
Updated
2021/12/16
Apolloscientific
Product number
PC540099
Product name
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
Purity
98%
Packaging
25g
Price
$224
Updated
2021/12/16
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(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Chemical Properties,Usage,Production

Uses

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone is a reagent in the synthesis of Empagliflozin (E521510); an inhibitor of SGLT-2.

Synthesis

5-Iodo-2-chlorobenzoic acid (20.0 g, 0.071 mol) was added to a solution of 2.0 M oxalyl chloride in dichloromethane (39 ml, 0.078 mol), stirred for suspension, and then 8 drops of DMF solution was added dropwise. The solution was clarified after the reaction was carried out for 3 hours. The solvent was spin-dried on a rotary evaporator, and then 15 ml of methylene chloride was added. After spin-drying, add 30 ml of dichloromethane, stir, cool to 0-5 ° C, add fluorobenzene (7. lg, 0.074 mol), add anhydrous aluminum trichloride (9.9 g, 0.074 mol) in batches, control The temperature is not more than 5 °C, after the completion of the addition, stirring is continued at 4 ° C for 1 h, the reaction is quenched on the ice-water mixture, the organic phase is separated, and the aqueous phase is extracted with dichloromethane. The phase was washed twice with 1 mol/L hydrochloric acid, once with water, and twice with 1 mol/L NaOH solution. The mixture was washed twice with saturated sodium chloride and dried over anhydrous sodium sulfate. Drain filtration, spin dry solvent to obtain oil after column chromatography, 20. 1g (78.6percent) of a white solid (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone was obtained.

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Preparation Products And Raw materials

Raw materials

Preparation Products

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(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Suppliers

China 211 India 9 United Kingdom 1 United States 8 Global 229
Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58
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View Lastest Price from (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone manufacturers

Suzhou Nordica Biopharma CO.,LTD
Product
2-Chloro-4'-fluoro-5-iodobenzophenone 915095-86-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
0.99
Supply Ability
5 tons
Release date
2024-11-14
Hebei Yanxi Chemical Co., Ltd.
Product
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone 915095-86-2
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-08
Shanghai Joiny Pharmaceutical Co.,LTD
Product
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone 915095-86-2
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
500k
Release date
2023-09-08

915095-86-2, (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanoneRelated Search:

Acetoxy Empagliflozin Empagliflozin Impurity 23 Empagliflozin (R)-Isomer ((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)Methyl acetate N/A Butanoic acid, 4-chloro-3-hydroxy-, (3S)- (4R,5R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl) phenyl)-5-((R)-1,2-dihydroxyethyl)tetrahydrofuran-3,4-diol (3R,4S,5S,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxyMethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol 4-CHLORO-2-FLUOROIODOBENZENE DIPHENYLENEIODONIUM CHLORIDE (S)-(5-broMo-2-chlorophenyl)(4-(tetrahydrofuran-3-yloxy)phenyl)Methanone (3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]- (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone (2S,3R,4S,5S,6R)-2-(3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxyMethyl)-2-Methoxy-2H-pyran-3,4,5-triol 2,3,4,6-Tetra-O-benzyl-a-D-glucopyranosylbromide (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran (R)-3-(4-(5-broMo-2-chlorobenzyl)phenoxy)tetrahydrofuran

  • (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
  • Methanone, (2-chloro-5-iodophenyl)(4-fluorophenyl)-
  • (2-Chloro-5-iodobenyl)(4-fluorophenyl)methanone
  • Empagliflozin Impurity 48
  • Englenet Impurity 16
  • 2-chloro-4-fluoro-5-Iodobenzophenon
  • (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanon
  • 2-Chloro-4'-fluoro-5-iodobenzophenone
  • (2-Chloro-5-iodine phenyl) 4-fluorophenyl) methylone
  • Empagliflozin Impurity 48 /Englenet Impurity 16
  • 2-Chloro-4'-fluoro-5-iodobenzophenone
  • 915095-86-2
  • 945065-86-2
  • C13H7ClFIO